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Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou
Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 411-415 doi: 10.1007/s11684-012-0226-2
Ketamine exerts rapid and robust antidepressant properties in both animal models and depressed patientsand tramadol possesses potential antidepressant effects.We hypothesized that tramadol pretreatment might reinforce ketamine-elicited antidepressant effects withResults showed that tramadol (5 mg/kg) administrated alone neither elicited antidepressant effects norIn conclusion, tramadol pretreatment reinforces the ketamine-elicited antidepressant effects, which is
Keywords： tramadol ketamine antidepressant brain-derived neurotrophic factor tropomyosin-related kinase B
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