The Present and Future of Aging-on-A-Chip

Xuan Mei; Xingchen Liu; Zaiyi Yang; Nigel Foo; Peter Wang; Ming Shao; Dean Ho; Yu Shrike Zhang

doi:10.1016/j.eng.2026.03.005

Engineering ›› :202603005 DOI: 10.1016/j.eng.2026.03.005

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The Present and Future of Aging-on-A-Chip

Xuan Mei ^a^,^#
, Xingchen Liu ^a^,^#
, Zaiyi Yang ^a
, Nigel Foo ^b^,^c^,^d
, Peter Wang ^b^,^c^,^d
, Ming Shao ^e
, Dean Ho ^b^,^c^,^d^,^f^,^g^,^*
, Yu Shrike Zhang ^a^,^h^,ⁱ^,^*

Author information +

^a Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA

^b Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117583 Singapore

^c Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456 Singapore

^d The N.1 Institute for Health (N.1), National University of Singapore, Singapore 117456 Singapore

^e Miner School of Computer and Information Sciences, University of Massachusetts Lowell, MA 01854, USA

^f Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600 Singapore

^g The Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), National University of Singapore, Singapore 117456 Singapore

^h Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA

ⁱ Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Corresponding author:

^* biedh@nus.edu.sg (Dean Ho),

yszhang@bwh.harvard.edu (Yu Shrike Zhang)

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Xuan Mei, Xingchen Liu, Zaiyi Yang, Nigel Foo, Peter Wang, Ming Shao, Dean Ho, Yu Shrike Zhang. The Present and Future of Aging-on-A-Chip. Engineering 202603005 DOI:10.1016/j.eng.2026.03.005

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