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Assessment of toxicity of two nitroaromatic compounds in the freshwater fish

Hongyan SHEN, Jixi GAO, Jinsheng WANG

《环境科学与工程前沿（英文）》 2012年第6卷第4期页码 518-523 doi: 10.1007/s11783-012-0427-6

摘要： This study was conducted to evaluate the toxicological response of -nitrotoluene and -nitroaniline to the key fish species, . A freshwater fish bioassay based on the 96 h was used to estimate the single and joint toxicity of the two chemicals. The toxicity of -nitrotoluene was greater than that of -nitroaniline based on 96 h values of 40.74 mg·L and 48.99 mg·L , respectively. Both compounds had moderate toxicity toward , and this toxicity increased with the exposure duration and concentration. Binary mixtures of the compounds were more toxic than the individual compounds at 96 h, and they acted upon partial addition. When the exposure time was longer, the toxicity increased for mixtures of compounds with the same concentration or toxicity. The results of this study suggest that exposure to a combination of these chemicals would result in a higher environmental risk in aquatic systems than exposure to either compound alone. Further research is needed to investigate the combined effects and sublethal toxicity of -nitrotoluene and -nitroaniline, since they are both still used in China.

关键词： joint toxicity Cyprinus carpio LC₅₀ p-nitrotoluene p-nitroaniline toxic unit

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P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

《医学前沿（英文）》 2007年第1卷第4期页码 429-432 doi: 10.1007/s11684-007-0084-5

摘要： The aim of this research was to investigate the variations of P50 auditory sensory gating (P50) in normal healthy adults and the first onset schizophrenics. By using the American Nicolet Bravo electromyography/evoked potential (EMG/EP) system, P50 was measured with conditioning-testing paradigm (paired-click stimuli S1 and S2 were used) in 58 first onset schizophrenics and 108 healthy adults, and the Positive and Negative Syndrome Scale (PANSS) was applied. The following three conclusions have been reached. (1) In normal control (NC) group, measured from central, anterior and posterior zone (Cz, Fz and Pz respectively), there were no statistical differences (>0.05) between S1 and S2 evoked P50 peak latencies (S1-P50 and S2-P50); the amplitudes of S2-P50 [(2.2±1.4), (2.3±1.5) and (2.1±1.4) μV respectively] reduced significantly as compared with S1-P50 [(5.6±3.3), (5.6±3.9) and (4.9±2.8) μV respectively] (<0.01); the S2/S1 ration, S1-S2 difference, and 100 (1-S2/S1) had no statistical differences (>0.05). (2) Compared with NC, the schizophrenic group significantly showed lower S1-P50 amplitudes (<0.01, except at Pz in which = 2.030, = 0.042), higher S2-P50 amplitudes, higher S2/S1 ratio, lower S1-S2 difference, and more decreased 100 (1-S2/S1) (<0.01) at Cz, Fz and Pz. (3) No significant correlations were found among S2/S1 ratio, S1-S2, 100 (1-S2/S1) of sensory gating and PANSS (>0.05) in schizophrenic group. The first onset schizophrenics had sensory gating deficits, which could be quantified by P50.

关键词： anterior Positive S2-P50 schizophrenic EMG/EP

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GC/LC-Q-TOFMS 两种技术联用同时筛查水果蔬菜中733 种农药残留 Article

庞国芳, 常巧英, 白若镔, 范春林, 张紫娟, 闫宏远, 吴兴强

《工程（英文）》 2020年第6卷第4期页码 432-441 doi: 10.1016/j.eng.2019.08.008

摘要：

本文通过创建LC-Q-TOFMS（525种农药）和GC-Q-TOFMS（485种农药和209种PCBs）两大精确质谱数数据库，开发了一次样品制备、两种高分辨质谱联用同时检测733种农药化学污染物残留的检测方法种代表性水果蔬菜对联用技术的筛查农药范围、灵敏度、回收率和重现性等方法效能评价，显示出这项联用技术有三方面优势：①两种技术联用与单种技术相比，其发现能力分别提高了51.1%（GC-Q-TOFMS，485种）和39.6%（LC-Q-TOFMS

关键词：农药残留 GC-Q-TOFMS LC-Q-TOFMS 精确质量数据库谱图库水果蔬菜

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Achievements in burn surgery over the past 50 years in China

WANG Shiliang

《医学前沿（英文）》 2008年第2卷第4期页码 332-336 doi: 10.1007/s11684-008-0063-5

摘要： This paper reflects on the advancements of clinical and scientific research in the field of burn surgery in China. It includes emergency care of massive burns, resuscitation, anti-infection, prevention and cure of internal organ injuries, metabolic and nutritional support, wound repair and rehabilitation, and special types of burns; it also covers pathology, microbiology, immunology, cell biology, molecular biology, and tissue engineering.

