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2016 1

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CD176 1

Thomsen-Friedenreich antigen 1

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cancer 1

metastasis 1

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells and hepatocytes

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: A positive clone of CD176 single-chain variable antibody fragment (scFv) was successfully screened fromThe CD176 scFv was expressed in Escherichia coli and purified.The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells.Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelialThis CD176 scFv provides a basis for future development of recombinant CD176-specific antibodies that

Keywords： CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells and hepatocytes

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article