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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associatedIn this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patientsusing polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP).Survival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-MeierWe found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 437-442 doi: 10.1007/s11684-009-0074-x

Abstract: Rs5065 NPPA gene polymorphism leads to the translation of NPPA with two additional arginines and hasThe purpose of the present study was to investigate the relationship between the rs5065 NPPA gene polymorphismWe genotyped the single nucleotide polymorphism (SNP) rs5065 NPPA in the human NPPA gene in 1861 sex-Our results suggest that the C allele of rs5065 NPPA gene polymorphism may be associated with the risk

Keywords： natriuretic peptide precursor A     coronary heart disease     gene polymorphism     allelic discrimination     polymorphism    

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Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 37-44 doi: 10.1007/s11705-009-0294-2

Abstract: Polymorphism is a widespread phenomenon observed in more than half of all drug substances.

Keywords： development     Polymorphism     elucidation     controversial     relationship    

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Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 101-105 doi: 10.1007/s11684-010-0017-6

Abstract: This study aims to investigate the genetic association between the polymorphism of cytosolic phospholipase

Keywords： schizophrenia     cytosolic phospholipase A2     ligase detection reaction     polymorphism    

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Polymorphism and crystal transformation of penicillin sulfoxide

Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 4,   Pages 442-447 doi: 10.1007/s11705-011-1140-x

Abstract: Penicillin sulfoxide is the intermediate for the synthesis of 7-amino-3-desacetoxycephalosporanic acid which is one of the most important nucleuses of cephalosporin antibiotic. In this contribution, two crystal structures of penicillin sulfoxide (forms I and II) were determined by X-ray diffraction, and their thermotropic properties were investigated by differential scanning calorimetry (DSC). Furthermore, the transformation of form II to form I was studied quantitatively by Raman spectroscopy, and its rates at different temperatures were determined. The results indicate that penicillin sulfoxide is more stable as form I, and the temperature plays an important role in the crystal transformation.

Keywords： penicillin sulfoxide     crystallization     polymorphism     crystal transformation     Raman spectroscopy    

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Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile

TANG Zhongzhi, LI Junyao, YANG Jianhong

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 178-181 doi: 10.1007/s11684-008-0033-y

Abstract: To study the relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and bloodBy using PCR-RFLP, the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertensionThe distribution of eNOS Glu298Asp polymorphism had no significant difference between different bloodrisk of hypertension in individuals with serum TC above 5.4 mmol/L ( = 0.03, = 2.65). eNOS Glu298Asp polymorphism
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Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 230-233 doi: 10.1007/s11684-007-0045-z

Abstract: The relationship between the tenth exon C825T of G-protein β3 subunit (GNB) genetic polymorphism andPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotypeGNB C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects.No evidence was found to suggest an association between GNB C825T polymorphism and hypertension in the

Keywords： case-control     significant difference     reaction-restriction fragment     C825T polymorphism     evidence    

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Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 320-326 doi: 10.1007/s11684-007-0062-y

Abstract: The aim of this study was to explore the association of the genetic polymorphism of and with the susceptibilityIt was also found that there were potential interactions between alcohol consumption and the polymorphismThe genetic polymorphism in may be associated with the risk of CBP in the Chinese occupational populationand further research is needed for the association between the genetic polymorphism in and the susceptibility

Keywords： case-control     rs2854451     regression analysis     haplotype     further research    

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community structure in different wastewater treatment processes characterized by single-strand conformation polymorphism

ZHAO Yangguo, WANG Aijie, REN Nanqi, ZHAO Yan

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 1,   Pages 116-121 doi: 10.1007/s11783-008-0018-8

Abstract: cesses were studied by a culture-independent genetic fingerprinting technique single-strand conformation polymorphism

Keywords： technique single-strand     proportion     bioreactor     community diversity     fingerprinting technique    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract:

This study was designed to investigate the contribution of miRNA-122-binding site polymorphism at

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (HBV) mutations    

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract:

In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic polymorphism    

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Current molecular biologic techniques for characterizing environmental microbial community

Dawen GAO, Yu TAO

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 1,   Pages 82-97 doi: 10.1007/s11783-011-0306-6

Abstract: Microbes are vital to the earth because of their enormous numbers and instinct function maintaining the natural balance. Since the microbiology was applied in environmental science and engineering more than a century ago, researchers desire for more and more information concerning the microbial spatio-temporal variations in almost every fields from contaminated soil to wastewater treatment plant (WWTP). For the past 30 years, molecular biologic techniques explored for environmental microbial community (EMC) have spanned a broad range of approaches to facilitate the researches with the assistance of computer science: faster, more accurate and more sensitive. In this feature article, we outlined several current and emerging molecular biologic techniques applied in detection of EMC, and presented and assessed in detail the application of three promising tools.

