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Digital microfluidics: A promising technique for biochemical applications

He WANG, Liguo CHEN, Lining SUN

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4,   Pages 510-525 doi: 10.1007/s11465-017-0460-z

Abstract:

Digital microfluidics (DMF) is a versatile microfluidics technology that has significant application potential in the areas of automation and miniaturization. In DMF, discrete droplets containing samples and reagents are controlled to implement a series of operations via electrowetting-on-dielectric. This process works by applying electrical potentials to an array of electrodes coated with a hydrophobic dielectric layer. Unlike microchannels, DMF facilitates precise control over multiple reaction processes without using complex pump, microvalve, and tubing networks. DMF also presents other distinct features, such as portability, less sample consumption, shorter chemical reaction time, flexibility, and easier combination with other technology types. Due to its unique advantages, DMF has been applied to a broad range of fields (e.g., chemistry, biology, medicine, and environment). This study reviews the basic principles of droplet actuation, configuration design, and fabrication of the DMF device, as well as discusses the latest progress in DMF from the biochemistry perspective.

Keywords： digital microfluidics     electrowetting on dielectric     discrete droplet     biochemistry    

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Rise of aluminum-chalcogen batteries: A promising path to sustainable energy storage

Frontiers in Energy 2023, Volume 17, Issue 5,   Pages 567-568 doi: 10.1007/s11708-023-0887-3

Abstract: Rise of aluminum-chalcogen batteries: A promising path to sustainable energy storage

Keywords： promising path energy    

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Engineering the grain boundary: a promising strategy to configure NiCoPO/NiCoP nanowire arrays for ultra-stable

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8,   Pages 1259-1267 doi: 10.1007/s11705-021-2132-0

Abstract: than those of other work, demonstrating as-prepared NiCoP4O12/NiCoP arrays are promising

Keywords： NiCo     array electrode     grain boundary     stability     supercapacitor    

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Discovery of cryptolepine derivatives as novel promising agents against phytopathogenic bacteria

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 156-166 doi: 10.1007/s11705-022-2196-5

Abstract: In vivo experiments demonstrated the promising applicability of compound 9 for

Keywords： cryptolepine derivatives     phytopathogenic bacteria     antibacterial activity     mechanism of action    

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Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 351-355 doi: 10.1007/s11684-010-0320-2

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Iterative HOEO fusion strategy: a promising tool for enhancing bearing fault feature

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0725-z

Abstract: As parameter independent yet simple techniques, the energy operator (EO) and its variants have received considerable attention in the field of bearing fault feature detection. However, the performances of these improved EO techniques are subjected to the limited number of EOs, and they cannot reflect the non-linearity of the machinery dynamic systems and affect the noise reduction. As a result, the fault-related transients strengthened by these improved EO techniques are still subject to contamination of strong noises. To address these issues, this paper presents a novel EO fusion strategy for enhancing the bearing fault feature nonlinearly and effectively. Specifically, the proposed strategy is conducted through the following three steps. First, a multi-dimensional information matrix (MDIM) is constructed by performing the higher order energy operator (HOEO) on the analysis signal iteratively. MDIM is regarded as the fusion source of the proposed strategy with the properties of improving the signal-to-interference ratio and suppressing the noise in the low-frequency region. Second, an enhanced manifold learning algorithm is performed on the normalized MDIM to extract the intrinsic manifolds correlated with the fault-related impulses. Third, the intrinsic manifolds are weighted to recover the fault-related transients. Simulation studies and experimental verifications confirm that the proposed strategy is more effective for enhancing the bearing fault feature than the existing methods, including HOEOs, the weighting HOEO fusion, the fast Kurtogram, and the empirical mode decomposition.

