A brief review of microRNA and its role in PRRSV infection and replication

2014, Volume 1, Issue 2

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Frontiers of Agricultural Science and Engineering >> 2014, Volume 1, Issue 2 doi: 10.15302/J-FASE-2014022

A brief review of microRNA and its role in PRRSV infection and replication

State Key Laboratory of Agrobiotechnology, Ministry of Agriculture Key Laboratory of Soil Microbiology, Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing 100193, China

Available online: 2014-10-10

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Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV), a single-stranded RNA virus, mainly infects cells of monocyte/macrophage lineage. Recently, host microRNAs were shown to be capable of modulating PRRSV infection and replication by multiple ways such as targeting viral genomic RNA, targeting viral receptor and inducing antiviral response. MicroRNAs are small RNAs and have emerged as important regulators of virus-host cell interactions. In this review, we discuss the identified functions of host microRNAs in relation to PRRSV infection and propose that cellular microRNAs may have a substantial effect on cell or tissue tropism of PRRSV.

Keywords

porcine reproductive and respiratory syndrome virus (PRRSV) ; microRNA ; antiviral ; viral tropism

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