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Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

《医学前沿（英文）》 2021年 第15卷 第3期   页码 347-371 doi: 10.1007/s11684-020-0821-6

摘要： B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations with high heterogeneity. Precise subtypes with distinct genomic and/or gene expression patterns have been recently revealed using high-throughput sequencing technology. Most of these profiles are associated with recurrent non-overlapping rearrangements or hotspot point mutations that are analogous to the established subtypes, such as rearrangements, rearrangements, rearrangements, rearrangements, / and/or rearrangements, like gene expression, PAX5alt (diverse alterations, including rearrangements, intragenic amplifications, or mutations), and hotspot mutations PAX5 (p.Pro80Arg) with biallelic alterations, IKZF1 (p.Asn159Tyr), and ZEB2 (p.His1038Arg). These molecular subtypes could be classified by gene expression patterns with RNA-seq technology. Refined molecular classification greatly improved the treatment strategy. Multiagent therapy regimens, including target inhibitors (e.g., imatinib), immunomodulators, monoclonal antibodies, and chimeric antigen receptor T-cell (CAR-T) therapy, are transforming the clinical practice from chemotherapy drugs to personalized medicine in the field of risk-directed disease management. We provide an update on our knowledge of emerging molecular subtypes and therapeutic targets in BCP-ALL.

关键词： BCP-ALL     subtypes     translocation     aneuploidy     sequence mutations    

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Engineering Management to Serve All Human Beings

Yong-fu Sun

《工程管理前沿（英文）》 2014年 第1卷 第3期   页码 231-231 doi: 10.15302/J-FEM-2014032

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Enhanced charge extraction for all-inorganic perovskite solar cells by graphene oxide quantum dots modified

《化学科学与工程前沿（英文）》 2023年 第17卷 第5期   页码 516-524 doi: 10.1007/s11705-022-2238-z

摘要： All-inorganic cesium lead bromide (CsPbBr3) perovskite solar cells have been attracting growing interest due to superior performance stability and low cost. However, low light absorbance and large charge recombination at TiO2/CsPbBr3 interface or within CsPbBr3 film still prevent further performance improvement. Herein, we report devices with high power conversion efficiency (9.16%) by introducing graphene oxide quantum dots (GOQDs) between TiO2 and perovskite layers. The recombination of interfacial radiation can be effectively restrained due to enhanced charge transfer capability. GOQDs with C-rich active sites can involve in crystallization and fill within the CsPbBr3 perovskite film as functional semiconductor additives. This work provides a promising strategy to optimize the crystallization process and boost charge extraction at the surface/interface optoelectronic properties of perovskites for high efficient and low-cost solar cells.

关键词： all inorganic     perovskite solar cells     graphene oxide quantum dots     high performance     stability    

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Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID

《医学前沿（英文）》 2022年 第16卷 第1期   页码 102-110 doi: 10.1007/s11684-021-0850-9

摘要： Consecutively hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) in Wuhan, China were retrospectively enrolled from January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitor (RAS-I) and the outcome of this disease. Associations between the use of RAS-I (angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB)), ACEI, and ARB and in-hospital mortality were analyzed using multivariate Cox proportional hazards regression models in overall and subgroup of hypertension status. A total of 2771 patients with COVID-19 were included, with moderate and severe cases accounting for 45.0% and 36.5%, respectively. A total of 195 (7.0%) patients died. RAS-I (hazard ratio (HR)=0.499, 95% confidence interval (CI) 0.325–0.767) and ARB (HR=0.410, 95% CI 0.240–0.700) use was associated with a reduced risk of all-cause mortality among patients with COVID-19. For patients with hypertension, RAS-I and ARB applications were also associated with a reduced risk of mortality with HR of 0.352 (95% CI 0.162–0.764) and 0.279 (95% CI 0.115–0.677), respectively. RAS-I exhibited protective effects on the survival outcome of COVID-19. ARB use was associated with a reduced risk of all-cause mortality among patients with COVID-19.

