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Journal Article 4

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2021 1

2018 1

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2009 1

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resveratrol 4

AMPK 1

DNA assembly 1

aromatic amino acid 1

autophagy 1

cerebral ischemia 1

gene overexpression 1

integrin-β1 1

liver fibrosis 1

mTOR 1

metabolic engineering 1

mitochondrial metabolism 1

neuronal differentiation 1

neuronal progenitor cells 1

positron emission tomography 1

reactive oxygen species 1

tissue inhibitor of metalloproteinase-1 1

tumor growth factor-β 1

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Profiling influences of gene overexpression on heterologous resveratrol production in

Duo Liu,Bingzhi Li,Hong Liu,Xuejiao Guo,Yingjin Yuan

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 117-125 doi: 10.1007/s11705-016-1601-3

Abstract: Metabolic engineering of heterologous resveratrol production in faces challenges as the precursor L-tyrosineoverexpressed the main gene targets in the upstream pathways to investigate their influences on the downstream resveratrolSingle-gene overexpression and DNA assembly-directed multigene overexpression affect the production of resveratrolFinally, the collaboration of selected gene targets leads to an optimal resveratrol production of 66.14deoxy-D-arabino-heptulosonate-7-phosphate synthase, and expressing 4-coumaryl-CoA ligase show notable positive impacts on resveratrol

Keywords： resveratrol     aromatic amino acid     DNA assembly     metabolic engineering     gene overexpression    

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Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 697-706 doi: 10.1007/s11684-018-0655-7

Abstract: The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelialWe found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aorticResveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROSResveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway.Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy

Keywords： resveratrol     reactive oxygen species     AMPK     mTOR     autophagy    

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Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor

Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 472-485 doi: 10.1007/s11684-021-0832-y

Abstract: metabolism of hypoxia-conditioned NPCs (hcNPCs) was upregulated via the additional administration of resveratrolResveratrol was first applied during the neuronal differentiation of hcNPCs and concurrently promotedResveratrol promoted neuronal differentiation and increased the long-term survival of transplanted hcNPCs. 18-fluorine fluorodeoxyglucose positron emission tomography and rotarod test showed that resveratrolIn conclusion, resveratrol promoted the neuronal differentiation and therapeutic efficiency of hcNPCs

Keywords： neuronal progenitor cells     resveratrol     cerebral ischemia     neuronal differentiation     mitochondrial metabolism    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: to explore the expression of integrin-β1 in different stages of hepatic fibrosis and intervention of resveratrolHepatic fibrosis models of male Sprague Dawley (SD) rats were created and intragastric administration of resveratroleach group in different stages of hepatic fibrosis was tested to judge the therapeutic efficacy of resveratrolResveratrol could improve the degree of hepatic fibrosis of SD rats and decrease the expression of integrin-β1

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Title Author Date Type Operation

Profiling influences of gene overexpression on heterologous resveratrol production in

Duo Liu,Bingzhi Li,Hong Liu,Xuejiao Guo,Yingjin Yuan

Journal Article

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Journal Article

Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor

Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article