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GBC-SD 1

Survivin-1 1

chemotherapy 1

colorectal carcinoma 1

control 1

influence 1

sensibility 1

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survivin 1

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Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 304-307 doi: 10.1007/s11684-007-0058-7

Abstract: The transient transfection of survivin-targeted siRNA to Lovo cells and its influence on the biologicalTwo pairs of 19 base pairs (bp) siRNA-specific targeted survivin gene were designed and synthesized bytranscription (Survivin-1, Survivin-2).We found that the expression levels of survivin mRNA of the two RNAi groups (Survivin-1 group and Survivinthe expression of survivin mRNA, inhibited cell growth and induce cell apoptosis.

Keywords： control therapy influence Survivin-1 colorectal carcinoma

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Effect of pEGFP-survivin on GBC-SD cell growth and chemotherapy sensitivity

Hanbin SHEN MD, Bin ZHANG MBA, Song ZHAO BM, Qichang ZHENG MD, Jianping GONG MD, Xiaotang CAI BM,

Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 485-490 doi: 10.1007/s11684-009-0089-3

Abstract: This paper is aimed to investigate the effect of survivin shRNA on chemotherapy resistance in human gallbladderof human gallbladder carcinoma GBC-SD, GBC-SD/enhanced green fluorescent protein (EGFP), and GBC-SD/survivinCell viability was decreased significantly in GBC-SD/survivin cells, and survivin expression was decreasedsignificantly (mRNA and protein of survivin were decreased by 74.7% and 71.5%, respectively).The survivin shRNA could down-regulate the expression of survivin in GBC-SD cells significantly and improve

Keywords： survivin shRNA chemotherapy sensibility GBC-SD