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Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 67-78 doi: 10.1007/s11684-012-0176-8
Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy, resulting in tumor recurrence in patients after several months of treatment. Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues, which fosters tumor cells to become more aggressive and metastatic. In 2001, Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers. At present, normalizing the disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancer therapy. Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies, proteins, peptides, small molecules, and pericytes resulted in decreased tumor size and reduced metastasis. However, current tumor vascular normalizing drugs display moderate anticancer efficacy. Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization, growth, and metastasis. Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization. To this end, the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics, as well as the integration of Western medicine with traditional Chinese medicine, may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.
关键词: angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine
基于门控自编码器的驾驶行为量化评价标准化策略 Research Articles
何欣,张哲,许力,俞佳培
《信息与电子工程前沿(英文)》 2022年 第23卷 第3期 页码 452-462 doi: 10.1631/FITEE.2000667
关键词: 驾驶行为;标准化;门控自编码器;定量评价
Modeling, simulation, and prediction of global energy indices: a differential approach
Stephen Ndubuisi NNAMCHI, Onyinyechi Adanma NNAMCHI, Janice Desire BUSINGYE, Maxwell Azubuike IJOMAH, Philip Ikechi OBASI
《能源前沿(英文)》 2022年 第16卷 第2期 页码 375-392 doi: 10.1007/s11708-021-0723-6
关键词: energy indices differential model normalization simulation inflation/deflation predictive factor and prediction rate
一种基于子带激励替换的窄带语音水印算法 Article
Wei LIU, Ai-qun HU
《信息与电子工程前沿(英文)》 2017年 第18卷 第5期 页码 627-643 doi: 10.1631/FITEE.1601503
解钰茜,张林波,罗上华,杨娇,李芬,王德旺
《中国工程科学》 2017年 第19卷 第4期 页码 60-66 doi: 10.15302/J-SSCAE-2017.04.010
本文构建了包含4个领域、10个目标、25个指标的省域生态文明发展水平评估指标体系。在对比和改进现有数据标准化处理方法的基础上,提出双目标渐进法对评价指标进行归一化处理,并采用综合加权指数法对2014年我国的31个省、自治区、直辖市的生态文明发展水平进行评估。结果显示,我国生态文明发展水平较低,东南沿海地区生态文明发展水平高于中西部地区。总体来看,目前我国整体经济社会建设成效显著,但我国生态文明发展水平与预期目标及国际水平相比还有一定差距,因此在生态环境保护、工业污染控制、产业优化和资源高效利用方面还需加强。
标题 作者 时间 类型 操作
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
期刊论文
Modeling, simulation, and prediction of global energy indices: a differential approach
Stephen Ndubuisi NNAMCHI, Onyinyechi Adanma NNAMCHI, Janice Desire BUSINGYE, Maxwell Azubuike IJOMAH, Philip Ikechi OBASI
期刊论文