关键词： COVID-19     RAS inhibitor     hypertension     all-cause mortality    

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“ALL FREE” — a novel design concept of applying partial oxidation process to vehicle

Ling LIN, Wenshuang LIN, Qingbiao LI, Yao ZHOU,

《化学科学与工程前沿（英文）》 2010年 第4卷 第2期   页码 207-212 doi: 10.1007/s11705-009-0240-3

摘要： With the rapid expansion of the global motor vehicle population, the transportation sector has taken up a growing proportion among all the carbon dioxide emission-related sectors. To contribute to solutions of the carbon dioxide-oriented problem in transportation, this paper proposes the “ALL FREE” concept that applies partial oxidation process instead of the conventional complete oxidation to vehicle engines. In such an engine, the fuels are partially oxidized into corresponding chemical products, which, as a result, enable the process to be theoretically free of CO, while the heat output of the partial oxidation could drive the vehicle. On the other hand, the resulting products are of great value, which could decrease or even counteract the cost of fuels in transportation. In this paper, the thermodynamic and kinetic data (e.g., the heat output and heat release rate) of five selected partial oxidation reactions were calculated at length to demonstrate and exemplify the theoretical feasibility of the “ALL FREE” concept. It turned out that the partial oxidation of -butane to maleic anhydride has the most potential to meet the basic requirements of this concept. To sum up, this design concept is of significant application potential for the reduction of CO emissions in the transportation industry, although there remain many technical challenges.

关键词： oxidation process     CO     complete oxidation     ALL FREE     -butane    

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Application of BCP-2007 and UBC-97 in seismic vulnerability assessment of gravity designed RC buildings

Muhammad Usman ALI, Shaukat Ali KHAN, Muhammad Yousaf ANWAR

《结构与土木工程前沿（英文）》 2017年 第11卷 第4期   页码 396-405 doi: 10.1007/s11709-017-0436-4

摘要： Recent earthquakes in Pakistan (Kashmir 2005, Balochistan 2008, and Balochistan 2013) revealed the vulnerability of existing building stock and the deficiencies in the then prevalent Pakistan Seismic Code (PSC-86 (1986)). This study investigates, through an analytical framework, the seismic vulnerability of these and other such buildings, in accordance with the newly developed Building Code of Pakistan – Seismic Provisions 2007 (BCP-SP 07). Detailed failure mode is presented for buildings designed as per the new code. Collapse of structures is predicted for only 8% increase in PGA after moderate damage. A previously developed method, based on Eurocode-8 (2004), is used as baseline. A deficient reinforced concrete frame, typical to local building practices, is analyzed and assessed for vulnerability using the BCP- SP 07 (2007) framework. A comparison is drawn for the same building, based on Eurocode-8 (2004). Derived vulnerability curves show that the previous framework overestimated the damage and hence the vulnerability. Comparison of vulnerability parameters with previous studies show slight difference in performance of buildings.

关键词： Building Code of Pakistan     earthquake engineering     seismic effects     vulnerability assessment of buildings     vulnerability framework    

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Primary health care for all by 2020: The systematic reform of the medical and health system in China

《医学前沿（英文）》 2010年 第4卷 第1期   页码 3-7 doi: 10.1007/s11684-010-0024-7

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用于超快电子器件的全通型波导 Article

Desong Wang, Ke Wu

《工程（英文）》 2023年 第30卷 第11期   页码 49-54 doi: 10.1016/j.eng.2023.04.005

摘要：

Ultrashort pulse transmission has been recognized as a primary problem that fundamentally hinders the development of ultrafast electronics beyond the current nanosecond timescale. This requires a transmission line or waveguide that exhibits an all-pass frequency behavior for the transmitted ultrashort pulse signals. However, this type of waveguiding structure has not yet been practically developed; groundbreaking innovations and advances in signal transmission technology are urgently required to address this scenario. Herein, we present a synthesized all-pass waveguide that demonstrates record guided-wave controlling capabilities, including eigenmode reshaping, polarization rotation, loss reduction, and dispersion improvement. We experimentally developed two waveguides for use in ultrabroad frequency ranges (direct current (DC)-to-millimeter-wave and DC-to-terahertz). Our results suggest that the waveguides can efficiently transmit picosecond electrical pulses while maintaining signal integrity. This waveguide technology is an important breakthrough in the evolution of ultrafast electronics, providing a path towards frequency-engineered ultrashort pulses for low-loss and low-dispersion transmissions.

