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CROP PROTECTION OPENS UP NEW ERA OF CONSERVATION AND UTILIZATION OF GREEN OPTIONS
Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, Pages 1-3 doi: 10.15302/J-FASE-2021431
Wheat research and breeding in the new era of a high-quality reference genome
Rudi APPELS
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3, Pages 225-232 doi: 10.15302/J-FASE-2019265
The publications of the International Wheat Genome Sequencing Consortium (IWGSC) released in August 2018 are reviewed and placed into the context of developments arising from the availability of the high-quality wheat genome assembly.
Keywords: assembly technology molecular markers polyploidy transcript networks wheat genome
Platform governance in the era of AI and the digital economy
Frontiers of Engineering Management 2023, Volume 10, Issue 1, Pages 177-182 doi: 10.1007/s42524-022-0241-1
Managing supply chain resilience in the era of VUCA
Ying GAO , Zhuo FENG , Shuibo ZHANG
Frontiers of Engineering Management 2021, Volume 8, Issue 3, Pages 465-470 doi: 10.1007/s42524-021-0164-2
Holistic integrative medicine: toward a new era of medical advancement
Daiming Fan
Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 152-159 doi: 10.1007/s11684-017-0499-6
Medicine has encountered unprecedented problems associated with changes in nature, society, and environment, as well as with new human quests for survival, longevity, and health. In the meantime, the development of medicine is facing challenges that resulted from the over-division and specialization of disciplines and the fragmentation of medical knowledge. To construct a new medical system that is more suitable for human health and disease treatment, holistic integrative medicine (HIM), which regards the human body as a holistic entity, organically integrates the most advanced knowledge and theories in each medical field and the most effective practices in various clinical specialties to revise and adjust on the basis of social, environmental, and psychological conditions. HIM is the inevitable and necessary direction for the future development of medicine. In this article, we illustrated the connotation of HIM, the differences between HIM and other medical conceptions, and the practice of HIM in recent years.
Keywords: holistic integrative medicine precision medicine general practice medicine
Exploring the cancer genome in the era of next-generation sequencing
Hui Dong, Shengyue Wang
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 48-55 doi: 10.1007/s11684-012-0182-x
The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genome studies. The increased efficiency and resolution of next-generation sequencing greatly facilitate the detection of genetic, genomic, and epigenomic alterations, such as single nucleotide mutations, small insertions and deletions, chromosomal rearrangements, copy number variations, and DNA methylation. Comprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptome sequencing has significantly improved the understanding of cancer biology, diagnosis, and therapy. The present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides an unprecedented insight into the landscape of genomic alterations in human sporadic cancers.
Keywords: next-generation sequencing cancer genome whole genome sequencing exome transcriptome
Servitization of manufacturing in the new ICTs era: A survey on operations management
Kangzhou WANG, Zhibin JIANG, Bo PENG, Hui JING
Frontiers of Engineering Management 2021, Volume 8, Issue 2, Pages 223-235 doi: 10.1007/s42524-020-0103-7
Keywords: servitization service-oriented manufacturing value chain resource integration supply chain ICT
Cell Therapy: Pharmacological Intervention Enters a Third Era
Wei He
Engineering 2019, Volume 5, Issue 1, Pages 5-9 doi: 10.1016/j.eng.2018.11.017
Ambient vibration testing and updating of the finite element model of a simply supported beam bridge
Ivan Gomez ARAUJO, Esperanza MALDONADO, Gustavo Chio CHO
Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 3, Pages 344-354 doi: 10.1007/s11709-011-0124-8
Keywords: modal analysis parameter identification ambient vibration test Eigensystem Realization Algorithm (ERA
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 502-508 doi: 10.1007/s11684-017-0590-z
Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitis B, long-term therapy has been recommended due to the high frequency of off-therapy viral DNA rebound and disease relapse. In this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the life cycle of HBV replication, and the potential significance of serum HBV RNA is systematically described. The production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBV RNA is found to be a suitable surrogate marker for the activity of intrahepatic covalently closed circular DNA (cccDNA), particularly among patients receiving NA therapy. Therefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBV RNA. In contrast to hepatitis B surface antigen (HBsAg) that can originate from either the cccDNA or the integrated HBV DNA fragment, serum HBV RNA, with pregenomic RNA origination, can only be transcribed from cccDNA. Therefore, the loss of serum HBV RNA would likely be a promising predicator for safe drug discontinuation. The clinical status of consistent loss of serum HBV RNA accompanied with low serum HBsAg levels might be implicated as a “para-functional cure,” a status nearly close to the functional cure of chronic hepatitis B, to distinguish the “functional cure” characterized as serum HBsAg loss with or without anti-HBs seroconversion.
Keywords: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
Special issue: Advancing supply chain resilience for excellence in the post-pandemic era
Frontiers of Engineering Management 2023, Volume 10, Issue 1, Pages 1-4 doi: 10.1007/s42524-022-0246-9
Frontiers of Engineering Management Pages 82-95 doi: 10.1007/s42524-022-0233-1
Keywords: pharmaceutical supply chain Internet of Things blockchain resilience post-pandemic era
Pyrolysis of WEEE plastics using catalysts produced from fly ash of coal gasification
Marika Benedetti, Lorenzo Cafiero, Doina De Angelis, Alessandro Dell’Era, Mauro Pasquali, Stefano Stendardo
Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 5, doi: 10.1007/s11783-017-0998-3
Keywords: Waste electrical and electronic equipment (WEEE) plastic mixture Pyrolysis Catalyst Fly ash Oil
Thoughts on China’s Integrated Circuit Chip Manufacturing in the Post-Moore Era
Hanming Wu, Feijun Zheng
Engineering 2023, Volume 23, Issue 4, Pages 33-39 doi: 10.1016/j.eng.2022.07.021
Networking Automation and Intelligence: A New Era of Network Innovation
Hongke Zhang, Wei Quan
Engineering 2022, Volume 17, Issue 10, Pages 13-16 doi: 10.1016/j.eng.2021.06.019
Title Author Date Type Operation
Wheat research and breeding in the new era of a high-quality reference genome
Rudi APPELS
Journal Article
Managing supply chain resilience in the era of VUCA
Ying GAO , Zhuo FENG , Shuibo ZHANG
Journal Article
Exploring the cancer genome in the era of next-generation sequencing
Hui Dong, Shengyue Wang
Journal Article
Servitization of manufacturing in the new ICTs era: A survey on operations management
Kangzhou WANG, Zhibin JIANG, Bo PENG, Hui JING
Journal Article
Ambient vibration testing and updating of the finite element model of a simply supported beam bridge
Ivan Gomez ARAUJO, Esperanza MALDONADO, Gustavo Chio CHO
Journal Article
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Journal Article
Special issue: Advancing supply chain resilience for excellence in the post-pandemic era
Journal Article
Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic era
Journal Article
Pyrolysis of WEEE plastics using catalysts produced from fly ash of coal gasification
Marika Benedetti, Lorenzo Cafiero, Doina De Angelis, Alessandro Dell’Era, Mauro Pasquali, Stefano Stendardo
Journal Article
Thoughts on China’s Integrated Circuit Chip Manufacturing in the Post-Moore Era
Hanming Wu, Feijun Zheng
Journal Article