Effects of DNA damage on oocyte meiotic maturation and early embryonic development

2014, Volume 1, Issue 3

Abstract

Keywords

Related Research

Frontiers of Agricultural Science and Engineering >> 2014, Volume 1, Issue 3 doi: 10.15302/J-FASE-2014035

Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China

Accepted: 2015-01-16 Available online: 2015-01-27

HTML14 PDF 4 Collect 0

Next Previous

Abstract

DNA damage is one of the most common threats to meiotic cells. It has the potential to induce infertility and genetic abnormalities that may be passed to the embryo. Here, we reviewed exogenous factors which could induce DNA damage. Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic development. Complex DNA damage, double-strand breaks, represents a more difficult repair process and involves various repair pathways. Understanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for ovarian cancer and fertility preservation.

Keywords

DNA damage ; double-strand breaks (DSBs) ; oocyte ; embryo

Related Research