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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: was designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 909-918 doi: 10.1007/s11684-021-0890-1

Abstract: Results showed that tumor necrosis factor α and interleukin 8 (IL-8) were vital in distinguishing patientsFinally, in-vitro and in-vivo experimental evidence were provided to show that IL-8 influenced

Keywords： acute promyelocytic leukemia     intracranial hemorrhage     cytokines     biomarker    

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: Macrophage was induced by phorbol myristate acetate (PMA) treatment on THP-1 cells.The cells were further stimulated by ox-LDL, ox-LDL plus LPS, ox-LDL plus IL-10 and LPS.However, the significant elevation by LPS was abrogated when IL-10 was added.IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.The inhibitive effect of IL-10 is an important factor for delaying atherosclerosis processes.

Keywords： inflammatory     presence     interleukin-10     dose-dependent     ox-LDL    

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Emergence in cyber-physical systems: potential and risk

Shmuel Tyszberowicz, David Faitelson,tyshbe@tau.ac.il,davidf@afeka.ac.il

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 11,   Pages 1535-1670 doi: 10.1631/FITEE.2000279

Abstract: (CPSs) are distributed assemblages of computing, communicating, and physical components that sense their environment, algorithmically assess the incoming information, and affect their physical environment. Thus, they share a common structure with other , and therefore share both the possible benefits and the probable harmful effects of emergent phenomena. Emergence is an often unexpected pattern that arises from the interactions among the individual system components and the environment. In this paper we focus on three major problems concerning emergence in the context of CPSs: how to successfully exploit emergence, how to avoid its detrimental effects in a single CPS, and how to avoid harmful emergence that arises due to unexpected interaction among several independently developed CPSs that are operating in the same environment. We review the state of the research with regard to these problems and outline several approaches that could be used to address them.
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Decomposition of aqueous chlorinated contaminants by UV irradiation with H

Eunsung KAN,Chang-Il KOH,Kyunghyuk LEE,Joonwun KANG

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 3,   Pages 429-435 doi: 10.1007/s11783-014-0677-6

Abstract: In the present study, the decomposition rates of carbon tetrachloride (CCl ) and 2,4-dichlorophenol (2,4-DCP) in water by the ultraviolet (UV) light irradiation alone and H O /UV were experimentally investigated. The detailed experimental studies have been conducted for examining treatment capacities of the two different ultraviolet light sources (low and medium pressure Hg arc) in H O /UV processes. The low or medium UV lamp alone resulted in a 60%–90% decomposition of 2,4-DCP while a slight addition of H O resulted in a drastic enhancement of the 2,4-DCP decomposition rate. The decomposition rate of 2,4-DCP with the medium pressure UV lamp alone was about 3–6 times greater than the low pressure UV lamp alone. In the direct photolysis of aqueous CCl , the medium pressure UV lamp had advantage over the low pressure UV lamp because the molar extinction coefficient of CCl at shorter wavelength (210–220 nm) is about 20 to 50 times higher than that at 254 nm. However, adding H O to the medium pressure UV lamp system rendered a negative oxidation rate because H O acted as a UV absorber being competitive with CCl due to negligible reaction between CCl and OH radicals. The results from the present study indicated significant influence of the photochemical properties of the target contaminants on the photochemical treatment characteristics for designing cost-effective UV-based degradation of toxic contaminants.

Keywords： H2O2/ultraviolet (UV) light     advanced oxidation     UV light irradiation     chlorinated contaminants     photochemical treatment characteristics    

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Active steering control strategy for articulated vehicles Project supported by the Program for Changjiang Scholars and Innovative Research Team in University, China (No. IRT0626) Article

Kyong-il KIM,Hsin GUAN,Bo WANG,Rui GUO,Fan LIANG

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 6,   Pages 576-586 doi: 10.1631/FITEE.1500211

