CGMP Consortium: A Multicenter, Longitudinal Clinical Trial Plan for Constipation Multi-Omics and Precision Micro-Ecological Intervention Strategies

Linlin Wang; Tong Zhang; Hongliang Tian; Qiyi Chen; Lianmin Chen; Yuzheng Xue; Gaojue Wu; Yurong Tang; Ning Li; Qixiao Zhai; Wei Chen

doi:10.1016/j.eng.2024.11.011

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Engineering ›› 2024, Vol. 43 ›› Issue (12) : 17-21. DOI: 10.1016/j.eng.2024.11.011

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CGMP Consortium: A Multicenter, Longitudinal Clinical Trial Plan for Constipation Multi-Omics and Precision Micro-Ecological Intervention Strategies

Linlin Wang^a^,^b^,^# ,
Tong Zhang^a^,^b^,^# ,
Hongliang Tian^c ,
Qiyi Chen^c ,
Lianmin Chen^d ,
Yuzheng Xue^e ,
Gaojue Wu^f ,
Yurong Tang^g ,
Ning Li^c ,
Qixiao Zhai^a^,^b ,
Wei Chen^a^,^b^,^h

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Abstract

Highlights

• Prospective multi-omics, multicenter, longitudinal clinical trial protocol CGMP top-level design.

• The CGMP cohort will serve as a unique resource for studying the etiology of constipation and diagnosing constipation based on gut microbiota.

• The CGMP cohort study will help develop microbiota-targeted dietary or clinical therapies for various types of constipation.

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Linlin Wang, Tong Zhang, Hongliang Tian, Qiyi Chen, Lianmin Chen, Yuzheng Xue, Gaojue Wu, Yurong Tang, Ning Li, Qixiao Zhai, Wei Chen. CGMP Consortium: A Multicenter, Longitudinal Clinical Trial Plan for Constipation Multi-Omics and Precision Micro-Ecological Intervention Strategies. Engineering, 2024, 43(12): 17‒21 https://doi.org/10.1016/j.eng.2024.11.011

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