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Therapeutic Characterization of 131I-Labeled Humanized Anti-B7-H3 Antibodies for Radioimmunotherapy Article

Fengqing Fu, Meng Zheng, Shandong Zhao, Yan Wang, Minzhou Huang, Hanqing Chen, Ziyi Huang, Kaijie Zhang, Liyan Miao, Xueguang Zhang

Engineering 2023, Volume 30, Issue 11,   Pages 190-202 doi: 10.1016/j.eng.2023.05.011

Abstract:

B7 homolog 3 (B7-H3) has attracted much attention in glioblastoma (GBM) radioimmunotherapy (RIT) dueIn this study, we report that two specific humanized anti-human B7-H3 antibodies (hu4G4 and hu4H12) derivedfrom mouse anti-human B7-H3 antibodies that were generated by computer-aided design and exclusivelyrecognize membrane expression of B7-H3 by human glioma cells.-H3 in situ glioma tumor models.

Keywords： B7-H3     Radioimmunotherapy     Glioblastoma     Pharmacokinetics     Pharmacodynamics    

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Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 8-20 doi: 10.1007/s11684-020-0739-z

Abstract: Since the first case of novel H7N9 infection was reported, China has experienced five epidemics of H7N9During the fifth wave, a highly pathogenic H7N9 strain emerged.Meanwhile, the H7N9 virus continues to accumulate mutations, and its affinity for the human respiratorycharacteristics of H7N9, the key gene mutations of the virus, and H7N9 vaccine, thus providing a scientificbasis for further monitoring and prevention of H7N9 influenza epidemics.

Keywords： H7N9     pandemic     epidemiology     mutations     vaccine     influenza    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract: Here we review what is known about the human humoral immune response to vaccination and infection with H7It seems that unlike vaccination with H5 hemagglutinin, which induces antibody responses mostly restrictedto the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses.

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 275-276 doi: 10.1007/s11684-013-0285-z

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The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 333-344 doi: 10.1007/s11684-013-0275-1

Abstract:

This study reports the first death caused by a novel avian influenza A (H7N9) virus in Zhejiang ProvinceThe patient had chronic hepatitis B and history of exposure to poultry.This H7N9 virus from Zhejiang is highly similar to isolates obtained from Shanghai, Jiangsu, Anhui, etctwo health workers presented with influenza-like symptoms, and they subsequently tested negative for H7N9possible high-risk factors for infections and death caused by the low-pathogenicity avian influenza A (H7N9

Keywords： avian influenza A (H7N9) virus     epidemiology     contacts     person-to-person transmission    

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Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 808-814 doi: 10.1007/s11684-021-0878-x

Abstract: families with EB, and eight variants including a novel nonsense variant (c.47G>A, p.W16*) in LAMA3A, p.G2366D; c.8569G>T, p.E2857*; c.3625_3635del, p.S1209fs) variants in COL7A1Notably, this study identified a nonsense variant in LAMA3 that causes EB within the Chinese populationand revealed that this variant resulted in a reduction in LAMA3 mRNA and protein expression levels

Keywords： epidermolysis bullosa     LAMA3     COL7A1     KRT5     Chinese families    

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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressorHowever, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7cMoreover, RGS16 was validated as a direct target gene of miR let-7c-5p.The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking downmiR let-7c-5p had the opposite effect.

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MSbetter selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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A 7-year follow-up study of the features and transformations of elderly male patients with OGTT-1h hyperglycemia

TIAN Hui, LI Chunlin, ZHONG Wenwen, PAN Changyu, LU Juming, CAO Xiutang

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 396-399 doi: 10.1007/s11684-008-0076-0

Abstract: glucose intake but with hyperglycemia (≥ 11.1 mmol/L) 1 hour after oral glucose tolerance test (OGTT-1hSeven years of follow-up visits were performed on 189 elderly male outpatients with OGTT-1h HG and dataFollow-up visits revealed that 19 patients with OGTT-1h HG were diagnosed with diabetes (10.1%), 78 patientsSynchronized comparison with IGT patients showed that the ratio of OGTT-1h HG patients turning to diabeteswas lower than that of IGT patients (21.1%, = 13.05, < 0.01), and the ratio of OGTT-1h HG patients

Keywords： special attention     prevalence     unchanged     dyslipidemia     elderly    

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Heat-spreading analysis of a heat sink base embedded with a heat pipe

B. V. BORGMEYER, H. B. MA,

Frontiers in Energy 2010, Volume 4, Issue 2,   Pages 143-148 doi: 10.1007/s11708-010-0013-1

Abstract: A simplified model predicting the heat transfer performance of a heat sink base with a high thermal conductivity was developed. Numerical analysis was performed using the commercial software FLUENT. The investigation indicates that for heat sink bases with a high effective thermal conductivity, such as the base embedded with a typical heat pipe, the entire heat sink can be modeled as a flat plate with a uniform temperature and an effective convection heat transfer coefficient. This simplified model can be used to determine the heat transfer performance of a heat sink embedded with a typical heat pipe or vapor chamber.

