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Leptin signaling and leptin resistance
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 207-222 doi: 10.1007/s11684-013-0263-5
Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain, particularly in the hypothalamus. These LEPRb-expressing neurons function as the first-order neurons that project to the second-order neurons located within and outside the hypothalamus, forming a neural network that controls the energy homeostasis and body weight. Multiple factors, including inflammation and endoplasmic reticulum (ER) stress, contribute to leptin resistance. Leptin resistance is the key risk factor for obesity. This review is focused on recent advance about leptin action, leptin signaling, and leptin resistance.
关键词: leptin signaling leptin receptor energy balance leptin resistance obesity
Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene
Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 57-60 doi: 10.1007/s11684-009-0003-z
XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin
《医学前沿(英文)》 2007年 第1卷 第4期 页码 352-355 doi: 10.1007/s11684-007-0067-6
Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels
LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie
《医学前沿(英文)》 2007年 第1卷 第1期 页码 87-92 doi: 10.1007/s11684-007-0017-3
关键词: significant difference intestinal I/R transcriptase-polymerase metabolic central secretory
Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment
Jayshree Ashree, Qi Wang, Yimin Chao
《化学科学与工程前沿(英文)》 2020年 第14卷 第3期 页码 365-377 doi: 10.1007/s11705-019-1863-7
关键词: carbohydrate leptin glyco-functionalised QD bioimaging cancer diagnosis and treatment
标题 作者 时间 类型 操作
Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene
Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG
期刊论文
The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with
XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin
期刊论文
Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels
LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie
期刊论文