
First Pig-to-Live Human Xenotransplant Produces Mixed Results
Sarah C.P. Williams
Engineering ›› 2022, Vol. 16 ›› Issue (9) : 6-8.
First Pig-to-Live Human Xenotransplant Produces Mixed Results
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University of Maryland School of Medicine faculty scientists and clinicians perform historic transplant of porcine heart into adult human with end-stage heart disease [Internet]. Baltimore: University of Maryland Medical Center; 2022 Jan 10 [cited 2022 Jun 10]. Available from: https://www.umms.org/ ummc/news/2022/pioneering-transplant-of-porcine-heart-into-adult-humanheart.
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Regalado A. The gene-edited pig heart given to a dying patient was infected with a pig virus [Internet]. Cambridge: MIT Technology Review; 2022 May 4 [cited 2022 Jun 10]. Available from: https://www.technologyreview.com/ 2022/05/04/1051725/xenotransplant-patient-died-received-heart-infectedwith-pig-virus/.
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Goerlich CE, Griffith B, Hanna P, Hong SN, Ayares D, Singh AK, et al. The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors. J Thorac Cardiovasc Surg. In press.
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Servick K. Here’s how scientists pulled off the first pig-to-human heart transplant [Internet]. Washington, DC: Science Insider; 2022 Jan 12 [cited 2022 Jun 10]. Available from: https://www.science.org/content/article/here-s-howscientists-pulled-first-pig-human-heart-transplant.
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Mohiuddin MM, Singh AK, Corcoran PC, Thomas III ML, Clark T, Lewis BG, et al. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nat Commun 2016;7:11138.
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Greer T. UAB announces first clinical-grade transplant of gene-edited pig kidneys into brain-dead human [Internet]. Birmingham: University of Alabama; 2022 Jan 20 [cited 2022 Jun 10]. Available from: https://www.uab. edu/news/campus/item/12566-uab-announces-first-clinical-grade-transplantof-gene-edited-pig-kidneys-into-brain-dead-human.
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Montgomery RA, Stern JM, Lonze BE, Tatapudi VS, Mangiola M, Wu M, et al. Results of two cases of pig-to-human kidney xenotransplantation. N Engl J Med 2022;386:1889–98.
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Yue Y, Xu W, Kan Y, Zhao HY, Zhou Y, Song X, et al. Extensive germline genome engineering in pigs. Nat Biomed Eng 2021;5:134–43.
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[[12]] |
First heart transplant performed 35 years ago [Internet]. Washington, DC: Organ Procurement and Transplantation Network; 2002 Dec 3 [cited 2022 Jun 10]. Available from: https://optn.transplant.hrsa.gov/news/first-hearttransplant-performed-35-years-ago/.
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