Keywords： heat pipe     heat sink     microprocessor heat removal    

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Mesenchymal Stem Cell Treatment for Acute Respiratory Distress Syndrome Induced by Epidemic Influenza A (H7N9 Article

Jiajia Chen, Chenxia Hu, Lijun Chen, Lingling Tang, Yixin Zhu, Xiaowei Xu, Lu Chen, Hainv Gao, Xiaoqing Lu, Liang Yu, Xiahong Dai, Charlie Xiang, Lanjuan Li

Engineering 2020, Volume 6, Issue 10,   Pages 1153-1161 doi: 10.1016/j.eng.2020.02.006

Abstract:

H7N9 viruses quickly spread between mammalian hosts and carry the risk of human-to-human transmissionrespiratory distress syndrome (ARDS), lung failure, and acute pneumonia are major lung diseases in H7N9stem cells (MSCs) is a promising choice for treating virus-induced pneumonia, and was used to treat H7N9The transplant of MSCs into patients with H7N9-induced ARDS was conducted at a single center throughincluded as a control group, while 17 patients with H7N9-induced ARDS acted as an experimental group

Keywords： H7N9     Mesenchymal stem cell     Epidemic Influenza A     Acute respiratory distress syndrome     COVID-19     Stem    

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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients throughimmunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis ofKnockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcomaIn vitro and in vivo studies also demonstrated that inhibiting by 3-MA inhibited cell growth

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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Catalytic ozonation of reactive red X-3B in aqueous solution under low pressure: decolorization and OH

Hong SUN,Min SUN,Yaobin ZHANG,Xie QUAN

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 4,   Pages 591-595 doi: 10.1007/s11783-014-0694-5

Abstract: Catalytic ozonation of Reactive Red X-3B in aqueous solution had been carried out in an ozone oxidationMn-Fe-ceramic honeycomb catalyst could obviously improve the decoloration efficiency of Reactive Red X-3BAdsorption of Reactive Red X-3B had no obviously influence on the degradation efficiency.significantly decreased the degradation efficiency, indicating that the degradation of Reactive Red X-3B

Keywords： catalytic ozonation     reactive red X-3B     ceramic honeycomb     hydroxyl radical (OH·)    

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Single and joint effects of HHCB and cadmium on zebrafish (

Lei ZHANG, Jing AN, Qixing ZHOU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 3,   Pages 360-372 doi: 10.1007/s11783-011-0353-z

Abstract: Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta-gammaresults indicated that the joint effect of HHCB and Cd changed during different exposure times within 120 h.

Keywords： 1     3     4     6     7     8-hexahydro-4     6     6     7     8     8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB)     cadmium (Cd)     antioxidant    

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Oxidative leaching kinetics of molybdenum-uranium ore in H

El-Ahmady, H. B. Hassib, A. S. Helal

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 95-102 doi: 10.1007/s11705-013-1317-6

Abstract: The optimum process operating parameters were: temperature: 95°C; H O concentration: 0.5 M; sulfuricacid concentration: 2.5 M; time: 2 h; particle size: 74 μm, liquid-to-solid ratio: 14 ∶ 1 and agitationThe temperature, concentrations of H O and H SO and the mesh size are the main factors that influenceThe reaction order in H SO was 1.0012 and in H O it was 1.2544.

Keywords： leaching of molybdenum     leaching of uranium     kinetics    

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Title Author Date Type Operation

Therapeutic Characterization of 131I-Labeled Humanized Anti-B7-H3 Antibodies for Radioimmunotherapy

Fengqing Fu, Meng Zheng, Shandong Zhao, Yan Wang, Minzhou Huang, Hanqing Chen, Ziyi Huang, Kaijie Zhang, Liyan Miao, Xueguang Zhang

Journal Article

Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Journal Article

The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Journal Article

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

A 7-year follow-up study of the features and transformations of elderly male patients with OGTT-1h hyperglycemia

TIAN Hui, LI Chunlin, ZHONG Wenwen, PAN Changyu, LU Juming, CAO Xiutang

Journal Article

Heat-spreading analysis of a heat sink base embedded with a heat pipe

B. V. BORGMEYER, H. B. MA,

Journal Article

Mesenchymal Stem Cell Treatment for Acute Respiratory Distress Syndrome Induced by Epidemic Influenza A (H7N9

Jiajia Chen, Chenxia Hu, Lijun Chen, Lingling Tang, Yixin Zhu, Xiaowei Xu, Lu Chen, Hainv Gao, Xiaoqing Lu, Liang Yu, Xiahong Dai, Charlie Xiang, Lanjuan Li

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

Catalytic ozonation of reactive red X-3B in aqueous solution under low pressure: decolorization and OH

Hong SUN,Min SUN,Yaobin ZHANG,Xie QUAN

Journal Article

Single and joint effects of HHCB and cadmium on zebrafish (

Lei ZHANG, Jing AN, Qixing ZHOU

Journal Article

Oxidative leaching kinetics of molybdenum-uranium ore in H

El-Ahmady, H. B. Hassib, A. S. Helal

Journal Article