The Tiny but Marvelous Methyl Group in Insecticide Discovery: A Perspective

Qiu Liu; Xingjie Zhang; Tangbing Yang; Yuqin Luo; Runjiang Song; Baoan Song

doi:10.1016/j.eng.2025.11.028

Engineering ›› :202511028 DOI: 10.1016/j.eng.2025.11.028

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The Tiny but Marvelous Methyl Group in Insecticide Discovery: A Perspective

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Abstract

As the most fundamental organic unit, the methyl group is ubiquitously present yet frequently overlooked in various insecticide architectures. Despite its simplicity, this moiety plays a pivotal role in insecticide discovery. This perspective highlights documented cases of popular insecticides in which methyl substitution increases target affinity and bioactivity, alongside an analysis of the underlying molecular mechanisms. We propose insights into currently unsolved issues and future directions for leveraging methyl incorporation to accelerate the discovery of new agrochemicals. To our knowledge, this constitutes the first comprehensive perspective on the functional significance of methyl groups in agricultural chemistry. We expect this work to inspire methyl-driven optimization strategies for next-generation insecticides, thereby contributing to sustainable pest management.

Keywords

Agrochemical / Insecticide / Mode of action / Magic methyl / Structure-activity relationship

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Qiu Liu, Xingjie Zhang, Tangbing Yang, Yuqin Luo, Runjiang Song, Baoan Song. The Tiny but Marvelous Methyl Group in Insecticide Discovery: A Perspective. Engineering 202511028 DOI:10.1016/j.eng.2025.11.028

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