Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 8

年份

2020 1

2018 1

2017 1

2016 3

2014 2

关键词

一致性哈希表；副本布局；能源管理；键值存储系统；可靠性 1

数据云；复制；图形；位置复制管理器 1

高性能计算；主动容错；故障局部性；进程复制；进程预取 1

检索范围：

排序：展示方式：

基于位置的数据云复制管理器 Article

Reza SOOKHTSARAEI,Javad ARTIN,Ali GHORBANI,Ahmad FARAAHI,Hadi ADINEH

《信息与电子工程前沿（英文）》 2016年第17卷第12期页码 1275-1286 doi: 10.1631/FITEE.1500391

摘要：我们提出了一种可减少资源、能源消耗，减少系统延迟，并增加系统可用性的复制管理器，称为位置复制管理器（Locality replication manager, LRM）。

关键词：数据云；复制；图形；位置复制管理器

HTML PDF 收藏

Dynamics of foot-and-mouth disease virus replication in cells at different phases of the cell-division

Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN

《农业科学与工程前沿（英文）》 2014年第1卷第3期页码 250-257 doi: 10.15302/J-FASE-2014031

摘要： Foot-and-mouth-disease virus (FMDV) replicates in epithelial cells. The restriction of FMDV RNA to the basal cell layer of epithelia suggests a possible link between FMDV replication and the cell status. This paper describes studies in which FMDV infection was investigated in cells that were held at various cell division phases using cell cycle inhibitors. The results suggest that when cells were arrested at the G or G /S phase, high levels of viral RNA were detected by quantitative real-time reverse transcription PCR and viral protein synthesis was observed by specific labeling techniques. In contrast, when cells were arrested at the G /M phase, reduced or no viral RNA synthesis was detected.

关键词： foot-and-mouth disease virus cell cycle replication

HTML PDF 收藏

Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission

null

《医学前沿（英文）》 2017年第11卷第4期页码 548-553 doi: 10.1007/s11684-017-0597-5

摘要：

This study determined the effect of hepatitis B virus (HBV) replication in peripheral blood mononuclear cell (PBMC) from HBsAg-positive mothers on HBV intrauterine transmission. A total of 150 HBsAg-positive mothers and their neonates were recruited in this study. Within 24 h after birth, HBV serological markers, serum HBV DNA, PBMC HBV relaxed circular DNA (rcDNA), and covalently closed circular DNA (cccDNA) were measured in the HBsAg-positive mothers and their neonates before passive-active immune prophylaxis. The relationship between HBV replication in PBMC and HBV intrauterine transmission was examined through Chi-square test and logistic regression. The rate of HBV intrauterine transmission was 8.00% (12/150) in the 150 neonates born to HBsAg-positive mothers. The positivities of PBMC HBV rcDNA and cccDNA in the HBsAg-positive mothers were 36.67% (55/150) and 10% (15/150), respectively. Maternal PBMC HBV cccDNA was a risk factor of HBV intrauterine transmission (OR= 6.003, 95% CI: 1.249–28.855). Maternal serum HBeAg was a risk factor of PBMC HBV rcDNA (OR= 3.896, 95% CI: 1.929–7.876) and PBMC HBV cccDNA (OR= 3.74, 95% CI: 1.186–11.793) in the HBsAg-positive mothers. Administration of hepatitis B immune globulin was a protective factor of PBMC HBV cccDNA (OR= 0.312, 95% CI: 0.102–0.954) during pregnancy. The positivity of PBMC HBV rcDNA was related to that of cccDNA in the HBsAg-positive mothers (c²=5.087, P= 0.024). This study suggests that PBMC is a reservoir of HBV and an extrahepatic site for virus replication and plays a critical role in HBV intrauterine transmission.

关键词： PBMC HBV cccDNA HBV rcDNA HBV intrauterine transmission

HTML PDF 收藏

FTRP：基于进程复制和预取的高性能计算容错框架 Research

Wei HU, Guang-ming LIU, Yan-huang JIANG

《信息与电子工程前沿（英文）》 2018年第19卷第10期页码 1273-1290 doi: 10.1631/FITEE.1601450

摘要：为此，提出一种基于进程复制和预取的高性能计算容错框架—FTRP（fault tolerance framework using process replication and prefetching），

关键词：高性能计算；主动容错；故障局部性；进程复制；进程预取

HTML PDF 收藏

Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

《化学科学与工程前沿（英文）》 2016年第10卷第2期页码 186-195 doi: 10.1007/s11705-015-1540-4

摘要： Increased expression levels of the RNA splicing regulator Transformer2 (abbreviated Tra2 ) have been reported in several types of cancer. Recent work has revealed an intimate cross-regulation between Tra2 and the highly similar Tra2 protein in human breast cancer cells, though these two proteins are encoded by separate genes created by a gene duplication that occurred over 500 million years ago. This cross-regulation involves splicing control of a special class of exons, called poison exons. Down-regulation of Tra2 reduces splicing inclusion of a poison exon in the mRNA encoding Tra2 , thereby up-regulating Tra2 protein expression. This buffers any splicing changes that might be caused by individual depletion of Tra2 alone. Discovery of this cross-regulation pathway, and its by-pass by joint depletion of both human Tra2 proteins, revealed Tra2 proteins are essential for breast cancer cell viability, and led to the identification of important targets for splicing control. These exons include a critical exon within the checkpoint kinase 1 (CHK1) gene that plays a crucial function in the protection of cancer cells from replication stress. Breast cancer cells depleted for Tra2 proteins have reduced CHK1 protein levels and accumulate DNA damage. These data suggest Tra2 proteins and/or their splicing targets as possible cancer drug targets.