关键词： immunology scientific nutritional microbiology engineering

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预腐蚀后拉伸超载对LC4CS铝合金疲劳性能的影响

蒋荟,杨晓华

《中国工程科学》 2006年第8卷第2期页码 44-46

摘要：

采用预腐蚀后进行单次拉伸超载疲劳试验的方法，研究了腐蚀与超载对LC4CS材料疲劳寿命的影响。

关键词： LC4CS 铝合金预腐蚀超载疲劳寿命

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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

《医学前沿（英文）》 2022年第16卷第6期页码 883-895 doi: 10.1007/s11684-022-0919-0

摘要： Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcoma. Identifying the relevant factors that drive metastasis and drug resistance is the key to improving the therapeutic outcome of osteosarcoma. Here, we reported that autophagy was highly activated in metastatic osteosarcoma. We found increased autophagolysosomes in metastatic osteosarcoma cell lines by using electron microscopy, Western blot, and immunofluorescence experiments. We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients through immunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis of osteosarcoma. Knockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcoma cells. In vitro and in vivo studies also demonstrated that inhibiting by 3-MA inhibited cell growth and metastasis. Moreover, we demonstrated that autophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1 decreased the metastasis of osteosarcoma. Overall, our findings highlighted the association of autophagy with osteosarcoma progression and shed new light on autophagy-targeting therapy for osteosarcoma.

关键词： osteosarcoma autophagy metastasis drug resistance Beclin1 LC3B

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人工智能破解生物学50年来的一个重大挑战

Sean O´Neill

《工程（英文）》 2021年第7卷第6期页码 706-708 doi: 10.1016/j.eng.2021.04.003

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MSWNet: A visual deep machine learning method adopting transfer learning based upon ResNet 50 for municipal

《环境科学与工程前沿（英文）》 2023年第17卷第6期 doi: 10.1007/s11783-023-1677-1

摘要：

● MSWNet was proposed to classify municipal solid waste.

关键词： Municipal solid waste sorting Deep residual network Transfer learning Cyclic learning rate Visualization

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Clinical characteristics in lymphangioleiomyomatosis-related pulmonary hypertension: an observation on 50

Xiuxiu Wu, Wenshuai Xu, Jun Wang, Xinlun Tian, Zhuang Tian, Kaifeng Xu

《医学前沿（英文）》 2019年第13卷第2期页码 259-266 doi: 10.1007/s11684-018-0634-z

摘要： Lymphangioleiomyomatosis (LAM) is a rare diffuse cystic lung disease. Knowledge on LAM-related pulmonary hypertension (PH) is limited. This study aimed to analyze the clinical characteristics of LAM with elevated pulmonary artery pressure (PAP) and evaluate the potential efficacy of sirolimus. The study involved 50 LAM patients who underwent echocardiography. According to the tricuspid regurgitation velocity (TRV), these patients were divided into the TRV≤2.8 m/s group and TRV>2.8 m/s group. Both groups comprised 25 females with an average age of 38.6±8.1 and 41.5±8.9 years. In the TRV>2.8 m/s group, the estimated systolic PAP (SPAP) was significantly elevated (52.08±12.45 mmHg vs. 30.24±5.25mmHg, <0.01). Linear analysis showed that SPAP was correlated with forced expiratory volume in 1 s (FEV ), diffusing capacity of the lungs for carbon monoxide, alveolar arterial oxygen gradient (P O ), and 6 min walking distance ( = −0.392, −0.351, 0.450, and −0.591, respectively; <0.05), in which P O was a risk factor for SPAP elevation ( = 0.064, OR= 1.066, <0.05). Moreover, in 10 patients who received sirolimus therapy, SPAP decreased from 57.0±12.6 mmHg to 35.2±11.1 mmHg. The study showed that LAM patients with PH exhibit poor pulmonary function and hypoxemia and may benefit from sirolimus treatment.

关键词： lymphangioleiomyomatosis pulmonary hypertension pulmonary function hypoxemia sirolimus

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基于大气阻力的立方星编队飞行非线性规划控制算法 Article

Sheng-chao DENG, Tao MENG, Zhong-he JIN

《信息与电子工程前沿（英文）》 2017年第18卷第7期页码 867-881 doi: 10.1631/FITEE.1500493

摘要：本文提出一种通过大气阻力实现轨道面内沿迹跟飞编队的综合策略，并将用于浙江大学下一颗皮纳卫星（该卫星是国际QB50项目成员之一）。QB50项目主要任务是90–300 km高度近地大气层探测。在这一轨道高度，大气阻力对卫星姿态和轨道的影响均不能忽略。

