Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance

2007, Volume 1, Issue 2

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Frontiers of Medicine >> 2007, Volume 1, Issue 2 doi: 10.1007/s11684-007-0038-y

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive effect of Arachidonic acid on insulin resistance

1.Department of Medical Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2.Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;

Available online: 2007-06-05

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Abstract

Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2 diabetes mellitus. In this study, we investigated the effects of two fatty acids, palmitate (PA) and arach

Keywords

palmitate ; characteristic ; study ; plasma ; resistance

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