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The antibiotic resistome: gene flow in environments, animals and human beings
Yongfei Hu, George F. Gao, Baoli Zhu
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 161-168 doi: 10.1007/s11684-017-0531-x
Keywords: antibiotic resistance resistome microbiome gene flow
Antibiotic resistome of : molecular determinants for the emergence of drug resistance
Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 693-703 doi: 10.1007/s11684-020-0777-6
Keywords: S. typhi antibiotic resistance mechanism resistome identification methods
Antibiotic resistome mostly relates to bacterial taxonomy along a suburban transmission chain
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 3, doi: 10.1007/s11783-021-1466-7
• The α-diversities of resistome were lower in manure and compost than
Keywords: Antibiotic resistance genes Resistome Bacterial taxonomy Transmission chain
Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu
Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1189-1
Keywords: Drinking water treatment Antibiotic resistance gene Biofiltration Chlorination
Culturomics and metagenomics: In understanding of environmental resistome
Monika Nowrotek, Łukasz Jałowiecki, Monika Harnisz, Grażyna Anna Płaza
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1121-8
State of the art of culturomics and metagenomics to study resistome
Keywords: Culturomics Metagenomics Antibiotic resistance Resistome
Ziming Han, Haodi Feng, Xiao Luan, Yunpeng Shen, Liren Ren, Liujie Deng, D.G. Joakim Larsson, Michael Gillings, Yu Zhang, Min Yang
Engineering 2022, Volume 15, Issue 8, Pages 78-88 doi: 10.1016/j.eng.2022.05.011
Fermentation-based antibiotic production results in abundant nutrient-rich fermentation residue with high potential for recycling, but the high antibiotic residual concentration restricts its usefulness (e.g., in land application as organic fertilizer). In this study, an industrial-scale hydrothermal facility for the treatment of erythromycin fermentation residue (EFR) was investigated, and the potential risk of the long-term soil application of treated EFR promoting environmental antibiotic resistance development was evaluated. The treatment effectively removed bacteria and their DNA, and an erythromycin removal ratio of up to approximately 98% was achieved. The treated EFR was utilized as organic fertilizer for consecutive field applications from 2018 to 2020, with dosages ranging from 3750 to 15 000 kg∙hm-2, resulting in sub-inhibitory levels of erythromycin (ranging from 0.83–76.00 μg∙kg-1) in soils. Metagenomic shotgun sequencing was then used to characterize the antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and bacterial community composition of the soils. The soil ARG abundance and diversity did not respond to the treated EFR application in the first year, but gradually changed in the second and third year of application. The highest fold change in relative abundance of macrolide-lincosamidestreptogramin (MLS) and total ARGs were 12.59 and 2.75 times, compared with the control (CK; without application), respectively. The soil MGEs and taxonomic composition showed similar temporal trends to those of the ARGs, and appeared to assist in driving increasing ARG proliferation, as revealed by correlation analysis and structural equation models (SEMs). The relative abundance of particular erm resistance genes (RNA methyltransferase genes) increased significantly in the third year of treated EFR application. The close association of erm with MGEs suggested that horizontal gene transfer played a critical role in the observed erm gene enrichment. Metagenomic binning results demonstrated that the proliferation of mac gene-carrying hosts was responsible for the increased abundance of mac genes (efflux pump genes). This study shows that sub-inhibitory levels of erythromycin in soils had a cumulative effect on soil ARGs over time and emphasizes the importance of long-term monitoring for assessing the risk of soil amendment with treated industrial waste.
Keywords: Pharmaceutical manufacturing Resistome Antibiotic Risk assessment Remediation Land application
Title Author Date Type Operation
The antibiotic resistome: gene flow in environments, animals and human beings
Yongfei Hu, George F. Gao, Baoli Zhu
Journal Article
Antibiotic resistome of : molecular determinants for the emergence of drug resistance
Journal Article
Antibiotic resistome mostly relates to bacterial taxonomy along a suburban transmission chain
Journal Article
Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review
Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu
Journal Article
Culturomics and metagenomics: In understanding of environmental resistome
Monika Nowrotek, Łukasz Jałowiecki, Monika Harnisz, Grażyna Anna Płaza
Journal Article
Three-Year Consecutive Field Application of Erythromycin Fermentation Residue Following Hydrothermal Treatment: Cumulative Effect on Soil Antibiotic Resistance Genes
Ziming Han, Haodi Feng, Xiao Luan, Yunpeng Shen, Liren Ren, Liujie Deng, D.G. Joakim Larsson, Michael Gillings, Yu Zhang, Min Yang
Journal Article