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Journal Article 3

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2008 2

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BGB-A445 1

OX40 1

OX40L noncompetitive 1

adsorbent 1

adsorption proportion 1

agonistic antibody 1

dendrimer polyamidoamine 1

dose-dependent 1

generation 1

inflammatory 1

interleukin-10 1

ox-LDL 1

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: The cells were further stimulated by ox-LDL, ox-LDL plus LPS, ox-LDL plus IL-10 and LPS.foam cell formation was increased from (9.77 ± 1.70)% to (16.27 ± 2.27)% after 24 h stimulation with ox-LDLThese results indicated that IL-10 can effectively prevent the formation of foam cells induced by ox-LDLThis study demonstrates that ox-LDL can cause foam cell formation from macrophages .IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.

Keywords： inflammatory presence interleukin-10 dose-dependent ox-LDL

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: OX40 is a costimulatory receptor that is expressed primarily on activated CD4⁺, CD8^{+OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activationTherefore, the use of agonistic anti-OX40 antibodies for cancer immunotherapy has gained great interestHowever, most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limitedTaken together, our findings show that BGB-A445, which does not block OX40–OX40L interaction in contrast}

Keywords： BGB-A445 OX40 agonistic antibody OX40L noncompetitive