Keywords： microbial community     denaturing gradient gel electrophoresis (DGGE)     terminal restriction fragment length polymorphism    

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G-quadruplex formation of oligonucleotides containing ALS and FTD related GGGGCC repeat

Jasna Brčić,Janez Plavec

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 222-237 doi: 10.1007/s11705-016-1556-4

Abstract: A largely increased number of GGGGCC repeats located in the non-coding region of gene have been identified as the leading cause of two related neurological disorders, familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). We examined G-quadruplex forming ability of GGGGCC-repeat containing oligonucleotides with four guanine tracts chosen as the smallest possible model to form a unimolecular G-quadruplex. These oligonucleotides are readily to folded into G-quadruplexes in the presence of K ions. However, the formation of multiple structures makes structural analysis challenging and time consuming. We observed that flanking sequences on 5'- and 3'-ends as well as mutations of loop residues have a profound effect on folding. Sequence d[(G C ) G ] was chosen for further scrutiny and optimization of nuclear magnetic resonance (NMR) spectroscopic properties with dG to 8Br-dG substitutions at specific positions in the sequence under different folding conditions. Expectedly, folding into desired predominant topology is facilitated when substituted residue adopted a conformation in the naturally-occurring structure. Single dG to 8Br-dG substitution at position 21 and fine tuning of folding conditions facilitate folding of d[(G C ) GG GG] into (mostly) a single G-quadruplex, and thus enable determination of its high-resolution structure by high-field NMR.

Keywords： G-quadruplex     GGGGCC     NMR     ALS/FTD     polymorphism    

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Diversity and vertical distributions of sediment bacteria in an urban river contaminated by nutrients and heavy metals

Xunan YANG, Shan HUANG, Qunhe WU, Renduo ZHANG, Guangli LIU

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 6,   Pages 851-859 doi: 10.1007/s11783-013-0569-1

Abstract: The bacterial OTUs were measured using the terminal restriction fragment length polymorphism analysis

Keywords： heavy metals     nutrients     sediment profile     terminal restriction fragment length polymorphism    

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Novel polymorphic EST-based microsatellite marker isolation and characterization from

Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 60-65 doi: 10.15302/J-FASE-2015048

Abstract: Novel simple sequence repeat (SSR) markers were developed to evaluate their utility for genetic diversity and breeding studies of and related species. A total of 108 primer pairs were characterized by PCR amplification experiments. Among these, 61 were polymorphic and transferable to other citrus species. The number of alleles per locus ranged from 2 to 6, with an average of 2.37 alleles per locus. The expected heterozygosity and observed heterozygosity ranged from 0 to 0.83 and 0 to 1.00, respectively. These novel polymorphic SSR markers will be useful for citrus cultivar identification and evaluation as well as breeding studies.

Keywords： microsatellite     polymorphism     Poncirus trifoliata    

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Title Author Date Type Operation

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Journal Article

Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Journal Article

Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Journal Article

Polymorphism and crystal transformation of penicillin sulfoxide

Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG

Journal Article

Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile

TANG Zhongzhi, LI Junyao, YANG Jianhong

Journal Article

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Journal Article

Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

Journal Article

community structure in different wastewater treatment processes characterized by single-strand conformation polymorphism

ZHAO Yangguo, WANG Aijie, REN Nanqi, ZHAO Yan

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

Current molecular biologic techniques for characterizing environmental microbial community

Dawen GAO, Yu TAO

Journal Article

G-quadruplex formation of oligonucleotides containing ALS and FTD related GGGGCC repeat

Jasna Brčić,Janez Plavec

Journal Article

Diversity and vertical distributions of sediment bacteria in an urban river contaminated by nutrients and heavy metals

Xunan YANG, Shan HUANG, Qunhe WU, Renduo ZHANG, Guangli LIU

Journal Article

Novel polymorphic EST-based microsatellite marker isolation and characterization from

Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG

Journal Article