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tumorigenesis 2

ALKBH5 1

DNA damage repair 1

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FOXM1 1

FOXO3a 1

Gut microbiota 1

Hepatocellular carcinoma 1

MOF 1

N6-methyladenosine 1

Nonalcoholic fatty liver disease 1

PRMT6 1

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Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 344-356 doi: 10.1007/s11684-023-1028-4

Abstract: ALKBH5 is a master regulator of N6-methyladenosine (m6A) modification, which plays a crucial role in many biological processes. Here, we show that ALKBH5 is required for breast tumor growth. Interestingly, PRMT6 directly methylates ALKBH5 at R283, which subsequently promotes breast tumor growth. Furthermore, arginine methylation of ALKBH5 by PRMT6 increases LDHA RNA stability via m6A demethylation, leading to increased aerobic glycolysis. Moreover, PRMT6-mediated ALKBH5 arginine methylation is confirmed in PRMT6-knockout mice. Collectively, these findings identify a PRMT6-ALKBH5-LDHA signaling axis as a novel target for the treatment of breast cancer.

Keywords： PRMT6     ALKBH5     N6-methyladenosine     glycolysis     tumor growth    

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The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Engineering 2017, Volume 3, Issue 1,   Pages 110-114 doi: 10.1016/J.ENG.2017.01.017

Abstract: It is surprising that the role of the microbiota in tumorigenesis has only recently been recognized,

Keywords： Gut microbiota     Dysbiosis     Tumorigenesis     Hepatocellular carcinoma     Nonalcoholic fatty liver disease    

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Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 79-83 doi: 10.1007/s11684-014-0314-6

Abstract: In this study, we discuss the important roles of MOF in DNA damage repair, apoptosis, and tumorigenesis

Keywords： MOF     histone acetyltransferase     DNA damage repair     tumorigenesis     embryonic stem cells    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Title Author Date Type Operation

Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

Journal Article

The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Journal Article

Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article