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Anna Khlyustova, Cédric Labay, Zdenko Machala, Maria-Pau Ginebra, Cristina Canal
《化学科学与工程前沿(英文)》 2019年 第13卷 第2期 页码 238-252 doi: 10.1007/s11705-019-1801-8
Low-dose CT for lung cancer screening: opportunities and challenges
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《医学前沿(英文)》 2018年 第12卷 第1期 页码 116-121 doi: 10.1007/s11684-017-0600-1
Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancer death in both males and females. Screening for lung cancer coupled with earlier intervention has long been studied as an approach to mortality reduction. However, minimal progress was achieved until recently, when low-dose spiral computed tomography (LDCT) screening demonstrated a 20% reduction in mortality from lung cancer in a randomized controlled trial (RCT), the National Lung Screening Trial, from the United States. On the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populations by several clinical guidelines. However, results from the following independent RCTs in Europe failed to show consistent conclusions. In addition, intractable problems gradually emerged with the progress of LDCT screening. This paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancer. Before spreading implementation of LDCT screening, challenges, including high false-positive rates, overdiagnosis, enormous costs, and radiation risk, must be addressed. Complementary biomarkers and technical improvement are expected in the field of lung cancer screening in the near future.
关键词: lung cancer low-dose computerized tomography early detection opportunities challenges
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 288-295 doi: 10.1007/s11684-012-0208-4
Tramadol is a potent analgesic. However, the analgesia efficacy of tramadol, particularly its minimum effective dose (MED), is not clear. The aim of this study is to find MED of tramadol for postoperative analgesia in infants. The continual reassessment method (CRM) was performed to find MED. Infants undergoing surgeries were included in the 3 phases of this series. In each phase, 24 participants were allocated a different tramadol dose. Pain intensity was measured by face, legs, activity, cry, consolability (FLACC) measurement at 3-hour intervals. Tramadol was considered ineffective if the FLACC score was higher than 4 in 10 at anytime. In phase 1, seven dose levels were used within the range 0.1–0.4 mg?kg-1·h-1. Phase 1 was insufficient to identify the MED, and we increased the dose to 0.4–0.8 mg?kg-1·h-1 in phase 2. Phase 2 was insufficient to identify the MED. In phase 3, local anesthetic wound infiltration was introduced, and the tramadol dose levels tested were the same as in phase 1. The successful analgesia probability of tramadol 0.4 mg?kg-1?h-1 was 82.1% (95% CI, 0.742–0.925) in phase 1. In phase 2, it was 84.7% (95% CI, 0.789–0.991) with the dose 0.8 mg?kg-1?h-1. Phase 1 and phase 2 were insufficient to identify the MED. In phase 3, the successful analgesia probability for dose 0.35 mg?kg-1?h-1was 96.7% (95% CI, 0.853–0.997).We have demonstrated that tramadol provides insufficient analgesia for surgeries considered to cause moderate-to-severe postoperative pain in infants if used as the sole analgesic, and that local anesthetic wound infiltration enhances the efficacy of tramadol.
关键词: tramadol minimum effective dose postoperative analgesia infants continual reassessment method
《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1733-x
关键词: Bioaugmentation Low-dose persulfate oxidation Polycyclic aromatic hydrocarbon Remediation
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization
《医学前沿(英文)》 2022年 第16卷 第1期 页码 93-101 doi: 10.1007/s11684-021-0914-x
关键词: COVID-19 SARS-CoV-2 vaccine immunization booster immunization
ZHANG Huilan, WANG Daowen
《医学前沿(英文)》 2008年 第2卷 第1期 页码 11-14 doi: 10.1007/s11684-008-0003-4
Kinetic Monte Carlo simulations of plasma-surface reactions on heterogeneous surfaces
Daniil Marinov
《化学科学与工程前沿(英文)》 2019年 第13卷 第4期 页码 815-822 doi: 10.1007/s11705-019-1837-9
关键词: plasma-surface interaction kinetic Monte Carlo plasma nano technology
From plasma to plasmonics: toward sustainable and clean water production through membranes
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1809-1836 doi: 10.1007/s11705-023-2339-3
关键词: water treatment membrane-based process plasma treatment plasma polymerization plasmonic light-to-heat conversion
Atomistic simulations of plasma catalytic processes
Erik C. Neyts
《化学科学与工程前沿(英文)》 2018年 第12卷 第1期 页码 145-154 doi: 10.1007/s11705-017-1674-7
Plasma-catalysis: Is it just a question of scale?
