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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: In this study, we identified the correlation between p53 functional activation and its genotype in fiveTo examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayFurther, the expression of p53 protein and four transcripts of well-known p53 target genes were investigatedThe results showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could beTo judge p53 function in a particular cell line, it is important to examine the p53 functional activation

Keywords: p53     esophageal squamous cell carcinoma     DNA damage    

Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 1-15 doi: 10.1007/s11705-016-1562-6

Abstract: successfully demonstrated that these makaluvamines attack several key molecular targets, including the MDM2-p53

Keywords: synthesis     marine drugs     tricyclic pyrroloquinone alkaloid     cancer therapy     MDM2     p53    

Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 41-44 doi: 10.1007/s11684-009-0009-6

Abstract: non-small cell lung cancer (NSCLC) and the relationship between Syk and clinicopathologic factors and p53Immunohistochemistry was applied to detect the expression of Syk and p53 protein in 39 cases of NSCLCThe Syk expression was positively correlated withthe p53 expression in NSCLC specimens ( = 0.025).

Keywords: Syk kinase     carcinoma     non-small-cell lung     tumor suppressor protein p53    

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved.Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53Among the 9 trialed patients with available TP53 sequencing results, the 6 patients with p53 mutationsIn a mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher

Keywords: p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

Frontiers in Energy 2023, Volume 17, Issue 2,   Pages 189-197 doi: 10.1007/s11708-023-0873-9

Abstract: Peer-to-peer (P2P) energy trading is an emerging energy supply paradigm where customers with distributedP2P energy trading can facilitate local power and energy balance, thus being a potential way to manageIt is of great importance to explore P2P energy trading via public power networks, to which most DERsIn this paper, the practical challenges of conducting P2P energy trading via public power networks areFinally, the way forward for facilitating P2P energy trading via public power networks is proposed.

Keywords: distribution network     local virtual private network     network charges     peer-to-peer (P2P) energy trading    

Solomon P Wasser: medicinal use of mushroom (2019-9-19)

Solomon P Wasser(高级职称)

20 Jan 2021

Keywords: 农业科学    

An Interactive ServiceorientedP2P Networks Architecture Reference Model

Liu Ye,Liu Linfen,Zhuang Yanyan

Strategic Study of CAE 2007, Volume 9, Issue 9,   Pages 72-77

Abstract: <p style="text-align: justify;">An interactive service- oriented P2P networks architecture (ISPNA) is Based on the further analysis on the service demand of distributed P2P applications,  andconsidering the characteristics of P2P networks such as loose-coupled,  self-organizing,  andscalability,  the key availability enhancing issues of P2P networks are resolved by several differentp>

Keywords: P2P networks     architecture     reference model     resource     service    

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 123-138 doi: 10.1007/s11705-022-2194-7

Abstract: The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues.NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers.Because it is a quinone reductase, many bioimaging probes based on quinone structures target NAD(P)H:fluorescent, near-infrared and two-photon fluorescent probes, as well as nanosystems for delivering the NAD(P)valuable information for the future development of probes and nano-delivery systems that target NAD(P)

Keywords: NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 5,   Pages 391-403 doi: 10.1631/FITEE.1400267

Abstract: The continuous emerging of peer-to-peer (P2P) applications enriches resource sharing by networks, butTherefore, P2P applications monitoring, in particular, P2P traffic classification, is becoming increasinglyIn this paper, we propose a novel approach for accurate P2P traffic classification at a fine-grainedsome special flows that are appearing frequently and steadily in the traffic generated by specific P2PExperimental results show that P2P applications can be classified with a true positive rate higher than

Keywords: Traffic classification     Peer-to-peer (P2P)     Fine-grained     Host-based    

Application research of Q&P concept in hot rolled AHSS production

Yuan Guo,Kang Jian,Zhang He,Li Yunjie,Hu Hongling and Wang Guodong

Strategic Study of CAE 2014, Volume 16, Issue 1,   Pages 59-65

Abstract: <p>In order to satisfy the requirements of lightweight in the automotive industry,the development ofadvanced high strength steel obtained using the quenching and partitioning (Q&P)process has beenof Q&P process on the conventional hot rolling production line.The feasibility of producing the hot rolled Q&P steel(DQ(direct quenching)&P steel)was determinedp>

Keywords: advanced high strength steel     Q&P     DQ&P     hot rolling     retained austenite    

UV-LED/P25-based photocatalysis for effective degradation of isothiazolone biocide

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1379-x

Abstract: <p>• UV-LED with shorter wavelength was beneficial for photocatalytic degradation

Keywords: Degradation     Photocatalytic     LED     CMIT     P25    

Comparison of modeling methods for wind power prediction: a critical study

Rashmi P. SHETTY, A. SATHYABHAMA, P. Srinivasa PAI

Frontiers in Energy 2020, Volume 14, Issue 2,   Pages 347-358 doi: 10.1007/s11708-018-0553-3

Abstract: Prediction of power generation of a wind turbine is crucial, which calls for accurate and reliable models. In this work, six different models have been developed based on wind power equation, concept of power curve, response surface methodology (RSM) and artificial neural network (ANN), and the results have been compared. To develop the models based on the concept of power curve, the manufacturer’s power curve, and to develop RSM as well as ANN models, the data collected from supervisory control and data acquisition (SCADA) of a 1.5 MW turbine have been used. In addition to wind speed, the air density, blade pitch angle, rotor speed and wind direction have been considered as input variables for RSM and ANN models. Proper selection of input variables and capability of ANN to map input-output relationships have resulted in an accurate model for wind power prediction in comparison to other methods.

Keywords: power curve     method of least squares     cubic spline interpolation     response surface methodology     artificial neural network (ANN)    

noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related

Keywords: ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

The Generating Lock P<G,X,X'>and Its Central Encrypting System

Shi Kaiquan,Chen Zexiong

Strategic Study of CAE 2000, Volume 2, Issue 2,   Pages 41-46

Abstract: <p>The conception of the generating lock  P <G ,X, X´> and the centralencrypting system composed of P<G ,X, X´>with data generating technologyThese systems include the generating lock P<G ,X, X´> and single-tooth central encryptingsub>A≠XB , respectively and complete their secret communication with P<p>

Keywords: the generating lock     the central encrypting system     multi-tooth encrypting-decrypting algorithm     P    X     X    

Title Author Date Type Operation

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

Journal Article

Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

construction integration technology in Brazil’s superlarge deep-water offshore oil and gas unit project (FPSO P67/P70)

Journal Article

P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

Journal Article

Solomon P Wasser: medicinal use of mushroom (2019-9-19)

Solomon P Wasser(高级职称)

20 Jan 2021

Conference Videos

An Interactive ServiceorientedP2P Networks Architecture Reference Model

Liu Ye,Liu Linfen,Zhuang Yanyan

Journal Article

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Journal Article

Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

Journal Article

Application research of Q&P concept in hot rolled AHSS production

Yuan Guo,Kang Jian,Zhang He,Li Yunjie,Hu Hongling and Wang Guodong

Journal Article

UV-LED/P25-based photocatalysis for effective degradation of isothiazolone biocide

Journal Article

Comparison of modeling methods for wind power prediction: a critical study

Rashmi P. SHETTY, A. SATHYABHAMA, P. Srinivasa PAI

Journal Article

noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/

Journal Article

The Generating Lock P<G,X,X'>and Its Central Encrypting System

Shi Kaiquan,Chen Zexiong

Journal Article