Keywords： higher order energy operator     fault diagnosis     manifold learning     rolling element bearing     information fusion    

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Sodium cellulose sulfate: A promising biomaterial used for microcarriers’ designing

Qing-Xi Wu, Yi-Xin Guan, Shan-Jing Yao

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 46-58 doi: 10.1007/s11705-018-1723-x

Abstract: materials for human health and economy services, more and more natural renewable biomass are regarded as promisingAnd promising applications of NaCS used as biomaterials for microcarriers’ designing, such as micro-cell-carriers

Keywords： sodium cellulose sulfate     biomaterial     physicochemical properties     microcarriers    

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Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment

Frontiers in Energy 2022, Volume 16, Issue 6,   Pages 931-942 doi: 10.1007/s11708-021-0771-y

Abstract: energy transition provide an important pathway for high-efficiency energy deployment and may lead to promising

Keywords： microwave discharge     high-energy sites     targeted-energy transition     morphology design     energy efficiency    

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Nickel nanopore arrays as promising current collectors for constructing solid-state supercapacitors with

Huaping Zhao, Long Liu, Yaoguo Fang, Ranjith Vellacheri, Yong Lei

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 339-345 doi: 10.1007/s11705-018-1699-6

Abstract:

In this work, nickel nanopore arrays with a highly-oriented nanoporous structure inherited from porous alumina membranes were used as nanostructured current collectors for constructing ultrahigh rate solid-state supercapacitors. A thin layer of poly(3,4-ethylenedioxythiophene) (PEDOT) as electroactive materials was conformally coated onto nickel nanopores to form heterostructured electrodes. The as-prepared electrodes have a large specific surface area to ensure a high capacity, and the highly-oriented nanoporous structure of nickel nanopores reduces the ion transport resistance, allowing the ions in the solid-state electrolytes to quickly access the PEDOT surface during the fast charge-discharge process. As a result, the assembled solid-state supercapacitor in a symmetric configuration exhibits an ideal capacitive behavior and a superior rate capability even at an ultrahigh scan rate of 50 V·s−1.

Keywords： supercapacitor     ultrahigh rate     metallic nanopore arrays     current collectors     PEDOT    

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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Zika virus (ZIKV) is an emerging pathogen associated with neurological complications, such as Guillain–Barré syndrome in adults and microcephaly in fetuses and newborns. This mosquito-borne flavivirus causes important social and sanitary problems owing to its rapid dissemination. However, the development of antivirals against ZIKV is lagging. Although various strategies have been used to study anti-ZIKV agents, approved drugs or vaccines for the treatment (or prevention) of ZIKV infections are currently unavailable. Repurposing clinically approved drugs could be an effective approach to quickly respond to an emergency outbreak of ZIKV infections. The well-established safety profiles and optimal dosage of these clinically approved drugs could provide an economical, safe, and efficacious approach to address ZIKV infections. This review focuses on the recent research and development of agents against ZIKV infection by repurposing clinical drugs. Their characteristics, targets, and potential use in anti-ZIKV therapy are presented. This review provides an update and some successful strategies in the search for anti-ZIKV agents are given.

Keywords： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Deep eutectic ionic liquids based on DABCO-derived quaternary ammonium salts: A promising reaction medium

Muhammad Faisal, Azeem Haider, Quret ul Aein, Aamer Saeed, Fayaz Ali Larik

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3,   Pages 586-598 doi: 10.1007/s11705-018-1788-6

Abstract: Owing to the directional H-bonding, coordination and -stacking abilities, terpyridines have been widely used as supramolecular tectons in molecular architectures, skeletons in molecular devices and metallopolymers, and are gaining importance in medicinal chemistry. In this paper, we have synthesized, characterized and applied deep eutectic ionic liquids (DEILs) based on 1,4-diazabicyclo[2.2.2]octane; triethylenediamine (DABCO)-derived quaternary ammonium salts for the preparation of terpyridines. These DEILs were synthesized through -alkylation of DABCO with haloalkanes (1-bromopentane or 1-bromoheptane) followed by mixing and heating with methanol or polyethylene glycol as a hydrogen bond donor. The synthesized DEILs were structurally characterized by IR and NMR. The formation of deep eutectic solvent was confirmed by freezing point depression, it composition was investigated through phase diagram, and its thermal stability was determined through differential scanning calorimetry, derivative thermogravimetry and thermal gravimetric analysis studies. Further, theseDEILswereinvestigatedfor theireffectivenesstowards synthesis of 2,2′:6′,2″-terpyridine, 3,2′:6′,3″-terpyridineand 4,2′:6′,4″-terpyridinederivatives through Kröhnke reaction. The results show that these three types of terpyridines can be obtained in reasonable yields (80% 97%) by the one-pot reaction of 2-, 3- or 4-acetylpyridine with a variety of aromatic aldehydes in the presence of DEIL as a reaction medium, sodium hydroxide as a base and ammonium acetate as a cyclizing agent. This methodology is highly efficient and cost-effective for synthesis of symmetrical as well as unsymmetrical terpyridines. Importantly, these DEILs can be reused several times without an obvious loss of activity and are non-toxic, low-volatile, biodegradable and highly thermally stable. Therefore, these DEILs as a non-conventional reaction medium for the synthesis of terpyridines provides appealing opportunities to be investigated in the domain of green synthesis.