关键词： QB50；ZJUCubeSat；大气阻力；编队飞行

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Phase equilibrium of the ternary system of NH 4 Cl—CaCl 2 —H 2 O at 50°C

Xia LI, Junsheng YUAN, Zhiyong JI, Jianxin CHEN,

《化学科学与工程前沿（英文）》 2010年第4卷第1期页码 75-77 doi: 10.1007/s11705-009-0296-0

摘要： The equilibrium data on the ternary system of NHCl—CaCl—HO at 50°C were investigated using the wet-residue method. The experimental results show that there are three pure phase crystal areas of NHCl, 2NHCl·CaCl·3HO and CaCl·2HO, two mixture phase crystal areas of NHCl and 2NHCl·CaCl·3HO, and 2NHCl·CaCl·3HO and CaCl·2HO in the system. A new hydration double salt (2NHCl·CaCl·3HO) was found in the ternary equilibrium system for the first time.

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LC/MS/MS and radioisotope method combined for recognizing the affinity between catalpol and OCT2 transporter

Zhiyu ZHANG, Changxiao LIU, Duanyun SI, Rong LU, Xiulin YI

《化学科学与工程前沿（英文）》 2012年第6卷第4期页码 436-442 doi: 10.1007/s11705-012-1222-4

摘要： More and more herbal medicines are found to be the substrates of drug transporters. In this paper, chromatography/tandem mass spectrometry (LC/MS/MS) combined with radioisotope method was used for the quantification of catalpol, a traditional Chinese medicine, to study the affinity relationship between herbal medicines and transporters. Catalpol uptake experiment was carried out by using several transporters (OAT1, OCT2, OAT3, OATP1B1 and OATP2B1). And samples were precipitated with methanol and quantified with LC/MS/MS. The results show that catalpol has a good affinity with OCT2-transfected S2 cells. After studying drug-drug interaction between catalpol and C-tetraethylammonium (TEA), we found that catalpol is able to facilitate TEA transport mediated by OCT2, suggesting that catalpol could probably be a new promoter of OCT2.

关键词： catalpol LC/MS/MS OCT2

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A 50-year sedimentary record of heavy metals and their chemical speciations in the Shuangtaizi River

Baolin LIU, Ke HU, Zhenglong JIANG, Fengge QU, Xin SU

《环境科学与工程前沿（英文）》 2011年第5卷第3期页码 435-444 doi: 10.1007/s11783-011-0352-0

摘要： Two parallel sediment cores collected from tidal flat located in the Shuangtaizi River estuary were analyzed for heavy metal concentrations and chemical speciations. Based on the Cs activity profile, mean sedimentation rate at the sampling site during the past 50 years was estimated to be 1.3 cm·a . Correlation analyses show that almost all the metals are associated with each other, suggesting that these metals might be derived from same sources and/or affected by same geochemical processes. Influence of total organic carbon (TOC) content on the concentrations of Cr, Ni, Cu and Cd is evident. Silt and clay contents, instead of sand content, play an important role in the distribution of these metals. The dominant binding phases for most of the metals (except for Cd) are the residual. The relative decrease of the residual fraction of Cd and Pb in the upper 66 cm of the core is striking. The distribution of chemical fraction confirms that the residual fractions of these metals have a natural origin, while only the non-residual fractions of Cd and Pb increased upward the core due to pollution in the past five decades. Pollution assessment on these heavy metals based on Index of Geoaccumulation ( ) also demonstrates that most of the metals are unpolluted. The weak pollution as observed in the sediments is perhaps related to a local plant, the Kitag, which may have played a significant role in the biodegradation of these metals and the metal distribution in the estuary.

关键词： Shuangtaizi River estuary sediment core heavy metals pollution

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Autoimmune regulator regulates autophagy in THP-1 human monocytes

Liang SHI, Li-Hua HU, Yi-Rong LI

《医学前沿（英文）》 2010年第4卷第3期页码 336-341 doi: 10.1007/s11684-010-0096-4

摘要： The autoimmune regulator (AIRE) is a crucial factor for the induction of central tolerance, and mutations in this gene lead to abnormal immune responses. However, the role of AIRE in autophagy in immune cells, especially in monocytes, is obscure. In the present study, we found that overexpression of AIRE in THP-1 human monocytes resulted in increased endogenous light chain 3 (LC3)-II level and elevated LC3 positive vesicles. Moreover, an autophagy inhibitor or knockdown of AIRE by small interference RNA attenuated these effects. In contrast, the expression of p62/SQSTM1 remained unchanged in THP-1 cells after the corresponding treatment. Our findings indicate that AIRE plays a role in the regulation of autophagy in THP-1 human monocytes.

关键词： autoimmune regulator autophagy monocytes light chain 3 (LC3)