关键词： RNA splicing gene expression breast cancer DNA damage CHK1

HTML PDF 收藏

A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

《农业科学与工程前沿（英文）》 2014年第1卷第4期页码 321-330 doi: 10.15302/J-FASE-2014037

摘要： Genome-wide association studies with an Illumina Bovine50K chip have detected 105 SNPs associated with one or multiple milk production traits in the Chinese Holstein population. Of these, 38 significant SNPs detected with high confidence by both L1-TDT and MMRA methods were selected to further mine potential key genes affecting milk yield and milk composition. By blasting the flanking sequences of these 38 SNPs with the bovine genome sequence combined with comparative genomics analysis, 26 genes were found to contain or be near to such SNPs. Among them, the gene is merely 87 bp away from the significant SNP, Hapmap30383-BTC-005848. Hence, we report herein genotype-phenotype associations to further validate the genetic effects of the gene. By pooled DNA sequencing of 14 unrelated Holstein sires, a total of 18 with seven novel SNPs were identified. Among them, nine SNPs were in the 5′ regulatory region, one in exon 6 and the other in the 3′ UTR and 3′ regulatory region. A total of nine of these identified SNPs were successfully genotyped and analyzed by mass spectrometry for association with five milk production traits in an independent resource population. The results showed that these SNPs were statistically significant for more than two traits [ <(0.0001-0.0267)]. In addition, mRNA expression analyses revealed that was ubiquitous in eight different tissues, with a relatively higher expression level in the mammary gland than in other tissues. These findings, therefore, provide strong evidence for association of variants with milk yield and milk composition traits and may be applied in Chinese Holstein breeding programs.

关键词： GWAS functional annotation Chinese Holstein milk production traits C14H8orf33 gene single nucleotide polymorphisms association study

HTML PDF 收藏

Option-like properties in the distribution of hedge fund returns

Katharina DENK, Ben DJERROUD, Luis SECO, Mohammad SHAKOURIFAR, Rudi ZAGST

《工程管理前沿（英文）》 2020年第7卷第2期页码 275-286 doi: 10.1007/s42524-020-0095-3

摘要： Hedge funds have recently become popular because of their low correlation with traditional investments and their ability to generate positive returns with a relatively low volatility. However, a close look at those high-performing hedge funds raises the questions on whether their performance is truly superior and whether the high management fees are justified. Incurring no alpha costs, passive hedge fund replication strategies raise the question on whether they can similarly perform by improving efficiency at reduced costs. Therefore, this study investigates two different model approaches for the equity long/short strategy, where weighted segmented linear regression models are employed and combined with two-state Markov switching models. The main finding proves a short put option structure, i.e., short equity market volatility, with the put structure present in all market states. We obtain an evidence that the hedge fund managers decrease their short-volatility profile during turbulent markets.

关键词： hedge funds hedge fund index segmented linear regression models regime-switching models mimicking portfolios single factor-based hedge fund replication equity long–short strategy

HTML PDF 收藏

一种针对基于一致性哈希的键值存储系统的低能耗副本布局策略 Article

Nan-nan ZHAO,Ji-guang WAN,Jun WANG,Chang-sheng XIE

《信息与电子工程前沿（英文）》 2016年第17卷第10期页码 994-1007 doi: 10.1631/FITEE.1601162

摘要：概要：分布式键值存储作为最常用的分布式存储系统之一，目前广泛部署在大规模数据中心中。然而，大规模数据中心的高能耗是一个亟待解决的问题。为达到较好节能效果，同时满足数据可用性要求，本文提出一个针对基于一致性哈希的分布式键值存储系统的低能耗副本布局策略——GreenCHT，它包括一个分层副本布局方案、一个可靠的分布式日志和一个预测能耗模式调节器。GreenCHT将副本分布在互不重叠的多个节点层，而非随机放置于哈希环的部分节点。在分层副本布局中，部分节点层可以维持活动状态，其他节点可以被关闭而不影响数据可用性，以达到节能目的。能耗模式调节器（power mode scheduler, PMS）能够预测I/O负载，并根据负载高低波动变化，相应关闭或开启某些节点层。为保证节能状态下的系统可靠性，对于待机副本的写请求，被重新映射到活动的服务器，以保证系统的容错性。通过修改Sheepdog原有的数据分布算法和副本布局策略，GreenCHT被配置在Sheepdog存储集群中。实验中，GreenCHT能够节省35%–61%能耗，同时维持较好性能和可靠性。

关键词：一致性哈希表；副本布局；能源管理；键值存储系统；可靠性

HTML PDF 收藏

标题作者时间类型操作

基于位置的数据云复制管理器

Reza SOOKHTSARAEI,Javad ARTIN,Ali GHORBANI,Ahmad FARAAHI,Hadi ADINEH

期刊论文

Dynamics of foot-and-mouth disease virus replication in cells at different phases of the cell-division

Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN

期刊论文

Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission

null

期刊论文