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《医学前沿(英文)》 2018年 第12卷 第2期 页码 182-188 doi: 10.1007/s11684-017-0529-4
With the abuse of antimicrobial agents in developing countries, increasing number of carbapenem-resistant Enterobacteriaceae (CRE) attracted considerable public concern. A retrospective study was conducted based on 242 CRE strains from a tertiary hospital in Hangzhou, China to investigate prevalence and drug resistance characteristics of CRE in southeast China. Bacterial species were identified. Antimicrobial susceptibility was examined by broth microdilution method or epsilometer test. Resistant β-lactamase genes were identified by polymerase chain reaction and sequencing. Genotypes were investigated by phylogenetic analysis. and were the most prevalent types of species, with occurrence in 71.9% and 21.9% of the strains, respectively. All strains exhibited high resistance (>70%) against β-lactam antibiotics, ciprofloxacin, trimethoprim–sulfamethoxazole, and nitrofurantoin but exhibited low resistance against tigecycline (0.8%) and minocycline (8.3%). A total of 123 strains harbored more than two kinds of β-lactamase genes. , , , and were the predominant genotypes, with detection rates of 60.3%, 61.6%, 43.4%, and 16.5%, respectively, and were highly identical with reference sequences in different countries, indicating potential horizontal dissemination. IMP-4 was the most frequent class B metallo-lactamases in this study. In conclusion, continuous surveillance and effective prevention should be emphasized to reduce spread of CRE.
关键词: Enterobacteriaceae carbapenem β-lactamase genes phylogenetic analysis
Characterization of NDM-1-producing carbapenemase in
Rongmin ZHANG,Yang WANG,Zhihai LIU,Jiyun LI,Wenjuan YIN,Lei LEI,Congming WU,Jianzhong SHEN
《农业科学与工程前沿(英文)》 2015年 第2卷 第3期 页码 223-229 doi: 10.15302/J-FASE-2015065
关键词: carbapenemase NDM-1 ISAba125 Enterobacteriaceae food safety
标题 作者 时间 类型 操作
Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou
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