
Progress in Organ Bioprinting for Regenerative Medicine
Xiang Wang, Di Zhang, Yogendra Pratap Singh, Miji Yeo, Guotao Deng, Jiaqi Lai, Fei Chen, Ibrahim T. Ozbolat, Yin Yu
Engineering ›› 2024, Vol. 42 ›› Issue (11) : 121-142.
Progress in Organ Bioprinting for Regenerative Medicine
Organ damage or failure arising from injury, disease, and aging poses challenges due to the body’s limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional (3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.
Organ printing / Three-dimensional bioprinting / Regenerative medicine / Tissue engineering
[1] |
|
[2] |
|
[3] |
|
[4] |
|
[5] |
|
[6] |
|
[7] |
|
[8] |
|
[9] |
|
[10] |
|
[11] |
|
[12] |
|
[13] |
|
[14] |
|
[15] |
|
[16] |
|
[17] |
|
[18] |
|
[19] |
|
[20] |
|
[21] |
|
[22] |
|
[23] |
|
[24] |
|
[25] |
|
[26] |
|
[27] |
|
[28] |
|
[29] |
|
[30] |
|
[31] |
|
[32] |
|
[33] |
|
[34] |
|
[35] |
|
[36] |
|
[37] |
|
[38] |
|
[39] |
|
[40] |
|
[41] |
|
[42] |
|
[43] |
|
[44] |
|
[45] |
|
[46] |
|
[47] |
|
[48] |
|
[49] |
|
[50] |
|
[51] |
|
[52] |
|
[53] |
|
[54] |
|
[55] |
|
[56] |
|
[57] |
|
[58] |
|
[59] |
|
[60] |
|
[61] |
|
[62] |
|
[63] |
|
[64] |
|
[65] |
|
[66] |
|
[67] |
|
[68] |
|
[69] |
|
[70] |
|
[71] |
|
[72] |
|
[73] |
|
[74] |
|
[75] |
|
[76] |
|
[77] |
|
[78] |
|
[79] |
|
[80] |
|
[81] |
|
[82] |
|
[83] |
|
[84] |
|
[85] |
|
[86] |
|
[87] |
|
[88] |
|
[89] |
|
[90] |
|
[91] |
|
[92] |
|
[93] |
|
[94] |
|
[95] |
|
[96] |
|
[97] |
|
[98] |
|
[99] |
|
[100] |
|
[101] |
|
[102] |
|
[103] |
|
[104] |
|
[105] |
|
[106] |
|
[107] |
|
[108] |
|
[109] |
|
[110] |
|
[111] |
|
[112] |
|
[113] |
|
[114] |
|
[115] |
|
[116] |
|
[117] |
|
[118] |
|
[119] |
|
[120] |
|
[121] |
|
[122] |
|
[123] |
|
[124] |
|
[125] |
|
[126] |
|
[127] |
|
[128] |
|
[129] |
|
[130] |
|
[131] |
|
[132] |
|
[133] |
|
[134] |
|
[135] |
|
[136] |
|
[137] |
|
[138] |
|
[139] |
|
[140] |
|
[141] |
|
[142] |
|
[143] |
|
[144] |
|
[145] |
|
[146] |
|
[147] |
|
[148] |
|
[149] |
|
[150] |
|
[151] |
|
[152] |
|
[153] |
|
[154] |
|
[155] |
|
[156] |
|
[157] |
|
[158] |
|
[159] |
|
[160] |
|
[161] |
|
[162] |
|
[163] |
|
[164] |
|
[165] |
|
[166] |
|
[167] |
|
[168] |
|
[169] |
|
[170] |
|
[171] |
|
[172] |
|
[173] |
|
[174] |
|
[175] |
|
[176] |
|
[177] |
|
[178] |
|
[179] |
|
[180] |
|
[181] |
|
[182] |
|
[183] |
|
[184] |
|
[185] |
|
[186] |
|
[187] |
|
[188] |
|
[189] |
|
[190] |
|
[191] |
|
[192] |
|
[193] |
|
[194] |
|
[195] |
|
[196] |
|
[197] |
|
[198] |
|
[199] |
|
[200] |
|
[201] |
|
[202] |
|
[203] |
|
[204] |
|
[205] |
|
[206] |
|
[207] |
|
[208] |
|
[209] |
|
[210] |
|
[211] |
|
[212] |
|
[213] |
|
[214] |
|
[215] |
|
[216] |
|
[217] |
|
[218] |
|
[219] |
|
[220] |
|
[221] |
|
[222] |
|
[223] |
|
[224] |
|
[225] |
|
[226] |
|
[227] |
|
[228] |
|
[229] |
|
[230] |
|
[231] |
|
[232] |
|
[233] |
|
[234] |
|
[235] |
|
[236] |
|
[237] |
|
[238] |
|
[239] |
|
[240] |
|
[241] |
|
[242] |
|
[243] |
|
[244] |
|
[245] |
|
[246] |
|
[247] |
|
[248] |
|
[249] |
|
[250] |
|
[251] |
|
[252] |
|
[253] |
|
[254] |
|
[255] |
|
[256] |
|
[257] |
|
[258] |
|
[259] |
|
[260] |
|
[261] |
|
[262] |
|
[263] |
|
[264] |
|
[265] |
|
[266] |
|
[267] |
|
[268] |
|
[269] |
|
[270] |
|
[271] |
|
[272] |
|
[273] |
|
[274] |
|
[275] |
|
[276] |
|
[277] |
|
[278] |
|
[279] |
|
[280] |
|
[281] |
|
[282] |
|
[283] |
|
[284] |
|
[285] |
|
[286] |
|
[287] |
|
[288] |
|
[289] |
|
[290] |
|
[291] |
|
[292] |
|
[293] |
|
[294] |
|
[295] |
|
[296] |
|
[297] |
|
[298] |
|
[299] |
|
[300] |
|
[301] |
|
[302] |
|
[303] |
3D bioprinted models for predicting chemotherapy response in colorectal cancer with/without liver metastases [Internet]. Maryland, MD: National Institutes of Health (NIH); 2021 Feb 16 [cited 2024 Apr 28]. Available from: https://classic.clinicaltrials.gov/ct2/show/NCT04755907.
|
[304] |
|
[305] |
|
[306] |
|
[307] |
|
/
〈 |
|
〉 |