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Discovery and repurposing of artemisinin

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 1-9 doi: 10.1007/s11684-021-0898-6

Abstract: The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigmWith its high potency and low toxicity, the wide use of artemisinin effectively treats the otherwiseHere, we will first review the initial discovery of artemisinin, an extraordinary journey that was inFinally, we will discuss the implications of the “artemisinin story” and how that can better guide theWe believe that artemisinin is just a starting point and TCM will play an even bigger role in healthcare

Keywords： artemisinin     drug repurposing     cancer     inflammation     COVID-19     traditional Chinese medicine    

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Purification of artemisinin from quercetin by anti-solvent crystallization

Chandrakant R. MALWADE, Haiyan QU, Ben-Guang RONG, Lars P. CHRISTENSEN

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 72-78 doi: 10.1007/s11705-013-1305-x

Abstract: In the present work, anti-solvent crystallization of artemisinin from four different organic solventsThe effect of an impurity (quercetin) on the performance of anti-solvent crystallization of artemisininThe fundamental process data such as solubility of artemisinin in pure organic solvents and their binaryFirstly, the anti-solvent crystallization of artemisinin without impurity was performed from all fourHowever, the purity of artemisinin crystals were reduced when quercetin concentration was 50% of its

Keywords： anti-solvent crystallization     artemisinin     quercetin     solubility     Artemisia annua    

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Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine Review

Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yujie Li, Fulong Liao, Tingliang Jiang,Youyou Tu

Engineering 2019, Volume 5, Issue 1,   Pages 32-39 doi: 10.1016/j.eng.2018.11.011

Abstract:

Artemisinin and its derivatives represent the most important and influential class of drugs in theSince the discovery of artemisinin in the early 1970s, the global community has made great strides inToday, even as artemisinin continues to serve as the foundation for antimalarial therapy, numerous challengesHere, we provide an overview of the story of artemisinin in terms of its past, present, and future.

Keywords： Artemisinin     Mechanism of action     Malaria     Anti-cancer    

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Profiling the Antimalarial Mechanism of Artemisinin by Identifying Crucial Target Proteins Article

Peng Gao, Jianyou Wang, Jiayun Chen, Liwei Gu, Chen Wang, Liting Xu, Yin Kwan Wong, Huimin Zhang, Chengchao Xu, Lingyun Dai, Jigang Wang

Engineering 2023, Volume 31, Issue 12,   Pages 86-97 doi: 10.1016/j.eng.2023.06.001

Abstract:

The widespread use of artemisinin (ART) and its derivatives has significantly reduced the global burden

Keywords： Artemisinin     Antimalaria     Target identification     MS-CETSA     Transcriptomics    

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Title Author Date Type Operation

Discovery and repurposing of artemisinin

Journal Article

Purification of artemisinin from quercetin by anti-solvent crystallization

Chandrakant R. MALWADE, Haiyan QU, Ben-Guang RONG, Lars P. CHRISTENSEN

Journal Article

Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine

Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yujie Li, Fulong Liao, Tingliang Jiang,Youyou Tu

Journal Article

Profiling the Antimalarial Mechanism of Artemisinin by Identifying Crucial Target Proteins

Peng Gao, Jianyou Wang, Jiayun Chen, Liwei Gu, Chen Wang, Liting Xu, Yin Kwan Wong, Huimin Zhang, Chengchao Xu, Lingyun Dai, Jigang Wang

Journal Article