2026-02-28 , Volume 57 Issue 2

Cover illustration

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    Long rooted in its central dogma of DNA → RNA → protein, molecular biology is now outgrowing this linear framework. Glycans are emerging as “molecular keys” that drive the paracentral dogma, which positions glycosylation as a core regulatory layer alongside nucleic acids and proteins. This special issue centers on this conceptual shift, sparked by Wei Wang’s provocative question: “Can DNA be glycosylated?” The discovery of glycoRNAs, the first validated glycan keys, is reshaping our understanding of immune signaling, while putative DNA glycosylation points to a new dimension of epigenetic control. We have invited interdisciplinary contributions addressing glycan-based mechanisms, biomarkers, and enabling technologies and now invite readers to join us in exploring this uncharted territory. The future of molecular medicine is not written solely in codons; it also lies in the precise “teeth” of glycan keys.


  • Select all
    Editorial
  • Editorial
    Glycomedicine: Unveiling the Paracentral Dogma
    Wei Wang , Gordan Lauc

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • News & Highlights
  • News
    Is the Brain Drain Reversing?
    Mitch Leslie

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Views & Comments
  • Correspondence
    Can DNA Be Glycosylated?
    Wei Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Correspondence
    Phenotype-Target Coupled Drug Screening: A High-Efficiency Framework for Innovative Drug Discovery from CHMs
    Wei Zhou , Yue Gao

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Correspondence
    Optimizing Cholesterol Management Strategies Based on Cholesterol-Mortality Associations
    Jianxin Li , Xiangfeng Lu

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Correspondence
    From Flu to Therapy: Development of Influenza Viruses as Platforms for Combating Infections and Cancer
    Demin Zhou , Dezhong Ji , Jiandong Jiang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Correspondence
    Vision Sensing for Intelligent Driving: Technical Challenges and Innovative Solutions
    Xinle Gong , Zhihua Zhong

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research
  • research-article
    New Avenues for Human Blood Plasma Biomarker Discovery via Improved In-Depth Analysis of the Low-Abundant N-Glycoproteome
    Frania J. Zuniga-Banuelos , Marcus Hoffmann , Udo Reichl , Erdmann Rapp

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    GlycoPro: A High-Throughput Sample-Processing Platform for Multi-Glycosylation-Omics Analysis
    Xuejiao Liu , Yue Meng , Bin Fu , Haoru Song , Bing Gu , Ying Zhang , Haojie Lu

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Ablation of ST6Gal-I Downregulates BACE1 Expression and Suppresses Production of Aβ42 Plaques in Alzheimer’s Disease
    Kangkang Yang , Xueying Li , Minchao Lai , Weiwei Zhao , Wanli Song , Shaobin Chen , Wenzhe Li

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    IgG Fucosylation: An Emerging Key Player in the Treatment of Severe COVID-19
    Caiping Zhao , Jingrong Wang , Yuan Liu , Baoling Shang , Danna Lin , Yao Xiao , Hong Ren , Yue Li , Wen Rui , Xu Zou , Hudan Pan , Liang Liu

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Contrasting Macroevolutionary Patterns in the Human N-Glycosylation Pathway
    Domagoj Kifer , Nina Čorak , Mirjana Domazet-Lošo , Niko Kasalo , Gordan Lauc , Göran Klobučar , Tomislav Domazet-Lošo

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Deep Reinforcement Learning-Driven Multi-Omics Integration for Constructing gtAge: A Novel Aging Clock from the IgG N-Glycome and Blood Transcriptome
    Yao Xia , Syed Mohammed Shamsul Islam , Xingang Li , Abdul Baten , Xuerui Tan , Wei Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics
    Huijuan Zhao , Jiteng Fan , Jing Han , Wenjun Qin , Jichen Sha , Weilong Zhang , Yong Gu , Xiaonan Ma , Jianxin Gu , Shifang Ren

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    The Serum-Derived Extracellular Vesicle N-Glycome as a New Biosignature for Childhood Epilepsy
    Yuanyuan Liu , Yanbin Guo , Changzhen Li , Zhiwen Huang , Xiang Liu , Han Xie , Wenhui Wang , Lili Guan , Bi-Feng Liu , Si Liu , Guoping Wang , Xin Liu

