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Antioxidant and antitumor effects and immunomodulatory activities of crude and purified polyphenol extract

Xiaohong Kou,Lihua Han,Xingyuan Li,Zhaohui Xue,Fengjuan Zhou

《化学科学与工程前沿（英文）》 2016年第10卷第1期页码 108-119 doi: 10.1007/s11705-016-1553-7

摘要： The antioxidant and antitumor effects as well as the immunomodulatory activities of crude and purified polyphenol extract from blueberries were investigated. The antioxidant and antitumor effects of the polyphenol extract were measured both and , and their effect on the immune systems of CD-1 tumor-bearing mice were also analyzed. assays demonstrated that blueberry purified polyphenol extract (BBPP) exhibited higher antioxidant activities than blueberry crude polyphenol extract (BBCP), but the opposite effect was observed . Both the and antitumor activity and the immunity assay showed that BBCP not only inhibited tumor growth, but also significantly improved the immunity of the mice. According to physical and histological studies, the CD-1 tumor-bearing mice treated with the polyphenol extract, especially high doses of BBCP experienced a higher quality of life than the positive control group (treated with cyclophosphamide). These results indicate that BBCP has significant antioxidant and antitumor activities and that it can enhance the immunity of CD-1 tumor-bearing mice.

关键词： crude polyphenol extract purified polyphenol extract blueberry antioxidant antitumor immunity

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Evolution of humic substances in polymerization of polyphenol and amino acid based on non-destructive

Jianmei Zou, Jianzhi Huang, Huichun Zhang, Dongbei Yue

《环境科学与工程前沿（英文）》 2021年第15卷第1期 doi: 10.1007/s11783-020-1297-y

摘要： Abstract • Humification evolution was identified with non-destructive characterization method. • Humification process from precursors to fulvic and humic acid was confirmed. • MnO2 alone had limited oxidation ability to form HA. • MnO2 played a key role as a catalyst to transform FA to HA in the presence of O2. • MnO2 could affect the structure of the humification products. Abiotic humification is important in the formation and evolution of organic matter in soil and compost maturing processes. However, the roles of metal oxides in abiotic humification reactions under micro-aerobic remain ambiguous. The aim of this study was to use non-destructive measurement methods to investigate the role of MnO2 in the evolution of humic substances (HSs) during oxidative polymerization of polyphenol-amino acid. Our results suggested a synergistic effect between MnO2 and O2 in promoting the polymerization reaction and identified that MnO2 alone had a limited ability in accelerating the transformation of fulvic acid (FA) to humic acid (HA), whereas O2 was the key factor in the process. Two-dimensional correlation spectroscopy (2D-COS) showed that the evolution in the UV-vis spectra followed the order of 475–525 nm>300–400 nm>240–280 nm in the humification process, indicating the formation of simple organic matter followed by FA and then HA. 13C nuclear magnetic resonance (13C NMR) analysis revealed that the products under both air and N2 conditions in the presence of MnO2 had greater amounts of aromatic-C than in the absence of MnO2, demonstrating that MnO2 affected the structure of the humification products. The results of this study provided new insights into the theory of abiotic humification.

关键词： Two-dimensional correlation spectroscopy (2D-COS) Humic substances (HSs) Humification Manganese dioxide Polyphenol