Multifunctional Bone Cements in Regenerative Medicine

Sruthi Suresh; Mary Susan J. Anthraper; Arthi Chandramouli; Joel D. Bumgardner; Nathaniel S. Hwang; Jayakumar Rangasamy

doi:10.1016/j.eng.2026.09.001

Engineering ›› :202609001 DOI: 10.1016/j.eng.2026.09.001

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Multifunctional Bone Cements in Regenerative Medicine

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Abstract

Multifunctional bone cements have been broadly applied in regenerative medicine as mechanical reinforcement for bone defects because their bioactive characteristics considerably promote tissue regeneration. In addition to their traditional application as space-filling materials, multifunctional bone cements can be used to overcome challenges, such as poor bioactivity, uncontrolled degradation, and mechanical integrity. They actively guide tissue repair by mediating cell recruitment, vascular ingrowth, and matrix mineralization. Additionally, they have osteogenic, angiogenic, antibacterial, and immunomodulatory properties that are valuable for bone regeneration. Therapeutic ions, polymers, ceramics, nanoparticles, and other bioactive agents, such as anti-

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Multifunctional / Bone cements / Regenerative medicine / Tissue engineering / Osteogenic / Bone tissue engineering

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Sruthi Suresh, Mary Susan J. Anthraper, Arthi Chandramouli, Joel D. Bumgardner, Nathaniel S. Hwang, Jayakumar Rangasamy. Multifunctional Bone Cements in Regenerative Medicine. Engineering 202609001 DOI:10.1016/j.eng.2026.09.001

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