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The role of microRNAs in adipocyte differentiation

Rong Zhang, Di Wang, Zhuying Xia, Chao Chen, Peng Cheng, Hui Xie, Xianghang Luo

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 223-230 doi: 10.1007/s11684-013-0252-8

Abstract: In this review, we summarize the biology and functional mechanisms of miRNAs in adipocyte differentiation

Keywords： microRNA adipocyte differentiation adipogenesis

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Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 162-172 doi: 10.1007/s11684-015-0382-2

Abstract:

Adipose tissue is an important organ for energy homeostasis. White adipose tissue stores energy in the form of triglycerides, whereas brown adipocytes and recently identified beige adipocytes are specialized in dissipating energy by thermogenesis or contribution to dispose glucose and clear triglycerides in blood. The inverse correlation between the brown adipose tissue activity and body mass suggests its protective role against body fat accumulation. Thus, recruitment and activation of brown or beige adipose tissue become particularly appealing targets for increasing energy expenditure. Angiogenesis and sympathetic nerve signals are the fundamental determinants for brown and beige adipose tissue development, as well as for their metabolic functions. Secretary factors including BMPs can induce the development, the activation of brown or beige adipose tissue, which seem to be promising for therapeutic development.

Keywords： brown adipocyte beige adipocyte metabolism obesity

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Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia

Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee

Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 130-138 doi: 10.1007/s11684-017-0555-2

Abstract:

Brown adipose tissue (BAT) plays a fundamental role in maintaining body temperature by producing heat. BAT that had been know to exist only in mammals and the human neonate has received great attention for the treatment of obesity and diabetes due to its important function in energy metabolism, ever since it is recently reported that human adults have functional BAT. In addition, beige adipocytes, brown adipocytes in white adipose tissue (WAT), have also been shown to take part in whole body metabolism. Multiple lines of evidence demonstrated that transplantation or activation of BAT or/and beige adipocytes reversed obesity and improved insulin sensitivity. Furthermore, many genes involved in BAT activation and/or the recruitment of beige cells have been found, thereby providing new promising strategies for future clinical application of BAT activation to treat obesity and metabolic diseases. This review focuses on recent advances of BAT function in the metabolic aspect and the relationship between BAT and cancer cachexia, a pathological process accompanied with decreased body weight and increased energy expenditure in cancer patients. The underlying possible mechanisms to reduce BAT mass and its activity in the elderly are also discussed.

Keywords： brown adipose tissue beige adipocyte anti-obesity anti-diabetes cancer cachexia aging

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Hydrogen Sulfide Promotes Adipocyte Differentiation, Hyperplasia, and Hypertrophy Article

Richa Verma,Ming Fu,Guangdong Yang,Lingyun Wu,Rui Wang

Engineering 2023, Volume 20, Issue 1, Pages 36-48 doi: 10.1016/j.eng.2022.09.010

Abstract: glucose/insulin incubation, H₂S further stimulated glucose consumption and deteriorated adipocyteIn conclusion, H₂S increases adipocyte differentiation, hypertrophy, and hyperplasia, implying

Keywords： Adipogenesis Adipocytes Gasotransmitter Glucose H₂S Insulin Lipid Obesity