Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 3

Year

2023 1

2022 1

2021 1

Keywords

COVID-19 1

ZIKV inhibitors 1

Zika virus 1

antivirals 1

artemisinin 1

cancer 1

clinical drugs 1

drug repurposing 1

inflammation 1

repurposing 1

traditional Chinese medicine 1

open ︾

Search scope:

排序： Display mode:

Discovery and repurposing of artemisinin

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 1-9 doi: 10.1007/s11684-021-0898-6

Abstract: Malaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigm shift and been recognized as the “best hope for the treatment of malaria” by World Health Organization. With its high potency and low toxicity, the wide use of artemisinin effectively treats the otherwise drug-resistant parasites and helps many countries, including China, to eventually eradicate malaria. Here, we will first review the initial discovery of artemisinin, an extraordinary journey that was in stark contrast with many drugs in western medicine. We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer, inflammation, immunoregulation-related diseases, and COVID-19. Finally, we will discuss the implications of the “artemisinin story” and how that can better guide the development of TCM today. We believe that artemisinin is just a starting point and TCM will play an even bigger role in healthcare in the 21st century.

Keywords： artemisinin drug repurposing cancer inflammation COVID-19 traditional Chinese medicine

HTML PDF Collect

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Repurposing clinically approved drugs could be an effective approach to quickly respond to an emergencyThis review focuses on the recent research and development of agents against ZIKV infection by repurposing

Keywords： Zika virus clinical drugs ZIKV inhibitors antivirals repurposing