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2016 1

2012 1

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ASIC3 1

C-fiber reflex 1

TRPV1 1

analgesia 1

continual reassessment method 1

electroacupuncture 1

infants 1

minimum effective dose 1

postoperative analgesia 1

tramadol 1

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Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the

Yue’e Dai, Dongxu Lei, Zhenghua Huang, Yan Yin, G. Allen Finley, Yunxia Zuo

Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 288-295 doi: 10.1007/s11684-012-0208-4

Abstract: However, the analgesia efficacy of tramadol, particularly its minimum effective dose (MED), is not clearThe aim of this study is to find MED of tramadol for postoperative analgesia in infants.The successful analgesia probability of tramadol 0.4 mg?kg^-1?In phase 3, the successful analgesia probability for dose 0.35 mg?kg^-1?/sup>was 96.7% (95% CI, 0.853–0.997).We have demonstrated that tramadol provides insufficient analgesia

Keywords： tramadol minimum effective dose postoperative analgesia infants continual reassessment method

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Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia

Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 465-472 doi: 10.1007/s11684-016-0482-7

Abstract: studies have demonstrated the effects of different afferent fibers on electroacupuncture (EA)-induced analgesiaHowever, contributions of functional receptors expressed on afferent fibers to the EA analgesia remainand transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemic analgesiaThus, segmental analgesia of EA with lower intensity is partially mediated by ASIC3 receptor on Aβ-fiber, whereas systemic analgesia induced by EA with higher intensity is more likely induced by TRPV1

Keywords： electroacupuncture analgesia ASIC3 TRPV1 C-fiber reflex