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    A Comparative Mechanistic Study of Live-Cell Glycocalyx Engineering: Improving Adoptive Cell Therapies Against B Lymphoma
    Yuxin Li , Tao Gao , Zhaoxin Han , Valeria M. Stepanova , Han Wang , Hongmin Chen , Alexey Stepanov , Senlian Hong

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Fucosylated IgG Contributes to Adipose Tissue Dysfunction During Aging
    Jingyu Wang , Wei Su , Haotian Wang , Licui Liu , Jinlong Li , Youxin Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Moving Beyond a Zero Tolerance Mindset: Embracing Action Errors in Construction
    Peter E.D. Love , Jane Matthews , Weili Fang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Targeting Plasmid Conjugation with Cinnamic Acid: A Novel Approach to Combat Antibiotic Resistance
    Gong Li , Ang Gao , Xin-Yi Lu , Tian-Hong Zhou , Shi-Ying Zhou , Li-Juan Xia , Lei Wan , Yu-Zhang He , Xin-Yi Chen , Wen-Ying Guo , Jia-Min Zheng , Hao Ren , Sheng-Qiu Tang , Xiao-Ping Liao , Liang Chen , Jian Sun

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Halotolerant PGPB Delivered by Drip Irrigation Improve Crop Yield and Quality Through Changes in the Soil Bacterial Community
    Yunpeng Zhou , Bernard R. Glick , Hassan Etesami , Hongbang Liang , Felipe Bastida , Xin Wu , Naikun Kuang , Yunkai Li

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Multi-Frequency Dual-Echo Magnetic Resonance Imaging for Real-Time and Artifact-Free Magnetic Robot Navigation
    Renkuan Zhai , Zhangqi Pan , Yuanshi Kou , Chuang Yang , Yang Ruan , Chenli Xu , Linjie He , Jianfeng Zang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Real-Time Machine Learning-Based Position Recognition in Laser Nanofabrication with Sub-Half-Wavelength Precision
    Hao Zhang , Jinchuan Zheng , Guiyuan Cao , Han Lin , Baohua Jia

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Superior Electrocatalytic Oxygen Evolution of Nickel-Based Metals Modulated by Controllable Graphene Layers via Interfacial Redox Process
    Zhibin Liu , Dashuai Wang , Xinyi Tan , Libin Zeng , Xianyun Peng , Bin Yang , Zhongjian Li , Lecheng Lei , Yang Hou

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Rational Modulation of Pt d Electrons to Significantly Enhance the Catalytic Dehydrogenation Performance of Liquid Organic Hydrogen Carriers
    Chao Sun , Tianzuo Wang , Ruijie Gao , Xiaoyang Liu , Kang Xue , Chengxiang Shi , Xiangwen Zhang , Lun Pan , Ji-Jun Zou

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Neural Network-Based Switching Output Regulation Control for High-Speed Nano-Positioning Stages
    Hongwei Sun , Ning Xing , Jiayu Zou , Yuqi Rong , Yang Shi , Han Ding , Hai-Tao Zhang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Metagenomics and Metabolomics Reveal Intrinsic Drivers of Pyrite-Based Mixotrophic Denitrifying Biofilters: Microbial Spatial Stratification, Nitrogen Removal Pathways, and Key Metabolites
    Qi Zhou , Weizhong Wu , Jianlong Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Regulation of Sleep and Circadian Rhythms by S-Adenosylmethionine-Producing Probiotics
    Peijun Tian , Yuming Lan , Zhiying Jin , Feng Hang , Xuhua Mao , Xing Jin , Gang Wang , Wei Chen

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Non-Traditional and Natural Pozzolans as Precursors for Sustainable Alkali-Activated Binders: Reactivity, Phase Assemblage, and Composition Analysis
    Roshan Muththa Arachchige , Shubham Mishra , Jan Olek , Farshad Rajabipour , Sulapha Peethamparan

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • research-article
    Performance Assessment of Reinforced Concrete Structures Using Self-Sensing Steel Fiber-Reinforced Polymer Composite Bars: Theory and Test Validation
    Zenghui Ye , Zhongfeng Zhu , Feng Xing , Yingwu Zhou

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.