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Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 420-429 doi: 10.1007/s11684-016-0478-3
Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemogenesis of acute promyelocytic leukemia (APL). We found that CDKN2C was markedly downregulated in APL blasts compared with normal promyelocytes. Chromatin immunoprecipitation combined with quantitative polymerase chain reaction demonstrated that PML/RARα directly bound to the CDKN2C promoter in the APL patient-derived cell line NB4. Luciferase assays indicated that PML/RARα inhibited the CDKN2C promoter activity in a dose-dependent manner. Furthermore, all-trans retinoic acid treatment induced CDKN2C expression by releasing the PML/RARα binding on chromatin in NB4 cells. Functional studies showed that ectopic expression of CDKN2C induced a cell cycle arrest at the G0/G1 phase and a partial differentiation in NB4 cells. Finally, the transcriptional regulation of CDKN2C was validated in primary APL patient samples. Collectively, this study highlights the importance of CDKN2C inactivation in the abnormal cell cycle progression and differentiation block of APL cells and may provide new insights into the study of pathogenesis and targeted therapy of APL.
关键词: CDKN2C acute promyelocytic leukemia cell cycle arrest differentiation
Jian LI, Likun GAO, Wentao GAN
《农业科学与工程前沿(英文)》 2017年 第4卷 第4期 页码 459-464 doi: 10.15302/J-FASE-2017178
关键词: bioinspired butterfly wings C/TiO2 photocatalyst visible light
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1986-2000 doi: 10.1007/s11705-023-2337-5
关键词: sp3/sp2-hybridized C–N bond noble metal nanoparticle catalytic active site turnover frequency DFT
Sarah C.P. Williams
《工程(英文)》 2023年 第22卷 第3期 页码 7-9 doi: 10.1016/j.eng.2023.01.002
《化学科学与工程前沿(英文)》 2023年 第17卷 第4期 页码 373-386 doi: 10.1007/s11705-022-2223-6
关键词: carbon cloth NiCo2O4 nanowires core−shell structure quinone-rich electric double layer capacitor
New insight into effect of potential on degradation of Fe-N-C catalyst for ORR
Yanyan GAO, Manman QI, Liang HE, Haiping CHEN, Wenzhe LUO, Ming HOU, Zhigang SHAO
《能源前沿(英文)》 2021年 第15卷 第2期 页码 421-430 doi: 10.1007/s11708-021-0727-2
关键词: proton exchange membrane fuel cells (PEMFCs) oxygen reduction reaction (ORR) Fe-N-C catalyst potential H2O2 degradation
富含sn-2 DHA脂质对大脑的益处及其酶法合成综述 Review
金俊, 金青哲, 王兴国, Casimir C. Akoh
《工程(英文)》 2020年 第6卷 第4期 页码 424-431 doi: 10.1016/j.eng.2020.02.009
Durability of plasma-sprayed Cr3C2-NiCr coatings under rolling contact conditions
Xiancheng ZHANG, Fuzhen XUAN, Shantung TU, Binshi XU, Yixiong WU
《机械工程前沿(英文)》 2011年 第6卷 第1期 页码 118-135 doi: 10.1007/s11465-011-0127-0
The aim of this paper was to address the rolling contact fatigue (RCF) failure mechanisms of plasma-sprayed Cr3C2-NiCr coatings under different tribological conditions of contact stress. Weibull distribution plots of fatigue lives of the coated specimens at different contact stresses were obtained. The failure modes of coatings were identified on the basis of wore surface observations of the failed coatings. Results showed that the RCF failure modes can be classified into four main categories, i.e., surface abrasion, spalling, cohesive delamination, and interfacial delamination. The probabilities of the surface abrasion and spalling type failures were relatively high at low contact stress. When the coatings were subjected to abrasion and spalling type failures, the failure of the coating was depended on the microstrcture of the coating. The stress concentration near the micro-defects in the coating may be the may reason for the formation of spall. The coatings were prone to fail in delamination under higher contact stresses. However, the delamination of coating may be related to distribution of shear stress amplitude within coating. The location of maximum shear stress amplitude can be used as a key parameter to predict the initiation of subsurface cracks within coating in rolling contact.
关键词: rolling contact fatigue coating Weibull distribution failure mode mechanism
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
《医学前沿(英文)》 2020年 第14卷 第1期 页码 81-90 doi: 10.1007/s11684-019-0692-x
关键词: soluble C-type lectin-like receptor-2 coronary artery disease risk factor
A state-of-the-art review of solar passive building system for heating or cooling purpose
Arun Kumar NANDA,C K PANIGRAHI
《能源前沿(英文)》 2016年 第10卷 第3期 页码 347-354 doi: 10.1007/s11708-016-0403-0
关键词: HVAC heating cooling solar heating carbon dioxide (CO2) emissions
In situ DRIFTS study of photocatalytic CO 2 reduction under UV irradiation
Jeffrey C. S. WU, Chao-Wei HUANG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 120-126 doi: 10.1007/s11705-009-0232-3
关键词: irradiation oxygen-vacancy Photocatalytic reduction Carbonate butoxide
An electrochemical process that uses an Fe
Chaojie Jiang, Lifen Liu, John C. Crittenden
《环境科学与工程前沿(英文)》 2016年 第10卷 第4期 doi: 10.1007/s11783-016-0860-z
关键词: Bio-anode Photocatalytic cathode Fe0/TiO2 ESR Dye and antibiotics Advanced oxidation
未知辐射源信号特征辅助的广义标签多伯努利滤波器 Research Article
国强1,滕龙1,2,吴新良2,宋文明2,黄大羽2
《信息与电子工程前沿(英文)》 2022年 第23卷 第12期 页码 1871-1880 doi: 10.1631/FITEE.2200286
Xiying Hao, Francis J. Larney
《环境科学与工程前沿(英文)》 2017年 第11卷 第3期 doi: 10.1007/s11783-017-0955-1
关键词: Livestock manure greenhouse gas flux straw bale compost bin N2O CH4 CO2
适于低成本嵌入式硬件的2R-1C模型非迭代参数估计 Article
Mitar SIMIĆ, Zdenka BABIĆ, Vladimir RISOJEVIĆ, Goran M. STOJANOVIĆ
《信息与电子工程前沿(英文)》 2020年 第21卷 第3期 页码 476-490 doi: 10.1631/FITEE.1900112
标题 作者 时间 类型 操作
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
null
期刊论文
Effect of noble metal nanoparticle size on C–N bond cleavage performance in hydrodenitrogenation: a study
期刊论文
NiCo2O4@quinone-rich N–C core–shell nanowires as composite electrode for electric double layer capacitor
期刊论文
New insight into effect of potential on degradation of Fe-N-C catalyst for ORR
Yanyan GAO, Manman QI, Liang HE, Haiping CHEN, Wenzhe LUO, Ming HOU, Zhigang SHAO
期刊论文
Durability of plasma-sprayed Cr3C2-NiCr coatings under rolling contact conditions
Xiancheng ZHANG, Fuzhen XUAN, Shantung TU, Binshi XU, Yixiong WU
期刊论文
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
期刊论文
A state-of-the-art review of solar passive building system for heating or cooling purpose
Arun Kumar NANDA,C K PANIGRAHI
期刊论文
In situ DRIFTS study of photocatalytic CO 2 reduction under UV irradiation
Jeffrey C. S. WU, Chao-Wei HUANG,
期刊论文
Greenhouse gas emissions during co-composting of cattle feedlot manure with construction and demolition (C&
Xiying Hao, Francis J. Larney
期刊论文