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Frontiers of Agricultural Science and Engineering >> 2014, Volume 1, Issue 2 doi: 10.15302/J-FASE-2014015
Depletion of conventional mature B cells and compromised specific antibody response in bovine immunoglobulin μ heavy-chain transgenic mice
1. State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.2. GeneProtein Biotech Ltd, Beijing 100193, China.3. School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.4. Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China
Abstract
Keywords
bovine Ig μ heavy-chain ; transgenic mice ; B cell development ; allelic exclusion ; immune response ; Ig repertoire
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