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期刊论文 7

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临床特征 1

微生物组 1

新型冠状病毒肺炎（COVID-19） 1

新型冠状病毒（SARS-CoV-2） 1

症状 1

肝硬化 1

胃镜 1

静脉曲张 1

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Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

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《医学前沿（英文）》 2016年 第10卷 第3期   页码 345-350 doi: 10.1007/s11684-016-0462-y

摘要：

Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran. The prevalence rate was compared according to age group (aged 6–7 years vs. aged 13–14 years) and gender (male vs. female). In this cross-sectional study, 1706 Iranian schoolchildren aged 6–7 and 13–14 years in Golestan Province were enrolled. Participants completed questionnaires between February and July 2014. Asthma symptoms were assessed using the questionnaire of the International Study of Asthma and Allergies in Childhood protocol in Persian. The logistic regression model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the asthma symptoms for each of the gender and age groups. The prevalence rates of “current asthma” symptoms and “asthma ever” in all the children were estimated as 9.5% and 7.5%, respectively. The prevalence of asthma (“asthma ever” and “wheezing in the past 12 months”) in junior high schoolchildren (aged 13–14 years) is higher than that in elementary schoolchildren (aged 6–7 years) (P <0.05). The prevalence of the severity of wheezing in girls is lower than that in boys (OR= 1.7, 95%CI= 1.06–2.96, P = 0.02). Asthma is still a major public health problem. This study shows that the prevalence of the asthma symptoms in boys is lower than that in girls in both age groups, and the severity of asthma in girls is higher than that in boys aged 13–14 years.

关键词： asthma     asthma symptoms     epidemiology     childhood     chronic disease    

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Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

《医学前沿（英文）》 2022年 第16卷 第6期   页码 919-931 doi: 10.1007/s11684-021-0918-6

摘要： Preeclampsia (PE) is characterized by placenta-mediated pregnancy complication. The only effective treatment for PE is the delivery of the placenta. However, this treatment may cause preterm birth and neonatal death. Therefore, preventing PE is needed. The mechanism of PE involves abnormal placentation, which leads to the release of anti-angiogenic and inflammatory mediators into maternal circulation. These mediators contribute to systemic vascular dysfunction, inflammatory responses, and excessive thrombin generation. Microparticles (MPs) are reportedly involved in PE by promoting the thromboinflammatory response. This study describes a strategy to prevent PE by reducing MP release using the recombinant protein, diannexin. Results showed that the patients with PE had elevated MP number and procoagulant activity and increased NLRP3 inflammasome activation. Additionally, diannexin remarkably reduced the release of MPs from activated cells by binding to phosphatidylserine exposed on the surface of activated cells. Moreover, in vivo results showed that diannexin could prevent PE-like symptoms by decreasing MPs and NLRP3 inflammasome activation in pregnant mice. Furthermore, diannexin effectively inhibited trophoblast cell activation and NLRP3 inflammasome activation in vitro. These findings suggested that diannexin inhibited MP release and might be an effective therapeutic strategy for preventing PE.

关键词： preeclampsia     recombinant protein diannexin     microparticle     NLRP3 inflammasome     phosphatidylserin    

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肝硬化患者胃黏膜微生物菌群特征及其与胃肠道症状的相关性分析 Article

陈燕飞, 郭静, 陈春雷, 石鼎, 方戴琼, 季峰, 李兰娟

《工程（英文）》 2021年 第7卷 第4期   页码 507-514 doi: 10.1016/j.eng.2020.04.014

摘要：

研究表明，肝硬化患者的口腔和肠道微生物群与健康人群存在差异。胃位于口腔和肠道之间，关于其黏膜微生物群结构所知甚少。本研究采用16S rRNA焦磷酸测序技术分析了肝硬化患者和对照组的胃黏膜微生物群。研究发现，组织学和测序法均证实肝硬化患者幽门螺杆菌感染率显著降低。在幽门螺杆菌阴性人群中，可以按细菌组成结构将胃黏膜微生物群分为4个聚类，其中聚类1和2主要是肝硬化患者，聚类3主要是健康人群，而聚类4中肝硬化患者和健康人群各占一半左右。这些不同聚类间的成分和功能存在显著差异。在属的水平上，聚类1和2分别富集奈瑟菌和链球菌。在功能基因分类上，相对而言，聚类2缺乏涉及遗传信息处理以及与聚糖生物合成和代谢相关的功能基因。胃黏膜菌群结构表现为聚类2的患者胃肠道症状更严重，既往内镜下曲张静脉的治疗率显著高于其他组。我们的研究结果表明，在肝硬化中，幽门螺杆菌和非幽门螺杆菌的定植都受到影响。虽然幽门螺杆菌阴性的胃黏膜微生物结构表现出相当大的异质性，但特定的胃微生物群与临床特征之间仍然存在相关性。既往内镜下静脉曲张治疗会引起胃黏膜菌群结构明显改变，从而加重幽门螺杆菌阴性肝硬化患者的胃肠道症状。

关键词： 微生物组     肝硬化     症状     静脉曲张     胃镜    

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A giant Müllerian duct cyst in the perineum: a case report

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《医学前沿（英文）》 2012年 第6卷 第4期   页码 440-443 doi: 10.1007/s11684-012-0222-6

摘要：

The authors present a case report of a giant Müllerian duct cyst in the perineum. A 37-year-old man presented with a mass with the size of 50 cm×40 cm×30 cm in the perineum. Computed tomography (CT) scan and magnetic resonance imaging (MRI) of the pelvis and perineum found a huge multilocular cystic mass. X-ray film of the pelvis showed a giant soft-tissue shadow of high density in the perineum. Voiding cystourethrogram did not show any cyst interlinked to posterior urethra. After related examinations, the patient underwent open surgical resection of the cyst. Pathologic examination confirmed the presence of a Müllerian duct cyst. Huge Müllerian duct cyst is uncommon in clinic. Treatments of Müllerian duct cysts depend on their sizes and symptoms.