关键词： All-pass waveguide     Ultrashort pulse     Picosecond transmission     Ultrafast electronics     Terahertz technology     Mode-selective transmission line    

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统一集论与人工智能

张江,林华,贺仲雄

《中国工程科学》 2002年 第4卷 第3期   页码 40-47

摘要：

通过综合经典集合、模糊集合、可拓集合、Vague集合、粗糙集合、集对分析、FHW（模糊灰色物元空间）、FEEC（模糊可拓经济控制）等多种理论，提出了统一集概念，并详细讨论统一集的各种运算以及相关性质。从分析集合理论和人类思维形式之间的关系人手，把统一集理论初步应用到模式识别、聚类分析、逻辑推理、机器学习、智能决策等多种人工智能领域，指出了集合论及其运算系统与逻辑推理系统的等价关系。统一集能对现有的理论进行总结、统一，还为开辟崭新的集合论、逻辑推理方法提供很好的理论基础。

关键词： 统一集     人工智能     集合     运算     逻辑推理    

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Thanks to all medical workers fighting against COVID-19

Xiao-ping Chen

《医学前沿（英文）》 2020年 第14卷 第2期   页码 249-250 doi: 10.1007/s11684-020-0789-2

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Yellow fever and Hajj: with all eyes on Zika, a familiar flavivirus remains a threat

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 527-530 doi: 10.1007/s11684-016-0487-2

摘要：

Hajj is among the world’s largest mass gatherings, drawing between 2 and 3.5 million Muslims from 183 nations annually to perform pilgrimage in Mecca, Saudi Arabia. Infectious disease outbreaks can be imported both into the Hajj population and exported internationally by returning pilgrims. The domestic Saudi population can also be at risk of outbreaks traveling amid this mass migration. With yellow fever reported for the first time in China following the infection of expatriate Chinese workers in Angola and a full blown outbreak underway in wider West Africa, the prospect of yellow fever outbreaks in Asia threatens to impact Saudi Arabia, both during and beyond the Hajj season. With global focus trained on Zika, the rising threat of yellow fever cannot be overlooked. Strategies to mitigate risk to Saudi Arabia and the global population are thereby suggested.

关键词： yellow fever     mass gathering     Saudi Arabia     Hajj     Zika virus    

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全气候新能源汽车关键技术及展望

王文伟,孙逢春

《中国工程科学》 2019年 第21卷 第3期   页码 47-55 doi: 10.15302/J-SSCAE-2019.03.020

摘要：

全气候新能源汽车是指能够适应包括高温、高湿和极寒等各种气候环境的新能源汽车，相对于目前高温高湿环境下较为成熟的隔热散热与防护技术，新能源汽车在超过–30 ℃的极寒环境下存在无法启动、续驶里程锐减、充电困难等问题，是国际社会公认的制约新能源汽车全气候应用的难题。本文分析研究了动力电池自加热技术、高效冷暖一体化热泵空调技术、新型整车隔热保温技术等全气候新能源汽车技术体系，并进行了整车集成开发及极寒环境试验，最后分析了全气候新能源汽车的技术发展趋势。本文所述的研究成果将通过在2022 年北京冬季奥林匹克运动会上率先进行示范应用，从而推动我国乃至国际新能源汽车的全气候应用。

关键词： 全气候新能源汽车     电池自加热     热泵空调     隔热保温    

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children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL

