Nanomaterial-Mediated Clearance of Circulating Cell-Free DNA Reduces Periodontitis-Associated Arterial Thrombosis

Xuanzhi Zhu; Jinting Ge; Chengxin Weng; Quanxin Ning; Yuhan Qi; Suwan Ding; Huiyi Liang; Biao Jing; Xiao Chen; Shouzheng Cheng; Jichun Zhao; Ding Yuan; Tiehao Wang; Huawei Zhang; Fangman Chen; Bing Shi; Lei Zhao; Xianglong Han; Yafei Wu; Dan Shao; Kam W. Leong; Hanyao Huang

doi:10.1016/j.eng.2026.09.005

Engineering ›› :202609005 DOI: 10.1016/j.eng.2026.09.005

research-article

Nanomaterial-Mediated Clearance of Circulating Cell-Free DNA Reduces Periodontitis-Associated Arterial Thrombosis

Xuanzhi Zhu ^a^,^b^,^#
, Jinting Ge ^c^,^#
, Chengxin Weng ^c^,^#
, Quanxin Ning ^d^,^#
, Yuhan Qi ^c
, Suwan Ding ^e
, Huiyi Liang ^e
, Biao Jing ^c
, Xiao Chen ^a^,^b
, Shouzheng Cheng ^a^,^b
, Jichun Zhao ^c
, Ding Yuan ^c
, Tiehao Wang ^c
, Huawei Zhang ^g
, Fangman Chen ^a^,^d
, Bing Shi ^a^,^f
, Lei Zhao ^a^,^b
, Xianglong Han ^a^,^h
, Yafei Wu ^a^,^b^,^*
, Dan Shao ^a^,^d^,^*
, Kam W. Leong ^e^,ⁱ^,^*
, Hanyao Huang ^a^,^e^,^f^,^*

Author information +

^a State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu 610041, China

^b Department of Periodontics, West China Hospital of Stomatology, Sichuan University , Chengdu 610041, China

^c Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University , Chengdu 610041, China

^d National Engineering Research Center for Tissue Restoration and Reconstruction & School of Medicine, South China University of Technology , Guangzhou 510006, China

^e Department of Biomedical Engineering, Columbia University , New York, NY 10027, USA

^f Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University , Chengdu 610041, China

^g Department of Radiology, West China Hospital, Sichuan University , Chengdu 610041, China

^h Department of Orthodontics, West China Hospital of Stomatology, Sichuan University , Chengdu 610041, China

ⁱ Department of Systems Biology, Columbia University Medical Center , New York, NY 10032, USA

^*E-mail addresses: yfw1110@163.com (Y. Wu),

stanauagate@outlook.com (D. Shao),

kam.leong@columbia.edu (K.W. Leong),

huanghanyao_cn@scu.edu.cn (H. Huang).

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Periodontitis

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Xuanzhi Zhu, Jinting Ge, Chengxin Weng, Quanxin Ning, Yuhan Qi, Suwan Ding, Huiyi Liang, Biao Jing, Xiao Chen, Shouzheng Cheng, Jichun Zhao, Ding Yuan, Tiehao Wang, Huawei Zhang, Fangman Chen, Bing Shi, Lei Zhao, Xianglong Han, Yafei Wu, Dan Shao, Kam W. Leong, Hanyao Huang. Nanomaterial-Mediated Clearance of Circulating Cell-Free DNA Reduces Periodontitis-Associated Arterial Thrombosis. Engineering 202609005 DOI:10.1016/j.eng.2026.09.005

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