关键词： Müllerian duct cyst     clinical symptoms     diagnosis    

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Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural

Won-Mo Jung, In-Soo Park, Ye-Seul Lee, Chang-Eop Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Park, Bo-Hyoung Jang, Younbyoung Chae

《医学前沿（英文）》 2019年 第13卷 第1期   页码 112-120 doi: 10.1007/s11684-017-0582-z

摘要： Comprehension of the medical diagnoses of doctors and treatment of diseases is important to understand the underlying principle in selecting appropriate acupoints. The pattern recognition process that pertains to symptoms and diseases and informs acupuncture treatment in a clinical setting was explored. A total of 232 clinical records were collected using a Charting Language program. The relationship between symptom information and selected acupoints was trained using an artificial neural network (ANN). A total of 11 hidden nodes with the highest average precision score were selected through a tenfold cross-validation. Our ANN model could predict the selected acupoints based on symptom and disease information with an average precision score of 0.865 (precision, 0.911; recall, 0.811). This model is a useful tool for diagnostic classification or pattern recognition and for the prediction and modeling of acupuncture treatment based on clinical data obtained in a real-world setting. The relationship between symptoms and selected acupoints could be systematically characterized through knowledge discovery processes, such as pattern identification.

关键词： acupuncture     indication     neural network     pattern identification     prediction    

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Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

《医学前沿（英文）》 2020年 第14卷 第3期   页码 357-367 doi: 10.1007/s11684-019-0699-3

摘要： Pediatric cough is a heterogeneous condition in terms of symptoms and the underlying disease mechanisms. Symptom phenotypes hold complicated interactions between each other to form an intricate network structure. This study aims to investigate whether the network structure of pediatric cough symptoms is associated with the prognosis and outcome of patients. A total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinese medicine (TCM) physician. The data were divided into two groups according to the therapeutic effect, namely, an invalid group (group A with 40 cases of poor efficacy) and a valid group (group B with 344 cases of good efficacy). Several well-established analysis methods, namely, statistical test, correlation analysis, and complex network analysis, were used to analyze the data. This study reports that symptom networks of patients with pediatric cough are related to the effectiveness of treatment: a dense network of symptoms is associated with great difficulty in treatment. Interventions with the most different symptoms in the symptom network may have improved therapeutic effects.

关键词： pediatric cough     complex network     symptoms     traditional Chinese medicine     electronic medical records    

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起病时无呼吸道症状或发热的重型或危重型COVID-19患者的临床特征及转归 Article

许娟娟, 殷峥嵘, 刘宇, 汪速飞, 段丽敏, 安義, 范金烁, 廖婷婷, 金阳, 陈建国

《工程（英文）》 2021年 第7卷 第10期   页码 1454-1460 doi: 10.1016/j.eng.2020.09.009

摘要：

以不典型症状起病的新型冠状病毒肺炎（COVID-19）患者在早期容易漏诊，部分患者可发展为重症甚至危重症，目前尚缺乏相关的临床研究。本研究回顾了在起病时无典型症状（呼吸道症状或发热）的重型或危重型COVID-19患者的临床、实验室和影像学特征及治疗情况，并随访至患者死亡或治愈出院。2020年1月25日至2020年2月10日期间，武汉协和医院西院共收治943例COVID-19患者，其中909例（96.4%）重型或危重型COVID-19患者中有10例（1.1%）患者在起病时无呼吸系统症状或发热。10例患者的中位年龄为63岁[四分位区间（IQR）：57~72]，其中7例为男性。从出现症状到入院的中位时间为14 d（IQR：7~20）。10例患者中有8例患有慢性基础疾病。入院时，5例患者有乏力症状（n = 5）、4例有头痛或头晕（n = 4）、5例有腹泻（n = 5）、3例有厌食（n = 3）、3例有恶心或呕吐（n = 3）以及1例患者有眼部不适症状（n = 1）。4例患者外周血淋巴细胞减少。影像学检查显示9例患者有双侧肺炎，1例有单侧肺炎。最终2例患者死亡，8例患者治愈出院。8例患者从入院到出院的中位时间为24 d（IQR：13~43）。总的来说，部分重型或危重型COVID-19 患者在起病时无呼吸道症状或发热，此类不典型患者应尽早发现和隔离，否则可能延误病情，导致住院时间延长，甚至死亡。因此，对COVID-19患者密切接触者，即使无呼吸道症状或发热，也应及时进行核酸检测或胸部CT扫描以筛查不典型症状患者。

关键词： 新型冠状病毒（SARS-CoV-2）     新型冠状病毒肺炎（COVID-19）     不典型的     临床特征    

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标题 作者 时间 类型 操作

Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

null

期刊论文

Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

期刊论文

肝硬化患者胃黏膜微生物菌群特征及其与胃肠道症状的相关性分析

陈燕飞, 郭静, 陈春雷, 石鼎, 方戴琼, 季峰, 李兰娟

期刊论文

A giant Müllerian duct cyst in the perineum: a case report

null

期刊论文

Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural

Won-Mo Jung, In-Soo Park, Ye-Seul Lee, Chang-Eop Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Park, Bo-Hyoung Jang, Younbyoung Chae

期刊论文

Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

期刊论文

起病时无呼吸道症状或发热的重型或危重型COVID-19患者的临床特征及转归

许娟娟, 殷峥嵘, 刘宇, 汪速飞, 段丽敏, 安義, 范金烁, 廖婷婷, 金阳, 陈建国

期刊论文