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Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 475-479 doi: 10.1007/s11684-009-0086-6

Abstract: The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factor-κB (NF-κB) in the colonic mucosa of patients with ulcerative colitis (UC) was examined. Real-time polymerase chain reaction and immunohistochemistry were used to detect the expression of STAT6 and NF-κB p65 at both mRNA and protein levels in the colonic mucosa of patients with UC and healthy volunteers. The results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patients with UC were significantly higher than in normal controls at both mRNA and protein levels. These data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of UC and underscore the potential value of anti-UC strategies in the clinical management of this disease.

Keywords： ulcerative colitis signal transducer and activator of transcription 6 (STAT6) nuclear factor-κ B p65 (NF-κ B p65)

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Experimental study on the establishment and maintenance of brain death model with pigs

ZHANG Shuijun, SHI Jihua, ZHAI Wenlong, SONG Yan, CHEN Shi

Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 161-166 doi: 10.1007/s11684-007-0030-6

Abstract: This study sought to explore methods of establishing a stable brain death (BD) model using Bama miniSixteen anesthetized Bama mini pigs were randomized into a control group ( = 5) and a BD group ( = 11Intracranial pressure (ICP) was increased in a modified, slow, and intermittent way to establish BD.Prior to BD being established, a tic reaction inevitably occurred.We used an improved method of increasing ICP to establish a stable BD model.

Keywords： BD control Hemodynamic cardiopulmonary modified