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Immunosuppression and Liver Transplantation Review
Jan Lerut, Samuele Iesari
Engineering 2023, Volume 21, Issue 2, Pages 175-187 doi: 10.1016/j.eng.2022.07.007
Perfect surgical techniques and adequate immunosuppression are key toconsiderable and conceptually diverse study designs have failed to afford a clear definition of the optimal immunosuppressionand short-term steroids—beyond possible induction—remains the currently accepted standard immunosuppressionof rejection, customization of the immunosuppressive load, and long-term side effects due to chronic immunosuppressionBoth elements are critical to progress toward more prudent immunosuppression handling and favor clinical
Keywords: Liver transplantation Immunosuppression Rejection Tolerance Clinical trial
Farhad Sahebjam,John M. Vierling
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 187-219 doi: 10.1007/s11684-015-0386-y
Keywords: autoimmune hepatitis autoantibodies diagnosis immunological diseases drug-induced liver injury therapy immunosuppression
Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa
Engineering 2022, Volume 10, Issue 3, Pages 30-43 doi: 10.1016/j.eng.2021.10.018
Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that have revolutionized the field of adoptive cellular therapy (ACT). Cells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific binding region within the synthetic CAR construct. The advantage of cells with programmed specificity has been demonstrated clinically in the field of oncology, and it is clear that such cells have greater accuracy, potency, and reduced off-target therapeutic effects compared with their unmodified counterparts. In contrast to conventional T cells (Tconvs), regulatory T cells (Tregs) play a major role in suppressing immune activation and regulating the host immune response. CAR expression within Tregs has been proposed as a therapy for autoimmune and inflammatory diseases, graft-versus-host disease (GvHD), and organ transplant rejection. In the latter, they hold immense potential as mediators of immune tolerance for recipients of allotransplants. However, current research into CAR-Treg engineering is extremely limited, and there is uncertainty regarding optimal design for therapeutic use. This review examines the rationale behind the development of CAR-Tregs, their significance for human transplantation, potential designs, safety considerations, and comparisons of CAR-Tregs in transplantation models to date.
Keywords: Chimeric antigen receptors T cell Treg Alloimmunity Bioengineering Transplant Autoimmunity
Importance of Viral Disease in Dairy Cow Fertility Review
D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng
Engineering 2020, Volume 6, Issue 1, Pages 26-33 doi: 10.1016/j.eng.2019.07.020
Keywords: diarrhea virus Bovine herpesvirus-1 Bovine herpesvirus-4 Schmallenberg virus Bluetongue virus Immunosuppression
Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi
Engineering 2022, Volume 10, Issue 3, Pages 65-73 doi: 10.1016/j.eng.2022.02.001
Keywords: Cynomolgus monkey Pig Kidney Fetal kidney Immunosuppression
Title Author Date Type Operation
Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in
Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa
Journal Article
Importance of Viral Disease in Dairy Cow Fertility
D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng
Journal Article
In Vivo Development of Fetal Pig Kidneys in Mature Monkeys Under Clinically Approved Immunosuppressant Drugs
Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi
Journal Article
Han Jun: Interpretation of the Frontier Progress of Immunosuppression and Escape Mechanism of Important
22 Dec 2022
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