The Anticancer Potential of Quassinoids-A Mini-Review

Engineering ›› 2024, Vol. 38 ›› Issue (7) : 34 -47. DOI: 10.1016/j.eng.2023.11.022

Research

Review

Cai Lu ^a^,^b
, Si-Nan Lu ^a^,^b
, Di Di ^a^,^b
, Wei-Wei Tao ^c
, Lu Fan ^d
, Jin-Ao Duan ^a^,^b
, Ming Zhao ^a^,^b^,^e^,^*
, Chun-Tao Che ^e^,^*

Author information +

History +

Received	Accepted	Published
2023-07-04	2023-11-09	2024-07-01
Issue Date	Revised Date
2024-06-14	2023-10-02

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Abstract

The anticancer potential of quassinoids has attracted a great deal of attention for decades, and scientific data revealing their possible applications in cancer management are continuously increasing in the literature. Aside from the potent cytotoxic and antitumor properties of these degraded triterpenes, several quassinoids have exhibited synergistic effects with anticancer drugs. This article provides an overview of the potential anticancer properties of quassinoids, including their cytotoxic and antitumor activities, mechanisms of action, safety evaluation, and potential benefits in combination with anticancer drugs.

Graphical abstract

Keywords

Quassinoid / Anticancer potential / Antiproliferative mechanism / Safety evaluation / Synergistical combination with anticancer / drugs

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Cai Lu, Si-Nan Lu, Di Di, Wei-Wei Tao, Lu Fan, Jin-Ao Duan, Ming Zhao, Chun-Tao Che, , , , , , , , . The Anticancer Potential of Quassinoids-A Mini-Review. Engineering, 2024, 38(7): 34-47 DOI:10.1016/j.eng.2023.11.022