Keywords： terpyridine     deep eutectic solvent     ionic liquid     Kröhnke reaction     DABCO    

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Promising approach for preparing metallic single-atom catalysts: electrochemical deposition

Frontiers in Energy 2022, Volume 16, Issue 4,   Pages 537-541 doi: 10.1007/s11708-022-0837-5

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Chimeric antigen receptor T-cell therapy: a promising treatment modality for relapsed/refractory mantle

Ping Li, Ningxin Dong, Yu Zeng, Jie Liu, Xiaochen Tang, Junbang Wang, Wenjun Zhang, Shiguang Ye, Lili Zhou, Alex Hongsheng Chang, Aibin Liang

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 811-815 doi: 10.1007/s11684-020-0740-6

Abstract: This report suggested that CAR T-cell therapy is a promising treatment modality for patients with MCL

Keywords： anti-CD19 chimeric antigen receptor T cells     mantle cell lymphoma     relapsed or refractory     long-term follow-up    

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Current progress on scaffolds of tissue engineering heart valves

DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 229-234 doi: 10.1007/s11684-008-0043-9

Abstract: Tissue engineering heart valves (TEHV) may be the most promising valve substitute, but the study has

Keywords： function     scaffold     promising     research     engineering    

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Benzene conversion by manganese dioxide assisted silent discharge plasma

LU Bin, JI Min, YU Xin, FENG Tao, YAO Shuiliang

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 4,   Pages 477-481 doi: 10.1007/s11783-007-0076-3

Abstract: Non-thermal plasma technologies have shown their promising potential specially for the low concentration

Keywords： consuming     Non-thermal     promising     volatile     compound    

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Title Author Date Type Operation

Digital microfluidics: A promising technique for biochemical applications

He WANG, Liguo CHEN, Lining SUN

Journal Article

Rise of aluminum-chalcogen batteries: A promising path to sustainable energy storage

Journal Article

Engineering the grain boundary: a promising strategy to configure NiCoPO/NiCoP nanowire arrays for ultra-stable

Journal Article

Discovery of cryptolepine derivatives as novel promising agents against phytopathogenic bacteria

Journal Article

Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Journal Article

Iterative HOEO fusion strategy: a promising tool for enhancing bearing fault feature

Journal Article

Sodium cellulose sulfate: A promising biomaterial used for microcarriers’ designing

Qing-Xi Wu, Yi-Xin Guan, Shan-Jing Yao

Journal Article

Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment

Journal Article

Nickel nanopore arrays as promising current collectors for constructing solid-state supercapacitors with

Huaping Zhao, Long Liu, Yaoguo Fang, Ranjith Vellacheri, Yong Lei

Journal Article

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Journal Article

Deep eutectic ionic liquids based on DABCO-derived quaternary ammonium salts: A promising reaction medium

Muhammad Faisal, Azeem Haider, Quret ul Aein, Aamer Saeed, Fayaz Ali Larik

Journal Article

Promising approach for preparing metallic single-atom catalysts: electrochemical deposition

Journal Article

Chimeric antigen receptor T-cell therapy: a promising treatment modality for relapsed/refractory mantle

Ping Li, Ningxin Dong, Yu Zeng, Jie Liu, Xiaochen Tang, Junbang Wang, Wenjun Zhang, Shiguang Ye, Lili Zhou, Alex Hongsheng Chang, Aibin Liang

Journal Article

Current progress on scaffolds of tissue engineering heart valves

DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping

Journal Article

Benzene conversion by manganese dioxide assisted silent discharge plasma

LU Bin, JI Min, YU Xin, FENG Tao, YAO Shuiliang

Journal Article