J. Christopher Whitehead
《化学科学与工程前沿(英文)》 2019年 第13卷 第2期 页码 264-273 doi: 10.1007/s11705-019-1794-3
关键词: plasma catalysis plasma-activated catalysis non-thermal plasma CO2 conversion
Submerged arc plasma system combined with ozone oxidation for the treatment of wastewater containing
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1384-0
• Submerged arc plasma was introduced in terms of wastewater treatment.
关键词: Thermal plasma Submerged arc plasma Wastewater Ozone Phenol Highly energetic electron
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《医学前沿(英文)》 2013年 第7卷 第4期 页码 506-509 doi: 10.1007/s11684-013-0294-y
This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in the city of Lhasa, China. Seven out of the twenty-six hospitals registered with the Lhasa Health Bureau were included in the investigation. The entrance surface air Kerma (ESAK) of seven conventional screen-film radiology X-ray equipment in these hospitals was measured with a QA dosimeter in September 2012. The X-ray examinations were divided into three categories: PA (posterior-anterior) chest, upper/lower limb, and AP (anterior-posterior) lumbar spine. For each category, ESAKs were calculated and analyzed. The mean ESAK was 0.6 mGy for PA chest, 0.3 mGy for upper/lower limb, and 1.8 mGy for AP lumbar spine. In addition, the mean ESAK value recorded for PA chest X-ray examinations exceeded the corresponding value recommended by the International Atomic Energy Agency (0.4 mGy).
关键词: radiation dosage radiology radiation protection radiography/statistics & numerical data
Modelling and diagnostics of multiple cathodes plasma torch system for plasma spraying
Kirsten BOBZIN, Nazlim BAGCIVAN, Lidong ZHAO, Ivica PETKOVIC, Jochen SCHEIN, Karsten HARTZ-BEHREND, Stefan KIRNER, José-Luis MARQUéS, Günter FORSTER
《机械工程前沿(英文)》 2011年 第6卷 第3期 页码 324-331 doi: 10.1007/s11465-011-0125-2
Usage of a multiple-arcs system has significantly improved process stability and coating properties in air plasma spraying. However, there are still demands on understanding and controlling the physical process to determine process conditions for reproducible coating quality and homogeneity of coating microstructure. The main goal of this work is the application of numerical simulation for the prediction of the temperature profiles at the torch outlet for real process conditions. Behaviour of the gas flow and electric arcs were described in a three-dimensional numerical model. The calculated results showed the characteristic triangular temperature distribution at the torch nozzle outlet caused by three electric arcs. These results were compared with experimentally determined temperature distributions, which were obtained with specially developed computed tomography equipment for reconstructing the emissivity and temperature distribution of the plasma jet close to the torch exit. The calculated results related to temperature values and contours were verified for the most process parameters with experimental ones.
关键词: plasma spraying electric arc three-cathode plasma torch numerical simulation computed tomography
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《医学前沿(英文)》 2014年 第8卷 第4期 页码 477-483 doi: 10.1007/s11684-014-0346-y
The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects (1027 men, and 2433 women, aged 35–75 years old) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376±0.018; middle tertiles, 5.324±0.018; highest tertiles, 5.276±0.018 mmol/L; P=0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75; 95% CI: 1.20--2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.
关键词: dyslipidemia plasma lipids plasma fasting glucose impaired fasting glucose non-diabetes
《医学前沿(英文)》 doi: 10.1007/s11684-023-1022-x
关键词: acute promyelocytic leukemia plasma proteomics plasma metabolomics cross-sectional correlation network pathogenesis treatment
标题 作者 时间 类型 操作
Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief
Anna Khlyustova, Cédric Labay, Zdenko Machala, Maria-Pau Ginebra, Cristina Canal
期刊论文
Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the
null
期刊论文
Comparison of exogenous degrader-enhanced bioremediation with low-dose persulfate oxidation for polycyclic
期刊论文
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization
期刊论文
Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism
ZHANG Huilan, WANG Daowen
期刊论文
Kinetic Monte Carlo simulations of plasma-surface reactions on heterogeneous surfaces
Daniil Marinov
期刊论文
Submerged arc plasma system combined with ozone oxidation for the treatment of wastewater containing
期刊论文
An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous
null
期刊论文
Modelling and diagnostics of multiple cathodes plasma torch system for plasma spraying
Kirsten BOBZIN, Nazlim BAGCIVAN, Lidong ZHAO, Ivica PETKOVIC, Jochen SCHEIN, Karsten HARTZ-BEHREND, Stefan KIRNER, José-Luis MARQUéS, Günter FORSTER
期刊论文
Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic
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期刊论文