2016, Volume 10, Issue 1
Frontiers of Medicine >> 2016, Volume 10, Issue 1 doi: 10.1007/s11684-015-0427-6
Therapeutic application of hydrogen sulfide donors: the potential and challenges
1. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
2. Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
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Abstract
Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been considered a toxic gas and environment hazard. However, evidences show that H2S plays a great role in many physiological and pathological activities, and it exhibits different effects when applied at various doses. In this review, we summarize the chemistry and biomedical applications of H2S-releasing compounds, including inorganic salts, phosphorodithioate derivatives, derivatives of Allium sativum extracts, derivatives of thioaminoacids, and derivatives of anti-inflammatory drugs.
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