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《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 112-120 doi: 10.1007/s11705-021-2075-5
关键词: fluorescent drug lysosomal anticancer zebrafish nude-mouse tumour imaging
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 67-78 doi: 10.1007/s11684-012-0176-8
Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy, resulting in tumor recurrence in patients after several months of treatment. Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues, which fosters tumor cells to become more aggressive and metastatic. In 2001, Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers. At present, normalizing the disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancer therapy. Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies, proteins, peptides, small molecules, and pericytes resulted in decreased tumor size and reduced metastasis. However, current tumor vascular normalizing drugs display moderate anticancer efficacy. Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization, growth, and metastasis. Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization. To this end, the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics, as well as the integration of Western medicine with traditional Chinese medicine, may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.
关键词: angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine
Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
《农业科学与工程前沿(英文)》 2015年 第2卷 第4期 页码 335-340 doi: 10.15302/J-FASE-2015079
关键词: b-pinene nopinone synthesis 2-amino-3-cyanopyridine anticancer
Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu
《环境科学与工程前沿(英文)》 2019年 第13卷 第4期 doi: 10.1007/s11783-019-1143-2
Specific second-order rate constants were determined for 5-FU and CAP with ozone. Reaction sites were confirmed by kinetics, Fukui analysis, and products. The olefin moiety was the main ozone reaction site for 5-FU and CAP. Carboxylic acids comprised most of the residual TOC for 5-FU. Ozonation removed the toxicity associated with 5-FU and products but not CAP.
关键词: Ozone 5-fluorouracil Capecitabine Hydroxyl radicals Chemotherapy agents Toxicity
《环境科学与工程前沿(英文)》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1501-8
• Oxidation of methotrexate by high-valent metal-oxo species was first explored.
关键词: Anticancer drugs High-valent metal-oxo species Oxidation kinetics Reaction mechanisms Multi-endpoint toxicity
标题 作者 时间 类型 操作
Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
期刊论文
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
期刊论文
Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
期刊论文
Ozonation of the 5-fluorouracil anticancer drug and its prodrug capecitabine: Reaction kinetics, oxidation
Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu
期刊论文