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2021 1

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ferroptosis 1

lung cancer 1

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: In this study, we tested the anticancer activity of orlistat, an FDA-approved anti-obesity drug, in humanand mouse cancer cells in vitro and in vivo, and we found that orlistat, as a single agentMechanistically, we found that orlistat reduced the expression of GPX4, a central ferroptosis regulatorMoreover, in a mouse xenograft model, orlistat significantly inhibited tumor growth and reduced the tumorOur study showed a novel mechanism of the anticancer activity of orlistat and provided the rationale

Keywords： orlistat     ferroptosis     FAF2     lung cancer    

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Journal Article