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Molecular aspects of MERS-CoV

Ali A. Rabaan, Ali M. Bazzi, Shamsah H. Al-Ahmed, Jaffar A. Al-Tawfiq

Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 365-377 doi: 10.1007/s11684-017-0521-z

Abstract:

Middle East respiratory syndrome coronavirus (MERS-CoV) is a betacoronavirus which can cause acuteMERS-CoV ancestors may be found in Old World bats of the Vespertilionidae family.After a proposed bat to camel switching event, transmission of MERS-CoV to humans is likely to have beenbroad-spectrum antiviral nitazoxanide has been shown to have in vitro activity against MERS-CoVGLS-5300, a prophylactic DNA-plasmid vaccine encoding S protein, is the first MERS-CoV vaccine to be

Keywords： MERS-CoV Saudi Arabia spike protein transmission evolution vaccine

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From SARS to MERS: evidence and speculation

Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 377-382 doi: 10.1007/s11684-016-0466-7

Abstract:

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen.In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patientsWithout a travel history, few clinical and radiological features can reliably differentiate MERS fromBut in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severeIn this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology

Keywords： middle east respiratory syndrome animal origin cross-species transmission monoclonal antibody

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Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins Review

Yan-Hua Li, Chen-Yu Hu, Nan-Ping Wu, Hang-Ping Yao, Lan-Juan Li

Engineering 2019, Volume 5, Issue 5, Pages 940-947 doi: 10.1016/j.eng.2018.11.035

Abstract:

Middle East respiratory syndrome (MERS) is a viral respiratory disease caused by a de novo coronavirus—Middle East respiratory syndrome coronavirus (MERS-CoV)—that is associatedHowever, the mechanism by which MERS-CoV infects humans remains unclear.For this purpose, detailed information on MERS-CoV proteins is needed.different potential strategies for limiting the outbreak of MERS-CoV.

Keywords： MERS-CoV Spike protein Structural protein Accessory protein Nonstructural protein

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Middle East respiratory syndrome coronavirus: a comprehensive review

Mahmoud M. Shehata,Mokhtar R. Gomaa,Mohamed A. Ali,Ghazi Kayali

Frontiers of Medicine 2016, Volume 10, Issue 2, Pages 120-136 doi: 10.1007/s11684-016-0430-6

Abstract:

The Middle East respiratory syndrome coronavirus was first identified in 2012 and has since then remained uncontrolled. Cases have been mostly reported in the Middle East, however travel-associated cases and outbreaks have also occurred. Nosocomial and zoonotic transmission of the virus appear to be the most important routes. The infection is severe and highly fatal thus necessitating rapid and efficacious interventions. Here, we performed a comprehensive review of published literature and summarized the epidemiology of the virus. In addition, we summarized the virological aspects of the infection and reviewed the animal models used as well as vaccination and antiviral tested against it.

Keywords： MERS coronavirus review

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Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

Jaffar A. Al-Tawfiq,Ali S. Omrani,Ziad A. Memish

Frontiers of Medicine 2016, Volume 10, Issue 2, Pages 111-119 doi: 10.1007/s11684-016-0446-y

Abstract:

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memoriesMore than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%.No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia inMost MERS-CoV cases were secondary to large outbreaks in healthcare settings.Travel-associated MERS infection remains low.

Keywords： coronavirus MERS Middle East respiratory syndrome

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Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 462-470 doi: 10.1007/s11684-017-0596-6

Abstract: severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoVWe also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola

Keywords： human monoclonal antibodies emerging infectious diseases SARS-CoV MERS-CoV Ebola virus

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Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia

Sarah H. Alfaraj, Jaffar A. Al-Tawfiq, Talal A. Altuwaijri, Ziad A. Memish

Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 126-130 doi: 10.1007/s11684-017-0603-y

Abstract: Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an importantA review of studies conducted from June 2012 to April 19, 2016 reported 31 pediatric MERS-CoV cases.In this paper, we present the clinical and laboratory features of seven patients with pediatric MERS.other patients (43%) were asymptomatic and were in contact with patients with confirmed diagnosis of MERS-CoVThe documented MERS-CoV Ct values were 32–38 for four of the seven cases.

Keywords： Middle East respiratory syndrome coronavirus MERS-CoV pregnancy pediatrics