Abstract: To improve maneuverability and stability of articulated vehicles, we design an active steering controller, including tractor and trailer controllers, based on linear quadratic regulator (LQR) theory. First, a three-degree-of-freedom (3-DOF) model of the tractor-trailer with steered trailer axles is built. The simulated annealing particle swarm optimization (SAPSO) algorithm is applied to identify the key parameters of the model under specified vehicle speed and steering wheel angle. Thus, the key parameters of the simplified model can be obtained according to the vehicle conditions using an online look-up table and interpolation. Simulation results show that vehicle parameter outputs of the simplified model and TruckSim agree well, thus providing the ideal reference yaw rate for the controller. Then the active steering controller of the tractor and trailer based on LQR is designed to follow the desired yaw rate and minimize their side-slip angle of the center of gravity (CG) at the same time. Finally, simulation tests at both low speed and high speed are conducted based on the TruckSim-Simulink program. The results show significant effects on the active steering controller on improving maneuverability at low speed and lateral stability at high speed for the articulated vehicle. The control strategy is applicable for steering not only along gentle curves but also along sharp curves.

Keywords： Articulated vehicle     Sharp curve     Lateral stability     Linear quadratic regulator (LQR)    

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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1044-4

Abstract: Considering that high levels of interleukin-6 (IL-6) have been detected in several highly pathogenicacute respiratory syndrome in 2002, the Middle East respiratory syndrome in 2012, and COVID-19, the ILThus, we review the history of cytokine storm and the process of targeting IL-6 signaling to elucidate

Keywords： SARS-CoV-2     COVID-19     cytokine storm     interleukin-6     tocilizumab    

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Effects of heavy rainfall on the composition of airborne bacterial communities

Gwang Il Jang, Chung Yeon Hwang, Byung Cheol Cho

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 2, doi: 10.1007/s11783-018-1008-0

Abstract: Wet deposition scavenges particles and particle-associated bacteria from the air column, but the impact of raindrops on various surfaces on Earth causes emission of surface-associated bacteria into the air column. Thus, after rainfall, these two mechanisms are expected to cause changes in airborne bacterial community composition (BCC). In this study, aerosol samples were collected at a suburban site in Seoul, Korea before and after three heavy rainfall events in April, May, and July 2011. BCC was investigated by pyrosequencing the 16S rRNA gene in aerosol samples. Interestingly, the relative abundance of non-spore forming operational taxonomic units (OTUs) was always higher in post-rain aerosol samples. In particular, the absolute and relative abundances of airborne always increased after rainfall, whereas those of airborne , including and , consistently decreased. Marine bacterial sequences, which were temporally important in aerosol samples, also decreased after rainfall events. Further, increases in pathogen-like sequences were often observed in post-rain air samples. Rainfall events seemed to affect airborne BCCs by the combined action of the two mechanisms, with potentially adverse effects on human and plant health.

Keywords： Aerosol     Bacteria     Community composition     Pyrosequencing     Rain    

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Adsorption properties of polycarboxylate ether-based superplasticizer on cement particles and their resultant dispersion

Jinyoung YOON; Byoung Il CHOI; Jae Hong KIM

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 4,   Pages 506-514 doi: 10.1007/s11709-022-0813-5

Abstract: The cement dispersion performance of a polycarboxylate (PCE)-based superplasticizer is highly related to their adsorption behaviors as a function of time. This study evaluated effects of PCEs on rheological properties of cementitious materials. First, characteristics of PCEs were characterized via permeation chromatography (GPC) and Fourier-transform infrared spectrometry (FT-IR). The adsorption behavior of single and blended PCEs on cementitious composites was identified using total organic carbon analyzer (TOC). Based on the measurement of PCE adsorption, the changes of rheological properties of cementitious materials as well as the number of dispersed cement particles were characterized using a rheometer and laser spectroscopy, respectively. The experimental results support the systematic mechanism of PCE adsorption, cement dispersion, and the decrease in viscosity of cementitious materials.

Keywords： adsorption     polycarboxylate     superplasticizer     rheology     dispersion    

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Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity

Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 594-607 doi: 10.1007/s11684-020-0809-2

Abstract: Bavachin boosts the secretion of IL-1β and caspase-1 caused by ATP or nigericin but not those inducedtransaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-1β via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.

