Natural Diverse Components, Herbgenomics, and Artificial Intelligence: A Multi-Dimensional Paradigm for Polyherbal Formulation Research

Liang Leng , Jing Mo , Hongguo Chen , Shenjie You , Can Wang , Jun Lu , Zhaotong Cong , Wei Chen , Chi Song , Sanyin Zhang

Engineering ›› : 202601021

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Engineering ›› :202601021 DOI: 10.1016/j.eng.2026.01.021
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Natural Diverse Components, Herbgenomics, and Artificial Intelligence: A Multi-Dimensional Paradigm for Polyherbal Formulation Research
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Liang Leng, Jing Mo, Hongguo Chen, Shenjie You, Can Wang, Jun Lu, Zhaotong Cong, Wei Chen, Chi Song, Sanyin Zhang. Natural Diverse Components, Herbgenomics, and Artificial Intelligence: A Multi-Dimensional Paradigm for Polyherbal Formulation Research. Engineering 202601021 DOI:10.1016/j.eng.2026.01.021

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References

[1]

Chen H, Liu Z, Du Y, Meng X, Xue L, Sun X, et al. Comparative analysis of Chinese classical prescriptions and global traditional polyherbal formulations: insights from the database of global polyherbal formulation (GPFD). Chin Med 2025; 20(1):169.

[2]

Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: concept of ayurveda. Pharmacogn Rev 2014; 8(16):73-80.

[3]

Broekaert WF, Cammue BPA, Bolle MFCD, Thevissen K, Samblanx GWD, Osborn RW, et al. Antimicrobial peptides from plants. Crit Rev Plant Sci 1997; 16(3):297-323.

[4]

Dar RA, Shahnawaz M, Ahanger MA, Majid I. Exploring the diverse bioactive compounds from medicinal plants: a review. J Phytopharm 2023; 12(3):189-95.

[5]

Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT. the International Natural Product Sciences Taskforce. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov 2021; 20(3):200-16.

[6]

Wink M. Modes of action of herbal medicines and plant secondary metabolites. Medicines 2015; 2(3):251-86.

[7]

Wicks C, Hudlicky T, Rinner U. Morphine alkaloids: history, biology, and synthesis. Alkaloids Chem Biol 2021; 86:145-342.

[8]

Bandyopadhyay S. An 8,000-year history of use and abuse of opium and opioids: how that matters for a successful control of the epidemic? (P4.9-055). Neurology 2019; 92(15_supplement). P4.9-055.

[9]

Ng SV. Opium use in 19th-century Britain: the roots of moralism in shaping drug legislation. AJP residents’. Am J Psychiatry Resid J 2016; 11(6):14.

[10]

Harvey AL, Edrada-Ebel R, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov 2015; 14(2):111-29.

[11]

Cragg GM, Schepartz SA, Suffness M, Grever MR. The Taxol supply crisis. new NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. J Nat Prod 1993; 56(10):1657-68.

[12]

Lacchini E, Goossens A. Combinatorial control of plant specialized metabolism: mechanisms, functions, and consequences. Annu Rev Cell Dev Biol 2020; 36(1):291-313.

[13]

Hu H, Shen X, Liao B, Luo L, Xu J, Chen S. Herbgenomics: a stepping stone for research into herbal medicine. Sci China Life Sci 2019; 62(7):913-20.

[14]

Chae L, Kim T, Nilo-Poyanco R, Rhee SY. Genomic signatures of specialized metabolism in plants. Science 2014; 344(6183):510-3.

[15]

Sun W, Xu Z, Song C, Chen S. Herbgenomics: decipher molecular genetics of medicinal plants. Innovation 2022; 3(6):100322.

[16]

Pei Y, Leng L, Sun W, Liu B, Feng X, Li X, et al. Whole-genome sequencing in medicinal plants: current progress and prospect. Sci China Life Sci 2024; 67(2):258-73.

[17]

Lin L, Xu YJ, He DP, Han Y, Tang GH, Yang ZM, et al. A retrospective study on clinical features of and treatment methods for 77 severe cases of SARS. Am J Chin Med 2003; 31(6):821-39.

[18]

Yeh MH, Chiu HP, Wu MC, Koo M, Lin NW, Liao KK, et al. Integrated Chinese herbal medicine and western medicine on the survival in patients with colorectal cancer: a retrospective study of medical records. Evid Based Complement Alternat Med 2020; 2020(1):4561040.

[19]

Zhao M, Chen Y, Wang C, Xiao W, Chen S, Zhang S, et al. Systems pharmacology dissection of multi-scale mechanisms of action of Huo-Xiang-Zheng-Qi formula for the treatment of gastrointestinal diseases. Front Pharmacol 2019; 9:1448.

[20]

Wishart DS, Guo A, Oler E, Wang F, Anjum A, Peters H, et al. HMDB 5.0: the human metabolome database for 2022. Nucleic Acids Res 2022; 50(D1):D622-31.

[21]

Chen W, Yu Z, Leng L, Sun D, Liu H, Gong RZ, et al. Artificial intelligence-curated repository of gene-encoded natural diverse components from herbal medicines. Innovation 2025; 6(12):101011.

[22]

Chen W, Liu X, Zhang S, Chen S. Artificial intelligence for drug discovery: resources, methods, and applications. MolTher Nucleic Acids 2023; 31:691-702.

[23]

Song Z, Chen G, Chen CYC. AI empowering traditional Chinese medicine? Chem Sci 2024; 15(41):16844-86.

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