《医学前沿（英文）》 2023年 第17卷 第3期   页码 518-526 doi: 10.1007/s11684-022-0958-6

摘要： Venous thromboembolism (VTE) is a complication in children with acute lymphoblastic leukemia (ALL). The Chinese Children’s Cancer Group-ALL-2015 protocol was carried out in China, and epidemiology, clinical characteristics, and risk factors associated with VTE were analyzed. We collected data on VTE in a multi-institutional clinical study of 7640 patients with ALL diagnosed in 20 hospitals from January 2015 to December 2019. First, VTE occurred in 159 (2.08%) patients, including 90 (56.6%) during induction therapy and 108 (67.92%) in the upper extremities. T-ALL had a 1.74-fold increased risk of VTE (95% CI 1.08–2.8, P = 0.022). Septicemia, as an adverse event of ALL treatment, can significantly promote the occurrence of VTE (P < 0.001). Catheter-related thrombosis (CRT) accounted for 75.47% (n = 120); and, symptomatic VTE, 58.49% (n = 93), which was more common in patients aged 12–18 years (P = 0.023), non-CRT patients (P < 0.001), or patients with cerebral thrombosis (P < 0.001). Of the patients with VTE treated with anticoagulation therapy (n = 147), 4.08% (n = 6) had bleeding. The VTE recurrence rate was 5.03% (n = 8). Patients with VTE treated by non-ultrasound-guided venous cannulation (P = 0.02), with residual thrombus (P = 0.006), or with short anticoagulation period (P = 0.026) had high recurrence rates. Thus, preventing repeated venous puncture and appropriately prolonged anticoagulation time can reduce the risk of VTE recurrence.

关键词： acute lymphoblastic leukemia     child     venous thromboembolism     epidemiology     clinical characteristic     risk factor    

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盾构进出洞全方位风险控制冻结加固技术

嵇彭

《中国工程科学》 2012年 第14卷 第2期   页码 90-95

摘要：

在含水复杂的地质条件下采用水平冻结法进行盾构进出洞施工，可以通过延长（加深）水平冻结外圈冻结深度，使冻结加固体全方位包裹并超过盾构机本体，利用外圈冻结孔的维护冻结，将盾构推进过程中形成的微小流水通道中的泥土冻结成为冻土，封闭流水通道，较为有效地防止了流水、涌砂现象的发生。利用长距离水平钻孔防喷接驳器，简单方便地解决了在已施工完毕的端头井内长距离钻孔的难题。工程实践证明，全方位风险控制冻结加固技术在复杂地质条件下盾构进出洞施工中，简单易行，安全可靠，值得推广应用。

关键词： 复杂地质条件     盾构进出洞     全方位     风险控制     冻结加固    

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Single incision laparoscopic cholecystectomy using the one-incision three-trocar technique with all straight

Hongyi Cui

《医学前沿（英文）》 2011年 第5卷 第3期   页码 283-287 doi: 10.1007/s11684-011-0151-9

摘要： Single incision laparoscopic surgery (SILS) is a novel minimally invasive surgical technique that is gaining popularity around the world. One of the most commonly performed procedures is single incision laparoscopic cholecystectomy (SILC). Most reported techniques utilize special purpose-made access port and articulating instruments, rendering the procedure costly and difficult to learn. This article provides a stepwise description of SILC technique using all straight instruments without the need for a special port. It aims to shorten the learning curve for surgeons wishing to adopt a safe and cost-effective SILC technique to their practice.

关键词： laparoscopic cholecystectomy     single incision laparoscopic surgery    

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标题 作者 时间 类型 操作

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

期刊论文

Engineering Management to Serve All Human Beings

Yong-fu Sun

期刊论文

Enhanced charge extraction for all-inorganic perovskite solar cells by graphene oxide quantum dots modified

期刊论文

Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID

期刊论文

“ALL FREE” — a novel design concept of applying partial oxidation process to vehicle

Ling LIN, Wenshuang LIN, Qingbiao LI, Yao ZHOU,

期刊论文

Application of BCP-2007 and UBC-97 in seismic vulnerability assessment of gravity designed RC buildings

Muhammad Usman ALI, Shaukat Ali KHAN, Muhammad Yousaf ANWAR

期刊论文

Primary health care for all by 2020: The systematic reform of the medical and health system in China

期刊论文

用于超快电子器件的全通型波导

Desong Wang, Ke Wu

期刊论文

统一集论与人工智能

张江,林华,贺仲雄

期刊论文

Thanks to all medical workers fighting against COVID-19

Xiao-ping Chen

期刊论文

Yellow fever and Hajj: with all eyes on Zika, a familiar flavivirus remains a threat

null

期刊论文

全气候新能源汽车关键技术及展望

王文伟,孙逢春

期刊论文

children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL

期刊论文

盾构进出洞全方位风险控制冻结加固技术

嵇彭

期刊论文

Single incision laparoscopic cholecystectomy using the one-incision three-trocar technique with all straight

Hongyi Cui

期刊论文