Keywords： Psoraleae Fructus     bavachin     idiosyncratic drug-induced liver injury     caspase-1     IL-1β     NLRP3 inflammasome    

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Histogram equalization using a reduced feature set of background speakers’ utterances for speaker recognition Article

Myung-jae KIM, Il-ho YANG, Min-seok KIM, Ha-jin YU

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 5,   Pages 738-750 doi: 10.1631/FITEE.1500380

Abstract: We propose a method for histogram equalization using supplement sets to improve the performance of speaker recognition when the training and test utterances are very short. The supplement sets are derived using outputs of selection or clustering algorithms from the background speakers’ utterances. The proposed approach is used as a feature normalization method for building histograms when there are insufficient input utterance samples. In addition, the proposed method is used as an i-vector normalization method in an i-vector-based probabilistic linear discriminant analysis (PLDA) system, which is the current state-of-the-art for speaker verification. The ranks of sample values for histogram equalization are estimated in ascending order from both the input utterances and the supplement set. New ranks are obtained by computing the sum of different kinds of ranks. Subsequently, the proposed method determines the cumulative distribution function of the test utterance using the newly defined ranks. The proposed method is compared with conventional feature normalization methods, such as cepstral mean normalization (CMN), cepstral mean and variance normalization (MVN), histogram equalization (HEQ), and the European Telecommunications Standards Institute (ETSI) advanced front-end methods. In addition, performance is compared for a case in which the greedy selection algorithm is used with fuzzy -means and -means algorithms. The YOHO and Electronics and Telecommunications Research Institute (ETRI) databases are used in an evaluation in the feature space. The test sets are simulated by the Opus VoIP codec. We also use the 2008 National Institute of Standards and Technology (NIST) speaker recognition evaluation (SRE) corpus for the i-vector system. The results of the experimental evaluation demonstrate that the average system performance is improved when the proposed method is used, compared to the conventional feature normalization methods.

Keywords： Speaker recognition     Histogram equalization     i-vector    

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Th17 Cells in autoimmune diseases

Lei Han,Jing Yang,Xiuwen Wang,Dan Li,Ling Lv,Bin Li

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 10-19 doi: 10.1007/s11684-015-0388-9

Abstract:

Th17 cells are a new subset of CD4+ T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sj?gren’s syndrome, inflammatory bowel disease, and multiple sclerosis.

Keywords： IL-17     Th17 cells     RORγt     autoimmune diseases     posttranslational modification     inhibitors    

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Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Strategic Study of CAE 2007, Volume 9, Issue 5,   Pages 91-94

Abstract:

Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.the monotonicity of predicted value and its variation tendency,  applicability criterion of GM(1,1) is brought forward.

Keywords： fire forecast     GM(1     1)     rate of the fire injured    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1,and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Strategic Study of CAE 2011, Volume 13, Issue 10,   Pages 13-18

Abstract: According to this guidance, such giant oilfield JX1-1 was discovered with 150 million reserves in the

Keywords： Bohai Liaodong zone     JX1-1     geological recognition     large oilfield    

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Title Author Date Type Operation

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Journal Article

Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Journal Article

Emergence in cyber-physical systems: potential and risk

Shmuel Tyszberowicz, David Faitelson,tyshbe@tau.ac.il,davidf@afeka.ac.il

Journal Article

Decomposition of aqueous chlorinated contaminants by UV irradiation with H

Eunsung KAN,Chang-Il KOH,Kyunghyuk LEE,Joonwun KANG

Journal Article

Active steering control strategy for articulated vehicles Project supported by the Program for Changjiang Scholars and Innovative Research Team in University, China (No. IRT0626)

Kyong-il KIM,Hsin GUAN,Bo WANG,Rui GUO,Fan LIANG

Journal Article

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Journal Article

Effects of heavy rainfall on the composition of airborne bacterial communities

Gwang Il Jang, Chung Yeon Hwang, Byung Cheol Cho

Journal Article

Adsorption properties of polycarboxylate ether-based superplasticizer on cement particles and their resultant dispersion

Jinyoung YOON; Byoung Il CHOI; Jae Hong KIM

Journal Article

Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity

Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai

Journal Article

Histogram equalization using a reduced feature set of background speakers’ utterances for speaker recognition

Myung-jae KIM, Il-ho YANG, Min-seok KIM, Ha-jin YU

Journal Article

Th17 Cells in autoimmune diseases

Lei Han,Jing Yang,Xiuwen Wang,Dan Li,Ling Lv,Bin Li

Journal Article

Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Journal Article