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《医学前沿(英文)》 2015年 第9卷 第3期 页码 261-274 doi: 10.1007/s11684-015-0406-y
Environmental pollution is one of the main causes of human cancer. Exposures to environmental carcinogens result in genetic and epigenetic alterations which induce cell transformation. Epigenetic changes caused by environmental pollution play important roles in the development and progression of environmental pollution-related cancers. Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancer. In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine were summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylation were introduced. Furthermore, prospective applications of DNA methylation to environmental pollution detection and cancer prevention were discussed.
关键词: environmental pollution DNA methylation cancer biomarker diagnosis therapy prevention
Stem cell research in hepatocellular carcinoma
SUN Chengyi, ZUO Shi
《医学前沿(英文)》 2008年 第2卷 第1期 页码 1-4 doi: 10.1007/s11684-008-0001-6
关键词: lineage hepato-pancreas differentiation block carcinogenesis current status
Mechanisms and impacts of chromosomal translocations in cancers
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 263-274 doi: 10.1007/s11684-012-0215-5
Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia. In the past few decades, tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations. This review focuses on the basic mechanisms underlying the generation of chromosomal translocations. In particular, the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.
关键词: DNA double strand breaks chromosomal translocations genomic instability spatial proximity carcinogenesis
标题 作者 时间 类型 操作
Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications
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