Marine corrosion and biofouling are challenges that affect marine industrial equipment, and protecting equipment with functional coatings is a simple and effective approach. However, it is extremely difficult to combine anti-corrosion and anti-fouling properties in a single coating. In this work, we combine reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) with a hydrophilic polymer in a bio-based silicone-epoxy resin to create a coating with both anti-fouling and anti-corrosion properties. The excellent anti-fouling performance of the coating results from a ternary synergistic mechanism involving fouling release, contact inhibition, and a hydration effect, while the outstanding anti-corrosion performance is provided by a ternary synergistic anti-corrosion mechanism that includes a dense interpenetrating network (IPN) structure, a barrier effect, and passivation. The results show that the obtained coating possesses superior anti-fouling activity against protein, bacteria, algae, and other marine organisms, as well as excellent anti-corrosion and certain self-healing properties due to its dynamic cross-linked network of rGO/AgNPs and the hydrophilic polymer. This work provides an anti-corrosion and anti-fouling integrated coating for marine industrial equipment.