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Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats
Qihui Luo,Zhengli Chen,Anchun Cheng,Mingshu Wang,Jing Fang,Xi Peng,Li Tang
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 82-89 doi: 10.1007/s11684-015-0376-0
Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent.The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts,and teratogenicity were studied in pregnant Sprague-Dawley rats after intragastric administration of MetacavirNo Metacavir-associated pathological changes were observed.., 40 times the effective dose in rats), Metacavir shows some maternal toxicity to SD rats.
Keywords： deoxyguanosine analogue Metacavir pregnancy maternal toxicity embryo toxicity teratogenicity
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